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Van Laethem Thomas

CIRM

See author's contact details
ORCID
0000-0002-9556-3521
Main Referenced Co-authors
Hubert, Cédric  (21)
Hubert, Philippe  (20)
Sacre, Pierre-Yves  (15)
Fillet, Marianne  (14)
Kumari, Priyanka  (14)
Main Referenced Keywords
QSRR (4); Analytical Chemistry (3); LC-MS/MS (3); Pharmaceutical Science (3); Random Forest (3);
Main Referenced Unit & Research Centers
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège [BE] (11)
LCAP (1)
Main Referenced Disciplines
Pharmacy, pharmacology & toxicology (18)
Chemistry (3)

Publications (total 21)

The most downloaded
35 downloads
Zhang, Y., Houari, S., Van Laethem, T., Dispas, A., Hubert, P., & Hubert, C. (31 January 2024). Development and validation of an LC-MS/MS method for screening and quantification of trace N-nitrosamines in a pharmaceutical formulation [Paper presentation]. CIRM-day. https://hdl.handle.net/2268/313463

The most cited

3 citations (Scopus®)

Horne, J., De Bleye, C., Lebrun, P., Kemik, K., Van Laethem, T., Sacre, P.-Y., Hubert, P., Hubert, C.* , & Ziemons, E.*. (2023). Optimization of silver nanoparticles synthesis by chemical reduction to enhance SERS quantitative performances: early characterization using the quality by design approach. Journal of Pharmaceutical and Biomedical Analysis, 115475. doi:10.1016/j.jpba.2023.115475 https://hdl.handle.net/2268/303005

Zhang, Y., Houari, S., Van Laethem, T., Dispas, A., Hubert, P., & Hubert, C. (31 January 2024). Development and validation of an LC-MS/MS method for screening and quantification of trace N-nitrosamines in a pharmaceutical formulation [Paper presentation]. CIRM-day.

Kumari, P., Van Laethem, T., Duroux, D., Fillet, M., Hubert, P., Sacre, P.-Y., & Hubert, C. (04 September 2023). A multi-target QSRR approach to model retention times of small molecules in RPLC. Journal of Pharmaceutical and Biomedical Analysis, 236, 115690. doi:10.1016/j.jpba.2023.115690
Peer Reviewed verified by ORBi

Zhang, Y., Van Laethem, T., Ziémons Thibault, Dispas, A., Hubert, P., & Hubert, C. (2023). Détermination de nitrosamines dans une matrice médicamenteuse par LC-MS/MS : préparation d’échantillon et défis analytiques.

Horne, J., De Bleye, C., Lebrun, P., Kemik, K., Van Laethem, T., Sacre, P.-Y., Hubert, P., Hubert, C.* , & Ziemons, E.*. (2023). Optimization of silver nanoparticles synthesis by chemical reduction to enhance SERS quantitative performances: early characterization using the quality by design approach. Journal of Pharmaceutical and Biomedical Analysis, 115475. doi:10.1016/j.jpba.2023.115475
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Zhang, Y., Thibault, Z., Van Laethem, T., Dispas, A., Hubert, C., & Hubert, P. (27 April 2023). In-silico-assisted development of LC-MS/MS methods for the determination of 17 N-nitrosamines in a drug matrix [Paper presentation]. 21st FORUM OF PHARMACEUTICAL SCIENCES.

Zhang, Y., Van Laethem, T., Ziémons, T., Dispas, A., Hubert, P., & Hubert, C. (28 March 2023). Développement assisté in silico d’une méthode LC-MS/MS pour la détermination de 17 nitrosamines dans une matrice médicamenteuse [Paper presentation]. 15ème Congrès de l'Association Francophone des Sciences Séparatives (SEP23), Paris, France.

Kumari, P., Van Laethem, T., Hubert, P., Fillet, M., Sacre, P.-Y., & Hubert, C. (10 February 2023). Quantitative Structure Retention-Relationship Modeling: Towards an Innovative General-Purpose Strategy. Molecules, 28 (4), 1696. doi:10.3390/molecules28041696
Peer reviewed

Priyanka Kumari, Van Laethem, T., Hubert, P., Fillet, M., Sacre, P.-Y., & Hubert, C. (01 February 2023). A multi-target QSRR(mT-QSRR) approach to model retention time of small pharmaceutical compounds in RPLC [Paper presentation]. CIRM DAY 2023, Liege, Belgium.

