Malignant catarrhal fever induced by Alcelaphine herpesvirus 1 is characterized by an expansion of activated CD3+CD8+CD4- T cells expressing a cytotoxic phenotype in both lymphoid and non-lymphoid tissues.
[en] ABSTRACT: Alcelaphine herpesvirus 1 (AlHV-1) is carried by wildebeest asymptomatically. It causes a fatal lymphoproliferative disease named wildebeest-derived malignant catarrhal fever (WD-MCF) when cross-species transmitted to a variety of susceptible species of the Artiodactyla order. WD-MCF can be reproduced experimentally in rabbits. In a previous report, we demonstrated that WD-MCF induced by AlHV-1 is associated with a severe proliferation of CD8+ T cells in the lymphoid tissues. Here, we further studied the mononuclear leukocytic populations in both the lymphoid (throughout the infection and at time of euthanasia) and non-lymphoid (at time of euthanasia) organs during WD-MCF induced experimentally in rabbits. To reach that goal, we performed multi-colour flow cytometry stainings. The results obtained demonstrate that the development of WD-MCF correlates in peripheral blood with a severe increase of CD8+ cell percentages; and that CD3+CD8+CD4- T cells were the predominant cell type in both lymphoid and non-lymphoid organs at time of euthanasia. Further characterization of the mononuclear leukocytes isolated from both lymphoid and non-lymphoid tissues revealed that the CD8+ T cells express high levels of the activation markers CD25 and CD44, produce high amount of gamma-interferon (IFN-gamma) and perforin, and showed a reduction of interleukin-2 (IL-2) gene expression. These data demonstrate that the development of WD-MCF is associated with the expansion and infiltration of activated and cytotoxic CD3+CD8+CD4- T cells secreting high amount of IFN-gamma but low IL-2.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Dewals, Benjamin G ; Université de Liège - ULiège > Immunologie et vaccinologie
Malignant catarrhal fever induced by Alcelaphine herpesvirus 1 is characterized by an expansion of activated CD3+CD8+CD4- T cells expressing a cytotoxic phenotype in both lymphoid and non-lymphoid tissues.
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
Blue wildebeest and the aetiological agent of bovine malignant catarrhal fever. Plowright W, Ferris RD, Scott GR, Nature 1960 188 1167 1169 10.1038/1881167a0 13736396
Maasai perception of the impact and incidence of malignant catarrhal fever (MCF) in southern Kenya. Bedelian C, Nkedianye D, Herrero M, Prev Vet Med 2007 78 296 316 10.1016/j.prevetmed.2006.10.012 17123651 (Pubitemid 46135777)
Cleaveland S, Kusiluka L, ole Kuway J, Bell C, Kazwala R, Assessing the impact of malignant catarrhal fever in Ngorongoro district, Tanzania Community-based Animal Health and Participatory Epidemiology Unit (CAPE), OAU 2001
Ultrastructure of cellular changes in the replication of the alcelaphine herpesvirus-1 of malignant catarrhal fever. Castro AE, Heuschele WP, Schramke ML, Dotson JF, Am J Vet Res 1985 46 1231 1237 4040722
Transmission of malignant catarrhal fever to rabbits. Buxton D, Reid HW, Vet Rec 1980 106 243 245 10.1136/vr.106.11.243 7189075
The nature of the acute lymphoid proliferation in rabbits infected with the herpes virus of bovine malignant catarrhal fever. Edington N, Patel J, Russell PH, Plowright W, Eur J Cancer 1979 15 1515 1522 575332 (Pubitemid 10214262)
Malignant catarrhal fever. Plowright W, J Am Vet Med Assoc 1968 152 795 803
