JL Vincent DJ Bihari PM Suter HA Bruining J White MH Nicolas-Chanoin M Wolff RC Spencer M Hemmer 1995 The prevalence of nosocomial infection in intensive care units in Europe. Results of the European Prevalence of Infection in Intensive Care (EPIC) Study. EPIC International Advisory Committee JAMA 274 639 644 7637145 10.1001/jama.274.8.639 1:STN:280:DyaK2MzmsVWnuw%3D%3D
P Jiménez A Torres R Rodríguez-Roisin JP de la Bellacasa R Aznar JM Gatell A Agustí-Vidal 1990 Incidence, risk and prognosis factors of nosocomial pneumonia in mechanically ventilated patients Am Rev Resp Dis 142 523 528 2202245
JY Fagon J Chastre A Vuagnat JL Trouillet A Novara C Gibert 1996 Nosocomial pneumonia and mortality among patients in intensive care unit JAMA 275 866 869 8596225 10.1001/jama.275.11.866 1:STN:280:DyaK287ntlygsg%3D%3D (Pubitemid 26087224)
MH Kollef P Silver DM Murphy E Trovillion 1995 The effect of late-onset ventilator associated pneumonia in determining patient mortality Chest 108 1655 1662 7497777 10.1378/chest.108.6.1655 1:STN:280:DyaK28%2FpvVSisQ%3D%3D
JY Fagon J Chastre AJ Hance P Montravers A Novara C Gibert 1993 Nosocomial pneumonia in ventilated patients: a cohort study evaluating attributable mortality and hospital stay Am J Med 94 281 288 8452152 10.1016/0002-9343(93)90060-3 1:STN:280:DyaK3s7pvVyruw%3D%3D (Pubitemid 23074802)
MH Kollef KR Bock RD Richards ML Hearns 1995 The safety and diagnostic accuracy of minibronchoalveolar lavage in patients with suspected ventilator-associated pneumonia Ann Intern Med 122 743 748 7717596 1:STN:280:DyaK2M3jtlKnsQ%3D%3D
P Damas D Ledoux M Nys M Monchi P Wiesen B Beauve JC Preiser 2008 Intensive care unit acquired infection and organ failure Intensive Care Med 34 856 864 18259728 10.1007/s00134-008-1018-7 (Pubitemid 351571194)
JR Le Gall S Lemeshow F Saulnier 1993 A new simplified acute physiology score (SAPS II) based on a European/North American multicenter study JAMA 270 2957 2963 8254858 10.1001/jama.270.24.2957 1:STN:280:DyaK2c%2Fns1GmtA%3D%3D (Pubitemid 24000804)
WR McCabe GG Jackson 1962 Gram-negative bacteremia, aetiology and ecology Arch Intern Med 110 845 853
J Chastre M Wolff JY Fagon S Chevret F Thomas D Wermert E Clementi J Gonzalez D Jusserand P Asfar D Perrin F Fieux S Aubas PneumA Trial Group 2003 Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial JAMA 290 2588 2598 14625336 10.1001/jama.290.19.2588 1:CAS:528:DC%2BD3sXpt1Cmu7g%3D (Pubitemid 37443289)
American College of Chest Physicians/Society of Critical Care Medicine 1992 American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis Crit Care Med 20 864 874 10.1097/00003246-199206000-00025
JL Vincent R Moreno J Takala S Willatts A De Mendonça H Bruining CK Reinhart PM Suter LG Thijs 1996 The SOFA (sepsis-related organ failure assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine Intensive Care Med 22 707 710 8844239 10.1007/BF01709751 1:STN:280:DyaK2s%2FgtFantQ%3D%3D
R Moreno JL Vincent R Matos A Mendonça F Cantraine L Thijs J Takala C Sprung M Antonelli H Bruining S Willatts 1999 The use of maximum SOFA score to quantify organ dysfunction/failure in intensive care. Results of a prospective, multicentre study. Working Group on Sepsis Related Problems of the ESICM Intensive Care Med 25 686 696 10470572 10.1007/s001340050931 1:STN:280:DyaK1MzpvFGqsQ%3D%3D (Pubitemid 29376122)
C Alberti C Brun-Buisson SV Goodman D Guidici J Granton R Moreno M Smithies O Thomas A Artigas JR Le Gall European Sepsis Group 2003 Influence of systemic inflammatory response syndrome and sepsis outcome of critically ill infected patients Am J Respir Crit Care Med 168 77 84 12702548 10.1164/rccm.200208-785OC (Pubitemid 37046636)
DF Brown J Andrews A King AP MacGowan 2000 Detection of extended-spectrum beta-lactamases with Etest and double disc potentialisation methods J Antimicrob Chemother 46 327 328 10933666 10.1093/jac/46.2.327 1:CAS:528:DC%2BD3cXmtFCisLg%3D (Pubitemid 30639312)
