Shortened irradiation scheme, continuous infusion of 5-fluorouracil and fractionation of mitomycin C in locally advanced anal carcinomas. Results of a phase II study of the European Organization for Research and Treatment of Cancer. Radiotherapy and Gastrointestinal Cooperative Groups
Bosset, J. F.; Roelofsen, F.; Morgan, D. A. L.et al.
2003 • In European Journal of Cancer, 39, p. 45-51
Chemoradiotherapy; Anal cancer; Accelerated treatment; Phase II clinical trial
Abstract :
[en] Abstract
The European Organization for Research and Treatment of Cancer (EORTC) 22861 randomised trial established that combined
radiochemotherapy is the standard treatment for locally advanced anal cancer. This EORTC phase II study (#22953) tests the
feasibility of reducing the gap between sequences to 2 weeks, to deliver Mitomycin C (MMC) in each radiotherapy sequence and
5-FU continuously during the treatment. The first sequence consisted of 36 Gy over 4 weeks. 5-FU 200 mg/m2/days 1–26, MMC 10
mg/m2/day 1 gap 16 days. Then a second sequence of 23.4 Gy over 17 days, 5-FU 200 mg/m2/days 1–17 and, MMC 10 mg/m2/day 1
was given. 43 patients with a World Health Organization (WHO) status of 0 (n=27) or 1 (n=16) and with T2-T4, N0-3 tumours
were included. Compliance with the planned treatment, doses and duration was 93%. The complete response rate was 90.7%.
Grade 3 toxicities of 28, 12 and 2% were observed for skin, diarrhoea and haematological toxicities, respectively. The 3-year estimated
rates for trials 22861 and 22953 are: 68 and 88% for local control; 72 and 81% for colostomy-free interval, 62 and 84% for
severe late toxicity-free interval, and 70 and 81% for survival, respectively. The 22953 scheme is feasible and the results are promising.
This is now considered as the new standard scheme by the EORTC.
Disciplines :
Oncology Hematology
Author, co-author :
Bosset, J. F.; Besançon University Hospital > Radiotherapy > Besançon, France
Roelofsen, F.; Universitatsklinikum > Klinik für Allgemein und Visceralchirurgie > Essen, Germany
Morgan, D. A. L.; City Hospital > Clinical Oncology > Nottingham, UK
Budach, V.
Jager, J. J.
Van der Steen-Banasik, E.; Arnhems Radiotherapy Instituut > Radiotherapy > The Netherlands
Puyraveau, M.; Besançon University Hospital > Radiotherapy Department > Besançon, France
COUCKE, Philippe ; Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland > Radiothérapie
Mercier, M.
Language :
English
Title :
Shortened irradiation scheme, continuous infusion of 5-fluorouracil and fractionation of mitomycin C in locally advanced anal carcinomas. Results of a phase II study of the European Organization for Research and Treatment of Cancer. Radiotherapy and Gastrointestinal Cooperative Groups
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