Characterisation of the lymphoproliferation in rabbits experimentally affected with malignant catarrhal fever. Schock A, Reid HW, Vet Microbiol 1996 53 111 119 10.1016/S0378-1135(96)01239-4 9011003 (Pubitemid 27013949)
Constitutive activation of Lck and Fyn tyrosine kinases in large granular lymphocytes infected with the gamma-herpesvirus agents of malignant catarrhal fever. Swa S, Wright H, Thomson J, Reid H, Haig D, Immunology 2001 102 44 52 10.1046/j.1365-2567.2001.01154.x 11168636 (Pubitemid 32142513)
Malignant catarrhal fever induced by alcelaphine herpesvirus 1 is associated with proliferation of CD8+ T cells supporting a latent infection. Dewals B, Boudry C, Farnir F, Drion PV, Vanderplasschen A, PLoS One 2008 3 1627 10.1371/journal.pone.0001627 18286184 (Pubitemid 351850990)
Surface marker analysis of the vascular and epithelia lesions in cattle with sheep-associated malignant catarrhal fever. Nakajima Y, Ishikawa Y, Kadota K, Kodama M, Honma Y, J Vet Med Sci 1994 56 1065 1068 10.1292/jvms.56.1065 7696393
Immunohistochemical study of experimental malignant catarrhal fever in rabbits. Anderson IE, Buxton D, Campbell I, Russell G, Davis WC, Hamilton MJ, Haig DM, J Comp Pathol 2007 136 156 166 10.1016/j.jcpa.2007.01.007 17374379 (Pubitemid 46552885)
The vascular lesions of a cow and bison with sheep-associated malignant catarrhal fever contain ovine herpesvirus 2-infected CD8(+) T lymphocytes. Simon S, Li H, O'Toole D, Crawford TB, Oaks JL, J Gen Virol 2003 84 2009 2013 10.1099/vir.0.19048-0 12867630 (Pubitemid 36927229)
Malignant catarrhal fever: a review. Russell GC, Stewart JP, Haig DM, Vet J 2009 179 324 335 10.1016/j.tvjl.2007.11.007 18760944
Malignant catarrhal fever of cattle is associated with low abundance of IL-2 transcript and a predominantly latent profile of ovine herpesvirus 2 gene expression. Meier-Trummer CS, Rehrauer H, Franchini M, Patrignani A, Wagner U, Ackermann M, PLoS One 2009 4 6265 10.1371/journal.pone.0006265 19603070
Immunisation of cattle against the herpesvirus of malignant catarrhal fever: failure of inactivated culture vaccines with adjuvant. Plowright W, Herniman KA, Jessett DM, Kalunda M, Rampton CS, Res Vet Sci 1975 19 159 166 1166120
Detection of T and B cells in many animal species using cross-reactive anti-peptide antibodies. Jones M, Cordell JL, Beyers AD, Tse AG, Mason DY, J Immunol 1993 150 5429 5435 8515069 (Pubitemid 23180656)
The A5 gene of alcelaphine herpesvirus 1 encodes a constitutively active G-protein-coupled receptor that is non-essential for the induction of malignant catarrhal fever in rabbits. Boudry C, Markine-Goriaynoff N, Delforge C, Springael JY, de Leval L, Drion P, Russell G, Haig DM, Vanderplasschen AF, Dewals B, J Gen Virol 2007 88 3224 3233 10.1099/vir.0.83153-0 18024890 (Pubitemid 350201831)
Cloning of the genome of Alcelaphine herpesvirus 1 as an infectious and pathogenic bacterial artificial chromosome. Dewals B, Boudry C, Gillet L, Markine-Goriaynoff N, de Leval L, Haig DM, Vanderplasschen A, J Gen Virol 2006 87 509 517 10.1099/vir.0.81465-0 16476972
Myxoma virus M141R expresses a viral CD200 (vOX-2) that is responsible for down-regulation of macrophage and T-cell activation in vivo. Cameron CM, Barrett JW, Liu L, Lucas AR, McFadden G, J Virol 2005 79 6052 6067 10.1128/JVI.79.10.6052-6067.2005 15857991 (Pubitemid 40617211)
Diversity in T cell memory: an embarrassment of riches. Jameson SC, Masopust D, Immunity 2009 31 859 871 10.1016/j.immuni.2009.11.007 20064446