Zhang, Y., Ziémons, T., Van Laethem, T., Dispas, A., Hubert, P., & Hubert, C. (01 February 2023). In-silico-assisted development of LC-MS/MS methods for the determination of 17 N-nitrosamines in a drug matrix [Paper presentation]. CIRM-day.

Van Laethem, T., Kumari, P., Boulanger, B., Hubert, P., Fillet, M., Sacre, P.-Y., & Hubert, C. (28 November 2022). User-Driven Strategy for In Silico Screening of Reversed-Phase Liquid Chromatography Conditions for Known Pharmaceutical-Related Small Molecules. Molecules, 27 (23), 8306. doi:10.3390/molecules27238306
Peer Reviewed verified by ORBi

Kumari, P., Van Laethem, T., Hubert, P., Fillet, M., Sacre, P.-Y., & Hubert, C. (04 July 2022). QSRR for small pharmaceutical compounds in RPLC: A Machine learning approach [Paper presentation]. 18th Chemometrics in Analytical Chemistry Conference, Rome, Italy.

Van Laethem, T., Kumari, P., Hubert, P., Fillet, M., Sacre, P.-Y., & Hubert, C. (June 2022). A pharmaceutical-related molecules dataset for reversed-phase chromatography retention time prediction built on combining pH and gradient time conditions. Data in Brief, 42, 108017. doi:10.1016/j.dib.2022.108017
Peer Reviewed verified by ORBi

Van Laethem, T., Kumari, P., Fillet, M., Hubert, P., Hubert, C., & Sacre, P.-Y. (18 May 2022). In-silico screening for the development of robust reversed-phase liquid chromatography methods of known small molecules based on QSRR and desirability index [Paper presentation]. 17th International Symposium on Hyphenated Techniques in Chromatography and Separation Technology (HTC-17), Gent, Belgium.
Peer reviewed

Van Laethem, T., Kumari, P., Fillet, M., Hubert, P., Hubert, C., & Sacre, P.-Y. (02 February 2022). Elaboration of a strategy for in silico screening for reversed-phase liquid chromatography method development [Paper presentation]. CIRM-day 2022, Liège, Belgium.

Van Laethem, T., Kumari, P., Fillet, M., Hubert, P., Hubert, C., & Sacre, P.-Y. (05 October 2021). Modélisation du temps de rétention de petites molécules pharmaceutiques en chromatographie liquide en phase inverse basée sur le QSRR et les surfaces de réponse [Poster presentation]. 14ème Congrès Francophone sur les Sciences Séparatives et les Couplages de l'AFSEP, Paris, France.
Peer reviewed

Kumari, P., Van Laethem, T., Hubert, P., Fillet, M., Hubert, C., & Sacre, P.-Y. (22 July 2021). A QSRR modelling of small pharmaceutical compounds in Reverse Phase Liquid Chromatography [Paper presentation]. MLSS 2021 TAIPEI (Machine Learning Summer School), TAIPEI, Taiwan.

Van Laethem, T., Kumari, P., Hubert, P., Fillet, M., Hubert, C., & Sacre, P.-Y. (24 May 2021). Adaptive response surface model of small pharmaceutical compounds in reverse phase liquid chromatography [Paper presentation]. CIRM-day 2021, Liège, Belgium.

Kumari, P., Van Laethem, T., Hubert, P., Fillet, M., Hubert, C., & Sacre, P.-Y. (03 February 2021). Quantitative structure-retention relationship modelling of small pharmaceutical compounds in reverse phase liquid chromatography [Paper presentation]. Chimiométrie.

Kumari, P., Van Laethem, T., Hubert, P., Fillet, M., Hubert, C., & Sacre, P.-Y. (03 February 2021). Quantitative structure-retention relationship modelling of small pharmaceutical compounds in reverse phase liquid chromatography [Paper presentation]. e-CHIMIOMETRIE 2021.
Peer reviewed

Kumari, P., Van Laethem, T., Hubert, P., Fillet, M., Sacre, P.-Y., & Hubert, C. (2021). QSRR modelling of small pharmaceutical compounds in Liquid Chromatography [Paper presentation]. Summer Research internship, Milan, Italy.

Hubert, C., Deidda, R., Dispas, A., Van Laethem, T., Zhao, X., Lebrun, P., & Hubert, P. (28 January 2020). Implementing principles of Analytical Quality by Design (AQbD) for method development in quality control environment [Paper presentation]. 16th International Symposium on Hyphenated Techniques in Chromatography and Separation technology, Ghent, Belgium.

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