Reference : Acute neutrophil activation in direct stenting: comparison of stable and unstable ang...
Scientific journals : Article
Human health sciences : Cardiovascular & respiratory systems
Acute neutrophil activation in direct stenting: comparison of stable and unstable angina patients.
Gach, Olivier mailto [Centre Hospitalier Universitaire de Liège - CHU > > Cardiologie >]
Nys, Monique mailto [Centre Hospitalier Universitaire de Liège - CHU > > Soins intensifs - Anesthésie et réanimation >]
Deby, Ginette [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation >]
Chapelle, Jean-Paul [Centre Hospitalier Universitaire de Liège - CHU > > Chimie médicale >]
Lamy, Maurice mailto [Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques >]
Pierard, Luc mailto [Centre Hospitalier Universitaire de Liège - CHU > > Cardiologie >]
Legrand, Victor mailto [Centre Hospitalier Universitaire de Liège - CHU > > Cardiologie >]
International Journal of Cardiology
Yes (verified by ORBi)
The Netherlands
[en] Adult ; Aged ; Analysis of Variance ; Angina Pectoris/blood/therapy ; Angina, Unstable/blood/therapy ; Angioplasty, Transluminal, Percutaneous Coronary ; Biological Markers/blood ; Blood Vessel Prosthesis Implantation ; C-Reactive Protein/metabolism ; Cytokines/blood ; Female ; Humans ; Lactoferrin/blood ; Male ; Middle Aged ; Neutrophil Activation ; Pancreatic Elastase/blood ; Peroxidase/blood ; Stents ; Time Factors ; Treatment Outcome
[en] BACKGROUND: Polymorphonuclear neutrophils have been implicated in the pathophysiology of atherosclerosis. A substantial body of evidence has emerged to implicate the role of specific leucocyte derived enzyme myeloperoxidase in atherogenesis, since its initiation through progression until destabilization. The aim of the study was to determine the presence of polymorphonuclear neutrophils activation after coronary stenting, to compare this activation between stable and unstable setting and to evaluate the kinetic relation of this activation with inflammatory response following atherosclerotic plaque rupture. METHODS: Myeloperoxidase, lactoferrin, elastase, C-reactive protein and cytokine plasma levels were assessed in 15 patients undergoing direct coronary stenting for unstable angina (Group A) and compared to 11 patients undergoing this procedure for stable angina (Group B). Serial sampling starting before arteriography and continued for 24 h was carried out in all patients. RESULTS: A significant elevation in myeloperoxidase and lactoferrin levels was observed after stenting in both group A (p<0.0001) and group B (p<0.0001), but was higher in group A. Interleukin-8, interleukin-12 and interleukin-6 levels increased temporarily after stenting in the 2 groups. Baseline values of C-reactive protein were similar in the 2 groups and a progressive increase was observed after the intervention. CONCLUSIONS: Direct coronary artery stenting is associated with an early polymorphonuclear neutrophils activation followed by release of inflammatory cytokines (interleukin-6, interleukin-8, interleukin-12) and C-reactive protein elevation in both stable and unstable patients. We conclude that stenting by itself is associated with myeloperoxidase liberation with a significantly enhanced response in unstable patients.

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