Isolation of bovine malignant catarrhal fever virus from ocular and nasal secretions of wildebeest calves. Mushi EZ, Karstad L, Jessett DM, Res Vet Sci 1980 29 168 171 7193339 (Pubitemid 11254970)
The demonstration of cell-free malignant catarrhal fever herpesvirus in wildebeest nasal secretions. Mushi EZ, Rossiter PB, Karstad L, Jessett DM, J Hyg (Lond) 1980 85 175 179 10.1017/S0022172400063208 (Pubitemid 11253269)
An immunisation strategy for the protection of cattle against alcelaphine herpesvirus-1-induced malignant catarrhal fever. Haig DM, Grant D, Deane D, Campbell I, Thomson J, Jepson C, Buxton D, Russell GC, Vaccine 2008 26 4461 4468 10.1016/j.vaccine.2008.06.056 18601965
Preliminary characterization of the alcelaphine herpesvirus 1 genome. Bridgen A, Herring AJ, Inglis NF, Reid HW, J Gen Virol 1989 70 Pt 5 1141 1150 2732713 (Pubitemid 19131623)
Proteomic analysis of pathogenic and attenuated alcelaphine herpesvirus 1. Dry I, Haig DM, Inglis NF, Imrie L, Stewart JP, Russell GC, J Virol 2008 82 5390 5397 10.1128/JVI.00094-08 18353942 (Pubitemid 351705246)
CD8(+)/perforin(+)/WC1(-) gamma delta T cells, not CD8(+) alpha beta T cells, infiltrate vasculitis lesions of American bison (Bison bison) with experimental sheep-associated malignant catarrhal fever. Nelson DD, Davis WC, Brown WC, Li H, O'Toole D, Oaks JL, Vet Immunol Immunopathol 2010 136 284 291 10.1016/j.vetimm.2010.03.023 20413164
Phenotype, growth regulation and cytokine transcription in Ovine Herpesvirus-2 (OHV-2)-infected bovine T-cell lines. Schock A, Collins RA, Reid HW, Vet Immunol Immunopathol 1998 66 67 81 10.1016/S0165-2427(98)00187-1 9847021 (Pubitemid 28535470)
Immunopathology of interleukin (IL) 2-deficient mice: thymus dependence and suppression by thymus-dependent cells with an intact IL-2 gene. Kramer S, Schimpl A, Hunig T, J Exp Med 1995 182 1769 1776 10.1084/jem.182.6.1769 7500021
Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Schorle H, Holtschke T, Hunig T, Schimpl A, Horak I, Nature 1991 352 621 624 10.1038/352621a0 1830926 (Pubitemid 21912393)
CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. Malek TR, Yu A, Vincek V, Scibelli P, Kong L, Immunity 2002 17 167 178 10.1016/S1074-7613(02) 00367-9 12196288 (Pubitemid 35245959)
Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. Almeida AR, Legrand N, Papiernik M, Freitas AA, J Immunol 2002 169 4850 4860 12391195 (Pubitemid 35217148)
Pathogenesis of 'sheep-associated' malignant catarrhal fever in rabbits. Buxton D, Reid HW, Finlayson J, Pow I, Res Vet Sci 1984 36 205 211 6609389
Ex Vivo Bioluminescence Detection of Alcelaphine Herpesvirus 1 Infection during Malignant Catarrhal Fever. Dewals B, Myster F, Palmeira L, Gillet L, Ackermann M, Vanderplasschen A, J Virol 2011 85 6941 6954 10.1128/JVI.00286-11 21593175
Viral degradation of the MHC class I peptide loading complex. Boname JM, de Lima BD, Lehner PJ, Stevenson PG, Immunity 2004 20 305 317 10.1016/S1074-7613(04)00047-0 15030774 (Pubitemid 38388232)
Immune evasion by a novel family of viral PHD/LAP-finger proteins of gamma-2 herpesviruses and poxviruses. Fruh K, Bartee E, Gouveia K, Mansouri M, Virus Res 2002 88 55 69 10.1016/S0168-1702(02)00120-X 12297327 (Pubitemid 35251899)
A CD8+ T cell immune evasion protein specific to Epstein-Barr virus and its close relatives in Old World primates. Hislop AD, Ressing ME, van Leeuwen D, Pudney VA, Horst D, Koppers-Lalic D, Croft NP, Neefjes JJ, Rickinson AB, Wiertz EJ, J Exp Med 2007 204 1863 1873 10.1084/jem.20070256 17620360 (Pubitemid 47236322)
