Reference : Thymopoietin and thymopentin enhance the levels of ACTH, beta-endorphin and beta-lipo... |
Scientific journals : Article | |||
Human health sciences : Rheumatology | |||
http://hdl.handle.net/2268/94616 | |||
Thymopoietin and thymopentin enhance the levels of ACTH, beta-endorphin and beta-lipotropin from rat pituitary cells in vitro | |
English | |
Malaise, Michel ![]() | |
Hazee-Hagelstein, Marie-Thérèse ![]() | |
Reuter, A. M. [ > > ] | |
Vrinds-Gevaert, Y. [ > > ] | |
Goldstein, G. [ > > ] | |
Franchimont, P. [ > > ] | |
1987 | |
Acta Endocrinologica | |
Periodica | |
115 | |
4 | |
455-460 | |
Yes (verified by ORBi) | |
International | |
0001-5598 | |
Copenhagen | |
Denmark | |
[en] Endorphins ; Peptide Fragments ; Thymopoietins ; Thymus Hormones | |
[en] Thymopoietin and thymopentin are well characterized polypeptides influencing
immunoregulation by several mechanisms. Proposed as a therapy in diseases with major immune abnormalities such as rheumatoid arthritis, thymopentin improved within 2 weeks some clinical parameters as pain and joint swelling. The hypothesis that this spectacular effect could be mediated through interactions with anti-inflammatory (ACTH) and pain relieving (beta-endorphin) hormones producing cells was tested on the rat isolated pituitary cell model. Thymopentin and thymopoietin can enhance in vitro the levels of ACTH, beta-endorphin and beta-lipotropin in a time- and dose-dependent fashion for physiological concentrations ranging from 10(-12) to 10(-8) mol/l. The action on pituitary cells was restricted to those molecules as no changes occurred in LH, FSH, GH, TSH and PRL levels, after otherwise identical experimental conditions. | |
Researchers ; Professionals | |
http://hdl.handle.net/2268/94616 |
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