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Profil

Martinez Alvarez Juan Andrés

See author's contact details
ORCID
0000-0002-2331-5369
Main Referenced Co-authors
Delvigne, Frank  (19)
Henrion, Lucas  (9)
Vandenbroucke, Vincent  (9)
Telek, Samuel  (7)
Bouchat, Romain  (6)
Main Referenced Keywords
Biotechnology (3); Recombinant Proteins (3); Recombinant Proteins/metabolism (3); Applied Microbiology and Biotechnology (2); Bioengineering (2);
Main Referenced Disciplines
Biotechnology (12)
Microbiology (6)
Biochemistry, biophysics & molecular biology (4)

Publications (total 21)

The most downloaded
106 downloads
Martinez Alvarez, J. A., Bouchat, R., Gallet de Saint Aurin, T., Martínez, L. M., Caspeta, L., Telek, S., Zicler, A., Gosset, G., & Delvigne, F. (2025). Automated adjustment of metabolic niches enables the control of natural and engineered microbial co-cultures. Trends in Biotechnology. doi:10.1101/2024.05.14.594082 https://hdl.handle.net/2268/318679

The most cited

26 citations (OpenAlex)

Martinez Alvarez, J. A., Delvenne, M., Henrion, L., Moreno, F., Telek, S., Dusny, C., & Delvigne, F. (October 2022). Controlling microbial co-culture based on substrate pulsing can lead to stability through differential fitness advantages. PLoS Computational Biology, 18 (10), 1010674. doi:10.1371/journal.pcbi.1010674 https://hdl.handle.net/2268/316101

Josselin, L., Bouchat, R., Martinez Alvarez, J. A., Howa Lopez, F., Telek, S., Zicler, A., & Delvigne, F. (February 2026). Multi-scale control of microbial systems: from single cells to metacommunities [Poster presentation]. Belgium Society of Microbiology 2026 : The next generation of Microbiology, Bruxelles, Belgium.
Peer reviewed

Martinez Alvarez, J. A., Bouchat, R., Gallet de Saint Aurin, T., Martínez, L. M., Caspeta, L., Telek, S., Zicler, A., Gosset, G., & Delvigne, F. (2025). Automated adjustment of metabolic niches enables the control of natural and engineered microbial co-cultures. Trends in Biotechnology. doi:10.1101/2024.05.14.594082
Peer Reviewed verified by ORBi

Bouchat, R., Martinez Alvarez, J. A., Josselin, L., Howa Lopez, F., & Delvigne, F. (2025). Dynamic Control of Microbial Co-Cultures: Automated Niche Adjustment for Continuous and Fed-Batch Bioprocessing [Poster presentation]. Annual Symposium 2025: amAIzing Microbiology: demystifying AI for all microbiologists, Brussels, Belgium.

Martinez Alvarez, J. A., Bouchat, R., Gallet de Saint Aurin, T., Vandenbroucke, V., & Delvigne, F. (09 May 2024). Elementary Flux Mode Analysis predicts co-culture stability in continuous bioprocesses [Poster presentation]. 8th BioProScale Symposium 2024, Berlin, Germany.
Editorial reviewed

Bouchat, R., Martinez Alvarez, J. A., Gallet de Saint Aurin, T., Vandenbroucke, V., & Delvigne, F. (08 March 2024). Reactive flow cytometry as an enabling technology for continuous co-cultures [Poster presentation]. Annual Symposium 2024: Milestones in Microbiology, Brussels, Belgium.

Tieke, M., Martinez Alvarez, J. A., Henrion, L., & Delvigne, F. (08 March 2024). Assimilation of plastic-derived monomers by P. putida KT2440 in continuous cultures [Poster presentation]. 30th Annual BSM Symposium, Brussel, Belgium.

Henrion, L., Delvigne, F., Martinez Alvarez, J. A., Tieke, M., & Vandenbroucke, V. (08 March 2024). Burdensome gene expression promotes heterogeneity in cellular response that can be mitigated up to a tipping point [Poster presentation]. Belgian society for microbiology, Bruxelles, Belgium.

Henrion, L., Martinez Alvarez, J. A., Vandenbroucke, V., Delvenne, M., Telek, S., Zicler, A., Grünberger, A., & Delvigne, F. (02 October 2023). Fitness cost associated with cell phenotypic switching drives population diversification dynamics and controllability. Nature Communications, 14 (1), 6128. doi:10.1038/s41467-023-41917-z
Peer Reviewed verified by ORBi

Delvigne, F., & Martinez Alvarez, J. A. (October 2023). Advances in automated and reactive flow cytometry for synthetic biotechnology. Current Opinion in Biotechnology, 83, 102974. doi:10.1016/j.copbio.2023.102974
Peer Reviewed verified by ORBi

Tieke, M., Martinez Alvarez, J. A., & Delvigne, F. (19 September 2023). Controlling the phenotypic switching of P. putida population for the assimilation of plastic-derived compounds [Poster presentation]. 6th Microbial Stress 2023 Conference, Vienna, Austria.