American Thoracic Society; Infectious Diseases Society of America 2005 Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia Am J Respir Crit Care Med 171 388 416 10.1164/rccm.200405-644ST (Pubitemid 40227463)
J Chastre JY Fagon 2002 Ventilator-associated pneumonia Am J Respir Crit Care Med 165 867 903 11934711 (Pubitemid 34774654)
JL Vincent Y Sakr CL Sprung VM Ranieri K Reinhart H Gerlach R Moreno J Carlet JR Le Gall D Payen Sepsis Occurrence in Acutely Ill Patients Investigators 2006 Sepsis in European intensive units: results of the SOAP study Crit Care Med 34 344 353 16424713 10.1097/01.CCM.0000194725.48928.3A (Pubitemid 43145611)
T Lisboa E Diaz M Sa-Borges A Socias J Sole-Violan A Rodríguez J Rello 2008 VAP-PIRO: a tool for predicting ICU mortality and health care resources use in ventilator-associated pneumonia Chest 134 1208 1216 18779186 10.1378/chest.08-1106
M Nguile-Makao JR Zahar A Français A Tabah M Garrouste-Orgeas B Allaouchiche D Goldgran-Toledano E Azoulay C Adrie S Jamali C Clec'h B Souweine JF Timsit 2010 Attributable mortality of ventilator-associated pneumonia: respective impact of main characteristics at ICU admission and VAP onset using conditional logistic regression and multi-state models Intensive Care Med 36 781 789 20232046 10.1007/s00134-010-1824-6
M Klompas 2009 The paradox of ventilator-associated pneumonia prevention measures Crit Care 13 315 19849825 10.1186/cc8036
I Clinel SM Opal 2009 Molecular biology of inflammation and sepsis: a primer Crit Care Med 37 291 304 10.1097/CCM.0b013e31819267fb
J Carlet J Cohen T Calandra SM Opal H Masur 2008 Sepsis: time to reconsider the concept Crit Care Med 36 964 966 18431286 10.1097/CCM. 0B013E318165B886
WG Melsen MM Rovers MJM Bonten 2009 Ventilator associated pneumonia and mortality: a systematic review of observational studies Crit Care Med 37 2709 2710 19885994 10.1097/CCM.0b013e3181ab8655
O Leroy A Meybeck T d'Escrivan P Devos E Kipnis H Georges 2003 Impact of adequacy of initial antimicrobial therapy on the prognosis of patients with ventilator-associated pneumonia Intensive Care Med 29 2170 2173 13680112 10.1007/s00134-003-1990-x (Pubitemid 38030667)
C Alberti C Brun-Buisson H Burchardi C Martin S Goodman A Artigas A Sicignano M Palazzo R Moreno R Boulmé E Lepage R Le Gall 2002 Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort study Intensive Care Med 28 108 121 11907653 10.1007/s00134-001-1143-z (Pubitemid 34293822)
C Brun-Buisson P Meshaka P Pinton B Vallet EPISEPSIS Study Group 2004 EPISEPSIS: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units Intensive Care Med 30 580 588 14997295 10.1007/s00134-003-2121-4 1:STN:280:DC%2BD2c3jtVegtg%3D%3D (Pubitemid 38530092)
T Lisboa J Rello 2008 Diagnosis of ventilator-associated pneumonia: Is there a gold standard and a simple approach? Curr Opin Infect Dis 21 174 178 18317042 10.1097/QCO.0b013e3282f55dd1 (Pubitemid 351641522)
M Niederman 2010 The argument against using quantitative cultures in clinical trials and for the management of ventilator-associated pneumonia Clin Infect Dis 51 593 599
The Canadian Critical Care Trials Group 2006 A randomized trial of diagnostic techniques for ventilator-associated pneumonia N Engl J Med 355 2619 2630 10.1056/NEJMoa052904 (Pubitemid 44969121)
P Eggimann S Hugonnet H Sax S Touveneau JC Chevrolet D Pittet 2003 Ventilator-associated pneumonia: caveats for benchmarking Intensive Care Med 29 2086 2089 12955177 10.1007/s00134-003-1991-9 (Pubitemid 37487146)
Lacherade JC, De Jonghe B, Guezennec P, Debbat K, Hayon J, Monsel A, Fangio P, Appere de Vecchi C, Ramaut C, Outin H, Bastuji-Garin S (2010) Intermittent subglottic secretion drainage and ventilator-associated pneumonia : a multicenter trial. Am J Resp Crit Care Med. 182:910-917. doi: 10.1164/rccm.200906-0838OC
M Magret R Amaya-Villar J Garnacho T Lisboa E Díaz J Dewaele M Deja E Manno J Rello EU-VAP/CAP Study Group 2010 Ventilator associated pneumonia in trauma patients is associated with lower mortality. Results from EU-VAP study J Trauma 69 849 854 20938271 10.1097/TA.0b013e3181e4d7be 1:STN:280:DC%2BC3cfpvFyjsg%3D%3D
