Enhanced nutritionally induced adipose tissue development in mice with stromelysin-1 gene inactivation.

[en] To investigate a potential role of stromelysin-1 (MMP-3) in development of adipose tissue, 5 week old male MMP-3 deficient mice (MMP-3(-/-)) and wild-type (MMP-3(+/+)) controls were kept on a high fat diet (HFD) for 15 weeks. MMP-3(-/-) mice were hyperphagic and gained more weight than the MMP-3(+/+) mice. At the time of sacrifice, the body weight of the MMP-3(-/-) mice was significantly higher than that of the MMP-3(+/+) mice, as was the weight of the isolated subcutaneous (SC) and gonadal (GON) fat deposits. Significant adipocyte hypertrophy was observed in the GON but not in the SC adipose tissue of MMP-3(-/-) mice. Fasting plasma glucose and cholesterol levels were comparable in both genotypes, whereas triglyceride levels were significantly lower in MMP-3(-/-) mice. Staining with an endothelial cell specific lectin revealed a significantly higher blood vessel density and larger total stained area in the GON adipose tissues of MMP-3(-/-) mice. Thus, in a murine model of nutritionally induced obesity, MMP-3 impairs adipose tissue development, possibly by affecting food intake and/or adipose tissue-related angiogenesis.

Disciplines :

Endocrinology, metabolism & nutrition

Author, co-author :

Maquoi, Erik ; Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement

Demeulemeester, Diego

Vörös, Gabor

Collen, Désiré

Lijnen, Roger

Language :

English

Title :

Enhanced nutritionally induced adipose tissue development in mice with stromelysin-1 gene inactivation.

Publication date :

April 2003

Journal title :

Thrombosis and Haemostasis

ISSN :

0340-6245

eISSN :

2567-689X

Publisher :

Schattauer Gmbh-Verlag Medizin Naturwissenschaften, Stuttgart, Germany

Volume :

Issue :

Pages :

696-704

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 10 November 2011

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