Reference : Testosterone-induced brain aromatase is sexually dimorphic.
Scientific journals : Article
Life sciences : Zoology
Human health sciences : Endocrinology, metabolism & nutrition
Social & behavioral sciences, psychology : Neurosciences & behavior
Testosterone-induced brain aromatase is sexually dimorphic.
Schumacher, M. [> > > >]
Balthazart, Jacques mailto [ > > ]
Brain Research
Elsevier Science
Yes (verified by ORBi)
The Netherlands
[en] Animals ; Aromatase/biosynthesis ; Brain/enzymology ; Coturnix ; Enzyme Induction ; Estradiol/biosynthesis ; Female ; Kinetics ; Male ; Orchiectomy ; Organ Specificity ; Sex Factors ; Testosterone/metabolism/pharmacology
[en] Female quail are less sensitive than males to the activating effects of testosterone (T) on behavior. Testosterone induces hypothalamic aromatase activity more efficiently in males than in females (higher Vmax but similar Km). As the conversion of T to estradiol (E2) is important for the activation of male sexual behavior, we propose that the incapacity of the female hypothalamus to produce behaviorally active E2 contributes to their insensitivity to T. The 5 alpha-reductase, which converts T into 5 alpha-dihydrotestosterone (5 alpha-DHT), is induced by T specifically in the anterior hypothalamus of both sexes.

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