Reference : Thymopoietin and thymopentin enhance the levels of ACTH, beta-endorphin and beta-lipo...
Scientific journals : Article
Human health sciences : Rheumatology
Thymopoietin and thymopentin enhance the levels of ACTH, beta-endorphin and beta-lipotropin from rat pituitary cells in vitro
Malaise, Michel mailto [Université de Liège - ULiège > Département des sciences cliniques > Rhumatologie >]
Hazee-Hagelstein, Marie-Thérèse mailto [Université de Liège - ULiège > > Endocrinologie clinique >]
Reuter, A. M. [ > > ]
Vrinds-Gevaert, Y. [ > > ]
Goldstein, G. [ > > ]
Franchimont, P. [ > > ]
Acta Endocrinologica
Yes (verified by ORBi)
[en] Endorphins ; Peptide Fragments ; Thymopoietins ; Thymus Hormones
[en] Thymopoietin and thymopentin are well characterized polypeptides influencing
immunoregulation by several mechanisms. Proposed as a therapy in diseases with
major immune abnormalities such as rheumatoid arthritis, thymopentin improved
within 2 weeks some clinical parameters as pain and joint swelling. The
hypothesis that this spectacular effect could be mediated through interactions
with anti-inflammatory (ACTH) and pain relieving (beta-endorphin) hormones
producing cells was tested on the rat isolated pituitary cell model. Thymopentin
and thymopoietin can enhance in vitro the levels of ACTH, beta-endorphin and
beta-lipotropin in a time- and dose-dependent fashion for physiological
concentrations ranging from 10(-12) to 10(-8) mol/l. The action on pituitary
cells was restricted to those molecules as no changes occurred in LH, FSH, GH,
TSH and PRL levels, after otherwise identical experimental conditions.
Researchers ; Professionals

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