Article (Scientific journals)
Les criteres de jugement dans les essais cliniques: reflexions a propos d'etudes recentes de prevention cardio-vasculaire.
Scheen, André
2006In Revue Médicale de Liège, 61 (4), p. 260-6
Peer reviewed
 

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Keywords :
Cardiovascular Diseases/prevention & control; Clinical Trials as Topic; Evidence-Based Medicine; Humans; Risk Factors
Abstract :
[en] The comparison of two therapeutic interventions requires the use of endpoints in randomized clinical trials, which supports evidence-based medicine. It is preferable to consider hard endpoints, such as major clinical events and mortality rather than biological or surrogate endpoints. In large cardiovascular prevention trials, it is now well accepted to analyze primary and secondary endpoints as well as to use combined clinical endpoints. Such composite endpoints offer the advantage of increasing the number of events, but have the disadvantage of diluting the therapeutic effect and of exposing to possible bias. We discuss this crucial issue at the light of controversial results from a few recent important cardiovascular prevention trials.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Language :
French
Title :
Les criteres de jugement dans les essais cliniques: reflexions a propos d'etudes recentes de prevention cardio-vasculaire.
Alternative titles :
[en] How I explore...outcomes in clinical trials: comments about recent studies of cardiovascular prevention
Publication date :
2006
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Volume :
61
Issue :
4
Pages :
260-6
Peer reviewed :
Peer reviewed
Additional URL :
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