Henrion, L., Martinez Alvarez, J. A., Vandenbroucke, V., Delvenne, M., Telek, S., Zicler, A., Grunberger, A., & Delvigne, F. (2023). Fitness cost associated with cell phenotypic switching drives population diversification dynamics and controllability. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/305924. doi:10.1101/2023.04.06.535654

Velastegui, E., Quezada, J., Guerrero, K., Altamirano, C., Martinez Alvarez, J. A., Berrios, J., & Fickers, P. (April 2023). Is heterogeneity in large-scale bioreactors a real problem in recombinant protein synthesis by Pichia pastoris? Applied Microbiology and Biotechnology, 107 (7-8), 2223 - 2233. doi:10.1007/s00253-023-12434-2
Peer Reviewed verified by ORBi

Vandenbroucke, V., Henrion, L., Martinez Alvarez, J. A., & Delvigne, F. (10 February 2023). Managing bacterial growth and phenotypic diversification through the external control of synthetic gene circuits [Poster presentation]. Annual Symposium 2023: Amazing Microbes, Brussels, Belgium.

Delvigne, F., Henrion, L., Vandenbroucke, V., & Martinez Alvarez, J. A. (2023). Avoiding the All-or-None Response in Gene Expression During E. coli Continuous Cultivation Based on the On-Line Monitoring of Cell Phenotypic Switching Dynamics. In Inclusion Bodies Methods and Protocols. Methods in Molecular Biology. doi:10.1007/978-1-0716-2930-7_7
Peer reviewed

Bouchat, R., Martinez Alvarez, J. A., & Delvigne, F. (07 December 2022). Control of microbial consortia in bioreactors [Poster presentation]. Emerging Applications of Microbes (2nd edition), Leuven, Belgium.

Vandenbroucke, V., Henrion, L., Martinez Alvarez, J. A., & Delvigne, F. (07 December 2022). Managing bacterial growth through external control of synthetic gene circuits [Poster presentation]. Emerging Applications of Microbes (2nd edition), Leuven, Belgium.

Martinez Alvarez, J. A., Delvenne, M., Henrion, L., Moreno, F., Telek, S., Dusny, C., & Delvigne, F. (October 2022). Controlling microbial co-culture based on substrate pulsing can lead to stability through differential fitness advantages. PLoS Computational Biology, 18 (10), 1010674. doi:10.1371/journal.pcbi.1010674
Peer Reviewed verified by ORBi

Vandenbroucke, V., Vandenbroucke, V., Henrion, L., Moreno Avitia, F., Delvigne, F., & Martinez Alvarez, J. A. (2022). Enabling continuous co-culture bioprocesses (C3BIO) based on oscillating environmental conditions promoting genetic and/or metabolic requirements of individual species [Paper presentation]. Bioproscale 2022 (https://biotechnologie.ifgb.de/bioproscale2022), Berlin, Germany.

Bajoul Kakahi, F., Martinez Alvarez, J. A., Avitia, F. M., Telek, S., Volke, D. C., Wirth, N. T., Nikel, P. I., & Delvigne, F. (2021). Release of extracellular DNA by<i>Pseudomonas</i>species as a major determinant for biofilm switching and an early indicator for cell population control. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/318675. doi:10.1101/2021.02.11.430776

Nguyen Minh, T., Telek, S., Zicler, A., Martinez Alvarez, J. A., Zacchetti, B., Kopp, J., Slouka, C., Herwig, C., Grünberger, A., & Delvigne, F. (2021). Reducing phenotypic instabilities of a microbial population during continuous cultivation based on cell switching dynamics. Biotechnology and Bioengineering. doi:10.1002/bit.27860
Peer Reviewed verified by ORBi

Bulté, D. B., Palomares, L. A., Parra, C. G., Martinez Alvarez, J. A., Contreras, M. A., Noriega, L. G., & Ramírez, O. T. (September 2020). Overexpression of the mitochondrial pyruvate carrier reduces lactate production and increases recombinant protein productivity in CHO cells. Biotechnology and Bioengineering, 117 (9), 2633 - 2647. doi:10.1002/bit.27439
Peer Reviewed verified by ORBi

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