Fine-mapping and construction of a bovine contig spanning the ovine callipyge locus.

Shay, T. L.; Berghmans, S.; SEGERS, Karin; Meyers, S.; Beever, J. E.; Womack, J. E.; Cockett, N. E.; Georges, Michel; Charlier, Carole

doi:10.1007/s003350010248

Reference : Fine-mapping and construction of a bovine contig spanning the ovine callipyge locus.


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Genetics & genetic processes
	To cite this reference:	http://hdl.handle.net/2268/102190

Title :	Fine-mapping and construction of a bovine contig spanning the ovine callipyge locus.
Language :	English
Author, co-author :	Shay, T. L. [> > > >]
	Berghmans, S. [> > > >]
	SEGERS, Karin [Centre Hospitalier Universitaire de Liège - CHU > > Génétique]
	Meyers, S. [> > > >]
	Beever, J. E. [> > > >]
	Womack, J. E. [> > > >]
	Cockett, N. E. [ > > ]
	Georges, Michel [Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale >]
	Charlier, Carole [Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale >]
Publication date :	2001
Journal title :	Mammalian Genome
Publisher :	Springer Verlag
Volume :	12
Issue/season :	2
Pages :	141-9
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0938-8990
e-ISSN :	1432-1777
City :	New York
Country :	NY
Keywords :	[en] Animals ; Cattle ; Cloning, Molecular ; Contig Mapping ; Cricetinae ; Crosses, Genetic ; Genotype ; Male ; Microsatellite Repeats/genetics ; Muscle Development ; Muscle Fibers, Fast-Twitch/metabolism ; Muscle, Skeletal/growth & development/metabolism ; Proteins/genetics ; Radiation Hybrid Mapping ; Sheep
Abstract :	[en] The callipyge (CLPG) gene was fine-mapped by linkage analysis to a 4.6-cM chromosome interval on distal ovine OAR18q, flanked by microsatellite markers IDVGA30 and OY3. The OAR18q linkage map and human HSA14q transcript map were aligned by genotyping two bovine-hamster whole-genome radiation hybrid panels with the microsatellite markers, as well as with sequences corresponding to HSA 14q genes. Using Type I loci mapping to the IDVGA30-OY3 interval as anchor points, we have constructed a 1.4-Mb bovine BAC contig containing the IDVGA30-OY3 interval. We demonstrate that the IDVGA30-OY3 interval spans approximately 770 kb and contains at least four genes: YY1, WARS, DLK1, and GTL2.
Permalink :	http://hdl.handle.net/2268/102190
DOI :	10.1007/s003350010248

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