Cytochrome P450-mediated cardiovascular drug interactions.

[en] Introduction: There are numerous drug-drug interactions (DDIs) related to cardiovascular medications and many of these are mediated via the cytochrome P450 (CYP) system. Some of these may lead to serious adverse events and it is, therefore, essential that clinicians are aware of the important interactions that occur. Areas covered: An extensive literature search was performed to analyze the CYP-mediated cardiovascular DDIs that lead to a loss of efficacy or potential toxicity. Cardiovascular drugs may be victims or act as perpetrators of DDIs. The paper analyzes CYP-mediated drug interactions concerning anticoagulants, antiplatelet agents, antiarrhythmics, beta-blockers, calcium antagonists, antihypertensive medications, lipid-lowering drugs and oral antidiabetic agents. Expert opinion: Cardiovascular DDIs involving the CYP system are numerous. Additionally, the spectrum of drugs prescribed is constantly changing, particularly with cardiovascular diseases and it is not necessarily the case that drugs that had shown safety earlier will always show safety. Clinicians are encouraged to develop their knowledge of CYP-mediated DDIs so that they can choose safe drug combination regimens, adjust drug dosages appropriately and conduct therapeutic drug monitoring for drugs with narrow therapeutic indices.

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

SCHEEN, André ; Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques

Language :

English

Title :

Cytochrome P450-mediated cardiovascular drug interactions.

Publication date :

2011

Journal title :

Expert Opinion on Drug Metabolism and Toxicology

ISSN :

1742-5255

eISSN :

1744-7607

Publisher :

Informa Healthcare, United Kingdom

Volume :

Issue :

Pages :

1065-82

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 20 September 2011

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159 (6 by ULiège)

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4 (2 by ULiège)

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