Le médicament du mois. Le tacrolimus topique (Protopic).

Administration, Cutaneous; Dermatitis, Atopic/drug therapy/immunology/pathology; Drug Tolerance; Humans; Immunosuppressive Agents/immunology/pharmacokinetics/therapeutic use; Risk Factors; Skin Absorption/drug effects; Tacrolimus/immunology/pharmacology/therapeutic use; Th1 Cells/drug effects; Th2 Cells/drug effects; Treatment Outcome

Abstract :

[en] Tacrolimus is a potent inhibitor of immune mechanisms. It belongs to the macrolactam group. It inhibits the release of both Th1 and Th2 cytokines. It proves to be efficacious after topical application in the treatment of atopic dermatitis. In this indication, tacrolimus challenges topical corticosteroids. Irritation risks are present. The local immuno-depression can boost disseminated infections including herpes. The risk to promote photocarcinogenesis on the long term, and that bound to chronic resorption remain theoretical concerns that have not been assessed so far.

Disciplines :

Dermatology

Author, co-author :

Pierard, Gérald ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Pierard, Claudine ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Paquet, Philippe ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Language :

French

Title :

Le médicament du mois. Le tacrolimus topique (Protopic).

Alternative titles :

[en] Drug of month. Topical tacrolimus (Protopic).

Publication date :

2002

Journal title :

Revue Médicale de Liège

ISSN :

0370-629X

eISSN :

2566-1566

Publisher :

Université de Liège. Revue Médicale de Liège, Liège, Belgium

Volume :

Issue :

Pages :

552-5

Peer reviewed :

Peer reviewed

Available on ORBi :

since 26 March 2009

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Bibliography

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