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  2. Profile of Romain Vitello (ULiège)
Profil

Vitello Romain

CIRM

See author's contact details
ORCID
0000-0002-4027-5207
Main Referenced Co-authors
Liégeois, Jean-François  (24)
Seutin, Vincent  (12)
Taouba, Hossein  (9)
Brans, Alain  (8)
Kerff, Frédéric  (6)
Main Referenced Keywords
SK channels (16); AlphaFold (4); Binding Assay (4); Ion channels (3); Medicinal Chemistry (3);
Main Referenced Unit & Research Centers
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège (16)
Center for Interdisciplinary Research on Medicines (1)
Giga Neurosciences - ULiège (1)
Main Referenced Disciplines
Pharmacy, pharmacology & toxicology (18)
Biochemistry, biophysics & molecular biology (10)
Chemistry (1)
Physical, chemical, mathematical & earth Sciences: Multidisciplinary, general & others (1)

Publications (total 29)

The most downloaded
441 downloads
Jehasse, K., Massotte, L., Hartmann, S., Vitello, R., Ringlet, S., Vitello, M., Chua, H. C., Pless, S., Engel, D., Liégeois, J.-F., Lakaye, B., Roeper, J., & Seutin, V. (01 October 2021). The gating pore blocker 1-(2,4-xylyl)guanidinium selectively inhibits pacemaking of midbrain dopaminergic neurons. Neuropharmacology, 197, 1-15. doi:10.1016/j.neuropharm.2021.108722 https://hdl.handle.net/2268/267117

The most cited

5 citations (OpenAlex)

Jehasse, K., Massotte, L., Hartmann, S., Vitello, R., Ringlet, S., Vitello, M., Chua, H. C., Pless, S., Engel, D., Liégeois, J.-F., Lakaye, B., Roeper, J., & Seutin, V. (01 October 2021). The gating pore blocker 1-(2,4-xylyl)guanidinium selectively inhibits pacemaking of midbrain dopaminergic neurons. Neuropharmacology, 197, 1-15. doi:10.1016/j.neuropharm.2021.108722 https://hdl.handle.net/2268/267117

Vitello, R. (2025). Towards better SK tools: improving the SK pharmacophore model [Doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/332176

Taouba, H., Vitello, R., Miao, Z., Seutin, V., & Liégeois, J.-F. (29 November 2024). The renal vasodilatory effect of boldine is not related to a direct interaction with SK channels [Paper presentation]. Autumn Meeting 2024 of the Belgian Society of Physiology and Pharmacology, Brussel, Belgium.

Mouchet, A., Nadenoen, T., Vitello, R., Brans, A., Seutin, V., Liégeois, J.-F., & Kerff, F. (15 November 2024). New insight into the modulatory role of the S3-S4 loop in SK2/3 potassium channels [Poster presentation]. SFMBBM (Structure and Function of Biological Macromolecules, Bioinformatics, and Modelling) PhD Day 2024, Namur, Belgium.
Editorial reviewed

Hayen, J.-L., Pereira Barbon, D., Herbet, C., Vitello, R., Tumanov, N., Wouters, J., Kerff, F., & Liégeois, J.-F. (03 July 2024). SYNTHESIS AND CHIRAL SEPARATION OF NEW BENZYLOXY ANALOGUES OF TWO SK CHANNEL-BLOCKING ALKALOIDS: NML AND AG525 [Poster presentation]. RICT 2024 - 58th International Conference on Medicinal Chemistry, Bordeaux, France.

Mouchet, A., Nadenoen, T., Vitello, R., Brans, A., Seutin, V., Liégeois, J.-F., & Kerff, F. (23 May 2024). Investigating the structure and pharmacology of SK channels using a dual biological and structural strategy [Poster presentation]. Instruct-ERIC Biennial Structural Biology Conference 2024, Cascais, Portugal.
Editorial reviewed

Mouchet, A., Nadenoen, T., Vitello, R., Brans, A., Seutin, V., Liégeois, J.-F., & Kerff, F. (26 April 2024). Investigating the structure and pharmacology of SK channels through molecular docking and in vitro patch clamp [Poster presentation]. National Committee of Physiology and Pharmacology : 2024 Spring Meeting, Bruxelles, Belgium.
Editorial reviewed

Vitello, R.* , Taouba, H.* , Derand, M., & Liégeois, J.-F. (2024). The Bis(1,2,3,4-tetrahydroisoquinoline) Alkaloids Cepharanthine and Berbamine Are Ligands of SK Channels. ACS Medicinal Chemistry Letters. doi:10.1021/acsmedchemlett.3c00452
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Freuville, L., Gobbi Amorim, F., Vitello, R., Fourmy, R., Violette, A., Liégeois, J.-F., Brans, A., & Quinton, L. (07 September 2023). Towards a high-throughput mass spectrometry methodology to fish peptide toxins from crude venoms by affinity capture on cell membrane receptors [Poster presentation]. 39ème Journées Françaises de Spectrométrie de Masse, Marseille, France.

Vitello, R., Taouba, H., Pereira Barbon, D., Tumanov, N., Wouters, J., Seutin, V., & Liégeois, J.-F. (10 May 2023). Tetrahydroisoquinoline derivatives as blockers of SK channels: A new pharmacophore identified [Poster presentation]. Cambridge Ion Channels Forum 2023, Cambridge, United Kingdom.

Taouba, H., Vitello, R., Frederich, M., Wouters Johan, & Liégeois, J.-F. (28 April 2023). SMALL-CONDUCTANCE Ca2+-ACTIVATED K+ CHANNELS, A NOVEL TARGET FOR THE ALKALOIDS CEPHARANTHINE AND BERBAMINE [Paper presentation]. 21st FORUM OF PHARMACEUTICAL SCIENCES, Blankenberge, Belgium.

