Reference : Trimethoprim, creatinine and creatinine-based equations
Scientific journals : Article
Human health sciences : Laboratory medicine & medical technology
Trimethoprim, creatinine and creatinine-based equations
DELANAYE, Pierre mailto [Centre Hospitalier Universitaire de Liège - CHU > > Néphrologie >]
CAVALIER, Etienne mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chimie médicale >]
Mariat, Christophe [ > > ]
Maillard, Nicolas [ > > ]
KRZESINSKI, Jean-Marie mailto [Centre Hospitalier Universitaire de Liège - CHU > > Néphrologie >]
White, Christine [ > > ]
Kidney International
Nature Publishing Group
Yes (verified by ORBi)
New York
[en] trimethroprim ; creatinine ; glomerular filtration rate
[en] Co-trimoxazole is a frequently prescribed antibiotic worldwide. It is composed of both trimethoprim and sulfamethoxazol (Sfx) and is used in the treatment and prophylaxis of urinary tract and Pneumocystis jirovecii infections. The Sfx component appears to be nephrotoxic at high doses or doses inappropriately adjusted for glomerular filtration rate
(GFR). The trimethoprim component, even at recommended doses, inhibits tubular creatinine secretion, leading to a rapid but ultimately reversible increase in serum creatinine independent
of any changes in GFR. This translates into a falsely low estimated GFR when creatinine-based equations are used. This review focuses on evidence of the differential effects of trimethoprim and Sfx on serum creatinine concentrations and GFR and their relevance to clinical practice, with particular attention to kidney transplantation.

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