Reference : A non-invasive approach to study lifetime exposure and bioaccumulation of PCBs in pro...
Scientific journals : Article
Life sciences : Environmental sciences & ecology
Life sciences : Aquatic sciences & oceanology
http://hdl.handle.net/2268/97872
A non-invasive approach to study lifetime exposure and bioaccumulation of PCBs in protected marine mammals: PBPK modeling in harbor porpoises
English
Weijs, Liesbeth [Universiteit Antwerpen - UA > > > >]
Covaci, Adrian [Universiteit Antwerpen - UA > > > >]
Yang, Raymond S. H. [Colorado State University > > > >]
Das, Krishna mailto [Université de Liège - ULiège > Département des sciences et gestion de l'environnement > Océanologie >]
Blust, Ronny [Universiteit Antwerpen - UA > >]
2011
Toxicology and Applied Pharmacology
Academic Press
256
136-145
Yes (verified by ORBi)
International
0041-008X
1096-0333
New York
NY
[en] Harbor porpoises ; Metabolism ; PBPK models ; PCBs ; Time trends
[en] In the last decade, physiologically based pharmacokinetic (PBPK) models have increasingly been developed to explain the kinetics of environmental pollutants in wildlife. For marine mammals specifically, these models provide a new, non-destructive tool that enables the integration of biomonitoring activities and in vitro studies. The goals of the present study were firstly to develop PBPK models for several environmental relevant PCB congeners in harbor porpoises (Phocoena phocoena), a species that is sensitive to pollution because of its limited metabolic capacity for pollutant transformation. These models were tested using tissue data of porpoises from the Black Sea. Secondly, the predictive power of the models was investigated for time trends in the PCB concentrations in North Sea harbor porpoises between 1990 and 2008. Thirdly, attempts were made to assess metabolic capacities of harbor porpoises for the investigated PCBs. In general, results show that parameter values from other species (rodents, humans) are not always suitable in marine mammal models, most probably due to differences in physiology and exposure. The PCB 149 levels decrease the fastest in male harbor porpoises from the North Sea in a time period of 18†years, whereas the PCB 101 levels decrease the slowest. According to the models, metabolic breakdown of PCB 118 is probably of lesser importance compared to other elimination pathways. For PCB 101 and 149 however, the presence of their metabolites can be attributed to bioaccumulation of metabolites from the prey and to metabolic breakdown of the parent compounds in the harbor porpoises.
Centre Interfacultaire de Recherches en Océanologie - MARE
Fonds Wetenschappelijk Onderzoek - FWO ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
http://hdl.handle.net/2268/97872
10.1016/j.taap.2011.07.020

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