Reference : Ototoxic drugs: difference in sensitivity between mice and guinea pigs.
Scientific journals : Article
Human health sciences : Otolaryngology
Life sciences : Biotechnology
Life sciences : Biochemistry, biophysics & molecular biology
Ototoxic drugs: difference in sensitivity between mice and guinea pigs.
Poirrier, Anne-Lise [Centre Hospitalier Universitaire de Liège - CHU > > O.R.L. >]
Van Den Ackerveken, Priscilla mailto [> > > >]
Kim, T. S. [> > > >]
Vandenbosch, Renaud mailto [Université de Liège - ULiège > > GIGA - Neurosciences >]
Nguyen, Laurent mailto [Université de Liège - ULiège > Département des sciences cliniques > Neurologie >]
Lefèbvre, Philippe mailto [Université de Liège - ULiège > Département des sciences cliniques > Oto-rhino-laryngologie et audiophonologie >]
Malgrange, Brigitte mailto [Université de Liège - ULiège > > GIGA - Neurosciences - Neurologie >]
Toxicology Letters
Yes (verified by ORBi)
The Netherlands
[en] Animals ; Anti-Bacterial Agents/toxicity ; Antineoplastic Agents/toxicity ; Cisplatin/toxicity ; Deafness/chemically induced/pathology ; Drug Toxicity ; Evoked Potentials, Auditory, Brain Stem/drug effects ; Fluorescent Antibody Technique ; Guinea Pigs ; Hearing/drug effects ; Kanamycin/toxicity ; Male ; Mice ; Mice, Inbred BALB C ; Neurons/pathology ; Organ of Corti/pathology ; Species Specificity ; Spiral Ganglion/drug effects/pathology ; Tolonium Chloride
[en] The development of experimental animal models has played an invaluable role in understanding the mechanisms of neurosensory deafness and in devising effective treatments. The purpose of this study was to develop an adult mouse model of ototoxic drug-induced hearing loss and to compare the ototoxicity in the adult mouse to that in the well-described guinea pig model. Mice are a powerful model organism, especially due to the large availability of antibodies, probes and genetic mutants. In this study, mice (n=114) and guinea pigs (n=35) underwent systemic treatment with either kanamycin or cisplatin. Auditory brainstem responses showed a significant threshold shift in guinea pigs 2 weeks after the beginning of the ototoxic treatment, while there was no significant hearing impairment recorded in mice. Hair cells and neuronal loss were correlated with hearing function in both guinea pigs and mice. These results indicate that the mouse is not a good model for ototoxicity, which should be taken into consideration in all further investigations concerning ototoxicity-induced hearing loss.
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Fonds Léon Fredericq
Researchers ; Professionals

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