Gamma-herpesvirus latency requires T cell evasion during episome maintenance. Bennett NJ, May JS, Stevenson PG, PLoS Biol 2005 3 120 10.1371/journal.pbio.0030120 15769185 (Pubitemid 40721157)
Immune control of mammalian gamma-herpesviruses: lessons from murid herpesvirus-4. Stevenson PG, Simas JP, Efstathiou S, J Gen Virol 2009 90 2317 2330 10.1099/vir.0.013300-0 19605591
An optimized CD4 T-cell response can control productive and latent gammaherpesvirus infection. Sparks-Thissen RL, Braaten DC, Kreher S, Speck SH, Virgin HW 4th, J Virol 2004 78 6827 6835 10.1128/JVI.78.13.6827-6835.2004 15194758 (Pubitemid 38781520)
Murine gamma-herpesvirus 68 causes severe large-vessel arteritis in mice lacking interferon-gamma responsiveness: a new model for virus-induced vascular disease. Weck KE, Dal Canto AJ, Gould JD, O'Guin AK, Roth KA, Saffitz JE, Speck SH, Virgin HW, Nat Med 1997 3 1346 1353 10.1038/nm1297-1346 9396604 (Pubitemid 28011034)
Pathological changes in the spleens of gamma interferon receptor-deficient mice infected with murine gammaherpesvirus: a role for CD8 T cells. Dutia BM, Clarke CJ, Allen DJ, Nash AA, J Virol 1997 71 4278 4283 9151815 (Pubitemid 27204114)
Selection of rabbit CD4- CD8- T cell receptor-gamma/delta cells by in vitro transformation with human T lymphotropic virus-I. Sawasdikosol S, Hague BF, Zhao TM, Bowers FS, Simpson RM, Robinson M, Kindt TJ, J Exp Med 1993 178 1337 1345 10.1084/jem.178.4.1337 8376938 (Pubitemid 23277365)
Granzyme B and perforin: constitutive expression in human polymorphonuclear neutrophils. Wagner C, Iking-Konert C, Denefleh B, Stegmaier S, Hug F, Hansch GM, Blood 2004 103 1099 1104 14512315 (Pubitemid 38129577)
Regulation of FAS ligand expression by chemokine ligand 2 in human endometrial cells. Selam B, Kayisli UA, Akbas GE, Basar M, Arici A, Biol Reprod 2006 75 203 209 10.1095/biolreprod.105.045716 16687653 (Pubitemid 44107189)
Quantitation of rabbit cytokine mRNA by real-time RT-PCR. Godornes C, Leader BT, Molini BJ, Centurion-Lara A, Lukehart SA, Cytokine 2007 38 1 7 10.1016/j.cyto.2007.04.002 17521914 (Pubitemid 46990919)
Similar publications
Sorry the service is unavailable at the moment. Please try again later.
This website uses cookies to improve user experience. Read more
Save & Close
Accept all
Decline all
Show detailsHide details
Cookie declaration
About cookies
Strictly necessary
Performance
Strictly necessary cookies allow core website functionality such as user login and account management. The website cannot be used properly without strictly necessary cookies.
This cookie is used by Cookie-Script.com service to remember visitor cookie consent preferences. It is necessary for Cookie-Script.com cookie banner to work properly.
Performance cookies are used to see how visitors use the website, eg. analytics cookies. Those cookies cannot be used to directly identify a certain visitor.
Used to store the attribution information, the referrer initially used to visit the website
Cookies are small text files that are placed on your computer by websites that you visit. Websites use cookies to help users navigate efficiently and perform certain functions. Cookies that are required for the website to operate properly are allowed to be set without your permission. All other cookies need to be approved before they can be set in the browser.
You can change your consent to cookie usage at any time on our Privacy Policy page.