Vitello, R., Taouba, H., Pereira Barbon, D., Tumanov, N., Wouters, J., Seutin, V., & Liégeois, J.-F. (28 April 2023). A Not-So-Simple Simplifictaion [Poster presentation]. PhysPhar Spring meeting 2023, Bruxelles, Belgium.

Falinski, S. P., Taouba, H., Vitello, R., & Liégeois, J.-F. (01 February 2023). The prospect of using a thallium flux assay to study native and mutated hSK2 & hSK3 channels in transiently transfected HEK293 cells [Poster presentation]. CIRM Day 2023, Liège, Belgium.
Editorial reviewed

Taouba, H., Vitello, R., & Liégeois, J.-F. (01 February 2023). CEPHARANTHINE AND BERBAMINE HAVE A SIGNIFICANT AFFINITY FOR THE SMALL CONDUCTANCE Ca 2+ - ACTIVATED K+ CHANNELS [Paper presentation]. C.I.R.M. day 2023, Liège, Belgium.

Freuville, L., Gobbi Amorim, F., Vitello, R., Fourmy, R., Violette, A., Liégeois, J.-F., Brans, A., & Quinton, L. (18 October 2022). Towards a high-throughput MS methodology to fish peptide toxins from crude venoms by affinity capture on cell membrane receptors [Paper presentation]. Congrès International de Toxinologie - IST, Abu-Dhabi, United Arab Emirates.

Freuville, L., Gobbi Amorim, F., Vitello, R., Fourmy, R., Violette, A., Liégeois, J.-F., Brans, A., & Quinton, L. (07 October 2022). Towards a high-throughput mass spectrometry methodology to fish peptide toxins from crude venoms by affinity capture on cell membrane receptors [Poster presentation]. BSMS 2022, Braine l'Alleud, Belgium.

Mouchet, A., Vitello, R., Falinski, S. P., Robaye, L., Liégeois, J.-F., Seutin, V., Brans, A., & Kerff, F. (09 September 2022). Structural and biological approaches to further understand the physiology and pharmacology of the SK channels [Poster presentation]. 2022 Interuniversity PhD Student Day, Namur, Belgium.
Editorial reviewed

Freuville, L., Gobbi Amorim, F., Vitello, R., Fourmy, R., Violette, A., Liégeois, J.-F., Brans, A., & Quinton, L. (01 September 2022). HIGH-THROUGHPUT MASS SPECTROMETRY METHODOLOGY TO FISH PEPTIDE TOXINS FROM CRUDE VENOMS BY AFFINITY CAPTURE ON CELL MEMBRANE RECEPTORS [Paper presentation]. 2022 International Mass Spectrometry Conference, Maastricht, Netherlands.

Vitello, R. (29 June 2022). New structural investigations around the pore of SK Channels [Paper presentation]. Conférence interne CIRM ULiège, Liège, Belgium.

Taouba, H., Vitello, R., Lumb, J.-P., Seutin, V., Frederich, M., & Liégeois, J.-F. (19 November 2021). A NEW APPROACH FOR THE TREATMENT OF MALARIA THROUGH SK CHANNEL MODULATION ? [Poster presentation]. MedChem 2021, Liège, Belgium.

Jehasse, K., Massotte, L., Hartmann, S., Vitello, R., Ringlet, S., Vitello, M., Chua, H. C., Pless, S., Engel, D., Liégeois, J.-F., Lakaye, B., Roeper, J., & Seutin, V. (01 October 2021). The gating pore blocker 1-(2,4-xylyl)guanidinium selectively inhibits pacemaking of midbrain dopaminergic neurons. Neuropharmacology, 197, 1-15. doi:10.1016/j.neuropharm.2021.108722
Peer Reviewed verified by ORBi

Vitello, R., Seutin, V., Badarau, E., & Liégeois, J.-F. (28 May 2021). Benzhydrol analogues of bis-isoquinoliniums : chiral entities with potential to interact with SK channels [Paper presentation]. 2nd FNRS Med Chem Symposium, Belgium.

Taouba, H., Vitello, R., Lumb, J.-P., Seutin, V., Frederich, M., & Liégeois, J.-F. (26 May 2021). Could Bis-THIQ compounds inhibit plasmodial growth through SK channel interaction ? [Poster presentation]. CIRM-day, LIEGE, Belgium.

Wanko Nembot, A. M., Hayen, J.-L., Vitello, R., Damblon, C., & Liégeois, J.-F. (26 May 2021). Quantification of 2-disulfide bonded isomers of apamin, a peptidic toxin, leads to the observation of a structural rearrangement [Poster presentation]. CIRM-Day.

Vitello, R., Kerff, F., & Liégeois, J.-F. (2021). Deciphering the molecular mechanism of SK2 channel activation by intracellular calcium to develop new therapeutic agents. Acta Physiologica, 231, 13574. doi:10.1111/apha.13574
Peer reviewed

Vitello, R. (15 December 2020). New pharmacological tools for SK channels [Paper presentation]. GIGA doctoral school for health sciences (year 2020).

Jehasse, K., Massotte, L., Hartmann, S., Vitello, R., Ringlet, S., Lakaye, B., Liégeois, J.-F., Roeper, J., & Seutin, V. (22 May 2020). On the path to understanding pacemaking of dopaminergic neurons [Poster presentation]. Virtual Dopamine Meeting.

Vitello, R. (2020). Communication orale de vulgarisation scientifique : De nouveaux outils pour la santé mentale.

Vitello, R. (2018). Development of new derivatives of a natural alkaloid, Crispine E, as SK channel blockers [Master’s dissertation, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/248307

Vitello, R., & Liégeois, J.-F. (23 February 2017). Chiral tools to explore SK channel functions [Paper presentation]. CIRM seminar.

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