Thymopoietin and thymopentin enhance the levels of ACTH, beta-endorphin and beta-lipotropin from rat pituitary cells in vitro

Malaise, Michel; Hazee-Hagelstein, Marie-Thérèse; Reuter, A. M.; Vrinds-Gevaert, Y.; Goldstein, G.; Franchimont, P.

Reference : Thymopoietin and thymopentin enhance the levels of ACTH, beta-endorphin and beta-lipo...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Rheumatology
	To cite this reference:	http://hdl.handle.net/2268/94616

Title :	Thymopoietin and thymopentin enhance the levels of ACTH, beta-endorphin and beta-lipotropin from rat pituitary cells in vitro
Language :	English
Author, co-author :	Malaise, Michel [Université de Liège - ULiège > Département des sciences cliniques > Rhumatologie >]
	Hazee-Hagelstein, Marie-Thérèse [Université de Liège - ULiège > > Endocrinologie clinique >]
	Reuter, A. M. [ > > ]
	Vrinds-Gevaert, Y. [ > > ]
	Goldstein, G. [ > > ]
	Franchimont, P. [ > > ]
Publication date :	1987
Journal title :	Acta Endocrinologica
Publisher :	Periodica
Volume :	115
Issue/season :	4
Pages :	455-460
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0001-5598
City :	Copenhagen
Country :	Denmark
Keywords :	[en] Endorphins ; Peptide Fragments ; Thymopoietins ; Thymus Hormones
Abstract :	[en] Thymopoietin and thymopentin are well characterized polypeptides influencing immunoregulation by several mechanisms. Proposed as a therapy in diseases with major immune abnormalities such as rheumatoid arthritis, thymopentin improved within 2 weeks some clinical parameters as pain and joint swelling. The hypothesis that this spectacular effect could be mediated through interactions with anti-inflammatory (ACTH) and pain relieving (beta-endorphin) hormones producing cells was tested on the rat isolated pituitary cell model. Thymopentin and thymopoietin can enhance in vitro the levels of ACTH, beta-endorphin and beta-lipotropin in a time- and dose-dependent fashion for physiological concentrations ranging from 10(-12) to 10(-8) mol/l. The action on pituitary cells was restricted to those molecules as no changes occurred in LH, FSH, GH, TSH and PRL levels, after otherwise identical experimental conditions.
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/94616

File(s) associated to this reference

Fulltext file(s):

	File	Commentary	Version	Size	Access
Restricted access	Malaise_1987_ActaEndocrinologica_455-460.pdf		Publisher postprint	343.33 kB	Request copy

All documents in ORBi are protected by a user license.

Dspace v1.5