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Interactions between Tumoral Mcf7 Cells and Fibroblasts on Matrigel and Purified Laminin
Noël, Agnès; Nusgens, Betty; Lapiere, C. H. et al.
1993In Matrix, 13 (4), p. 267-73
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Abstract :
[en] A reconstituted basement membrane (matrigel) and/or fibroblasts promote the growth of human breast tumors in athymic nude mice. We have investigated in vitro the effect of matrigel or purified glycoproteins (laminin and fibronectin) on tumoral MCF7 cells-fibroblasts interactions. In coculture on matrigel, MCF7 cells organized into clusters attached on top of fibroblasts aggregates. During the process resulting in tumor cells-fibroblasts aggregation, fibroblasts actively migrated while MCF7 cells were passively transported. Using purified proteins, specific antibodies and synthetic peptides, we show that cell aggregation induced by immobilized and soluble laminin is antagonized by exogenous fibronectin or fibronectin synthesized by fibroblasts.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Noël, Agnès ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme
Nusgens, Betty ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Protéines et glycoprot. de matr.extracell. et membran.basal.
Lapiere, C. H.
Foidart, Jean-Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement
Language :
English
Title :
Interactions between Tumoral Mcf7 Cells and Fibroblasts on Matrigel and Purified Laminin
Publication date :
July 1993
Journal title :
Matrix
ISSN :
0934-8832
Publisher :
Gustav Fischer Verlag, Stuttgart, Germany
Volume :
13
Issue :
4
Pages :
267-73
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 March 2009

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