Article (Scientific journals)
Circadian Rhythm of Heart Rate and Heart Rate Variability
Massin, M. M.; Maeyns, K.; Withofs, Nadia et al.
2000In Archives of Disease in Childhood, 83 (2), p. 179-82
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Keywords :
Heart rate; Heart rate variability; Circadian Rhythms
Abstract :
[en] BACKGROUND: Measurements of heart rate variability (HRV) are increasingly used as markers of cardiac autonomic activity. AIM: To examine circadian variation in heart rate and HRV in children. SUBJECTS: A total of 57 healthy infants and children, aged 2 months to 15 years, underwent ambulatory 24 hour Holter recording. Monitoring was also performed on five teenagers with diabetes mellitus and subclinical vagal neuropathy in order to identify the origin of the circadian variation in HRV. METHODS: The following variables were determined hourly: mean RR interval, four time domain (SDNN, SDNNi, rMSSD, and pNN50) and four frequency domain indices (very low, low and high frequency indices, low to high frequency ratio). A chronobiological analysis was made by cosinor method for each variable. RESULTS: A significant circadian variation in heart rate and HRV was present from late infancy or early childhood, characterised by a rise during sleep, except for the low to high frequency ratio that increased during daytime. The appearance of these circadian rhythms was associated with sleep maturation. Time of peak variability did not depend on age. Circadian variation was normal in patients with diabetes mellitus. CONCLUSION: We have identified a circadian rhythm of heart rate and HRV in infants and children. Our data confirm a progressive maturation of the autonomic nervous system and support the hypothesis that the organisation of sleep, associated with sympathetic withdrawal, is responsible for these rhythms.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Massin, M. M.
Maeyns, K.
Withofs, Nadia ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine nucléaire
Ravet, Françoise ;  Université de Liège - ULiège > Département des sciences cliniques
Gérard, Paul ;  Université de Liège - ULiège > Département de mathématique > Statistique (aspects expérimentaux)
Language :
English
Title :
Circadian Rhythm of Heart Rate and Heart Rate Variability
Publication date :
August 2000
Journal title :
Archives of Disease in Childhood
ISSN :
0003-9888
eISSN :
1468-2044
Publisher :
BMJ Publishing Group, United Kingdom
Volume :
83
Issue :
2
Pages :
179-82
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 26 September 2011

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