Article (Scientific journals)
Mapping QTL influencing gastrointestinal nematode burden in Dutch Holstein-Friesian dairy cattle.
Coppieters, Wouter; Mes, Ted H M; Druet, Tom et al.
2009In BMC Genomics, 10, p. 96
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Keywords :
Animals; Cattle/genetics/parasitology; Cattle Diseases/genetics/parasitology; Chromosome Mapping/veterinary; Dairying; Feces/parasitology; Female; Genome; Genotype; Intestinal Diseases, Parasitic/genetics/parasitology; Linkage Disequilibrium; Male; Nematoda/physiology; Nematode Infections/genetics/parasitology; Ovum/parasitology; Polymorphism, Single Nucleotide; Quantitative Trait Loci
Abstract :
[en] BACKGROUND: Parasitic gastroenteritis caused by nematodes is only second to mastitis in terms of health costs to dairy farmers in developed countries. Sustainable control strategies complementing anthelmintics are desired, including selective breeding for enhanced resistance. RESULTS AND CONCLUSION: To quantify and characterize the genetic contribution to variation in resistance to gastro-intestinal parasites, we measured the heritability of faecal egg and larval counts in the Dutch Holstein-Friesian dairy cattle population. The heritability of faecal egg counts ranged from 7 to 21% and was generally higher than for larval counts. We performed a whole genome scan in 12 paternal half-daughter groups for a total of 768 cows, corresponding to the approximately 10% most and least infected daughters within each family (selective genotyping). Two genome-wide significant QTL were identified in an across-family analysis, respectively on chromosomes 9 and 19, coinciding with previous findings in orthologous chromosomal regions in sheep. We identified six more suggestive QTL by within-family analysis. An additional 73 informative SNPs were genotyped on chromosome 19 and the ensuing high density map used in a variance component approach to simultaneously exploit linkage and linkage disequilibrium in an initial inconclusive attempt to refine the QTL map position.
Disciplines :
Agriculture & agronomy
Animal production & animal husbandry
Veterinary medicine & animal health
Genetics & genetic processes
Author, co-author :
Coppieters, Wouter ;  Université de Liège - ULiège > Département de productions animales > Département de productions animales
Mes, Ted H M
Druet, Tom ;  Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Farnir, Frédéric  ;  Université de Liège - ULiège > Département de productions animales > Biostatistiques et bioinformatique appliquées aux sc. vétér.
Tamma, Nico ;  Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Schrooten, Chris
Cornelissen, Albert W C A
Georges, Michel  ;  Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Ploeger, Harm W
Language :
English
Title :
Mapping QTL influencing gastrointestinal nematode burden in Dutch Holstein-Friesian dairy cattle.
Publication date :
2009
Journal title :
BMC Genomics
eISSN :
1471-2164
Publisher :
BioMed Central
Volume :
10
Pages :
96
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 07 May 2010

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