Article (Scientific journals)
Interplay between spontaneous and induced brain activity during human non-rapid eye movement sleep.
Dang Vu, Thien Thanh; Bonjean, Maxime; Schabus, Manuel et al.
2011In Proceedings of the National Academy of Sciences of the United States of America, 108 (37), p. 15438-43
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Keywords :
Adolescent; Adult; Audiometry, Pure-Tone; Brain Mapping; Electroencephalography; Female; Humans; Male; Sleep, REM/physiology; Wakefulness/physiology; Young Adult
Abstract :
[en] Humans are less responsive to the surrounding environment during sleep. However, the extent to which the human brain responds to external stimuli during sleep is uncertain. We used simultaneous EEG and functional MRI to characterize brain responses to tones during wakefulness and non-rapid eye movement (NREM) sleep. Sounds during wakefulness elicited responses in the thalamus and primary auditory cortex. These responses persisted in NREM sleep, except throughout spindles, during which they became less consistent. When sounds induced a K complex, activity in the auditory cortex was enhanced and responses in distant frontal areas were elicited, similar to the stereotypical pattern associated with slow oscillations. These data show that sound processing during NREM sleep is constrained by fundamental brain oscillatory modes (slow oscillations and spindles), which result in a complex interplay between spontaneous and induced brain activity. The distortion of sensory information at the thalamic level, especially during spindles, functionally isolates the cortex from the environment and might provide unique conditions favorable for off-line memory processing.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Neurology
Author, co-author :
Dang Vu, Thien Thanh ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie
Bonjean, Maxime
Schabus, Manuel
Boly, Mélanie ;  Université de Liège - ULiège > Centre de Recherches du Cyclotron - Comascience group > Neurologie
Darsaud, Annabelle
Desseilles, Martin ;  Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie et psychologie médicale
Degueldre, Christian ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Balteau, Evelyne ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Phillips, Christophe  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Luxen, André ;  Université de Liège - ULiège > Département de chimie (sciences) > Chimie organique de synthèse
Sejnowski, Terrence J
Maquet, Pierre  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Language :
English
Title :
Interplay between spontaneous and induced brain activity during human non-rapid eye movement sleep.
Publication date :
2011
Journal title :
Proceedings of the National Academy of Sciences of the United States of America
ISSN :
0027-8424
eISSN :
1091-6490
Publisher :
National Academy of Sciences, Washington, United States - District of Columbia
Volume :
108
Issue :
37
Pages :
15438-43
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
FMRE - Fondation Médicale Reine Elisabeth [BE]
Fonds Léon Fredericq [BE]
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