Evidence that the phagocytosis mediated by the peanut agglutinin-like activity of IgG(Fc) receptors of human monocytes is selectively modulated by estradiol and natural estrogens
Malaise, Michel; Franchimont, P.; Mahieu, P. R.
1988 • In Journal of Clinical Immunology, 8 (6), p. 495-502
[en] The percentage of human monocytes (MCs) that are able to form rosettes with, and
to phagocytose, IgG-coated sheep red blood cells (IgG-SRBCs) has been first
determined in vitro by a classical rosette assay in 12 postmenopausal (PM) women.
Half of them never received any suppletive estrogen (E) therapy at the time of
testing, whereas the other six were chronically treated with E. Three different
preparations of the same anti-SRBC IgG antibody batch were coated to SRBCs: the
first one was the starting antibody preparation [IgG(total] and the other two
were purified by affinity chromatography either on Sepharose-concanavalin A (Con
A) or on agarose-peanut agglutinin (PNA) columns specifically recognizing
terminal, and/or accessible, alpha-mannosyl [IgG(Con A)] or beta-galactosyl
[IgG(PNA)] residues of the Fc domain, respectively. The three IgG preparations
exhibited similar hemagglutinating antibody titers (1/100). All experiments were
conducted using a coating range of 5000 to 6000 IgG antibody molecules per SRBC.
In PM women with E, the rosetting capacity of autologous MCs (percentage of MCs
rosetting at least three IgG-SRBCs), their phagocytosing capacity (percentage of
MCs ingesting at least three IgG-SRBCs), and the phagocytosis index (number of
SRBCs ingested/100 MCs) were similar for each IgG-SRBC preparation considered. In
contrast, in PM women without E, the capacity of MCs to phagocytose
IgG(PNA)-SRBCs, as well as the phagocytosis index measured with those SRBCs, was
strongly reduced (P less than 0.01 at least), when compared to the same
parameters determined using IgG(total)-SRBCs and IgG(Con A)-SRBCs.
Disciplines :
Rheumatology
Author, co-author :
Malaise, Michel ; Université de Liège - ULiège > Département des sciences cliniques > Rhumatologie
Franchimont, P.
Mahieu, P. R.
Language :
English
Title :
Evidence that the phagocytosis mediated by the peanut agglutinin-like activity of IgG(Fc) receptors of human monocytes is selectively modulated by estradiol and natural estrogens
Publication date :
1988
Journal title :
Journal of Clinical Immunology
ISSN :
0271-9142
eISSN :
1573-2592
Publisher :
Kluwer Academic/Plenum Publishers, New York, United States - New York
Lobuglio A.F., Cotran R.S., Jandl J.H. (1967) Red cells with immunoglobulin G: Binding and sphering by mononuclear cells in man. Science 158:1582-1584.
Ciccimarra F., Rosen F.S., Merler E. (1975) Localization of the IgG effector site for monocyte receptors. Proc Natl Acad Sci USA 72:2081-2083.
Huber H., Douglas S.D., Fudenberg H.H. (1969) The IgG receptor: An immunological marker for the characterization of mononuclear cells. Immunology 17:7-20.
Malaise M.G., Franchimont P., Gomez F., Bouillenne C., Mahieu P.R. (1987) The spontaneous ability of normal human IgG to inhibit the Fc receptors of normal human monocytes is related to their binding capacity to lectins. Clin Immunol Immunopathol 45:1-16.
Ross G.D., Cain J.A., Lachmann P.J. (1985) Membrane complement receptor type three (CR3) has lectin-like properties analogous to bovine conglutinin and functions as a receptor for zymosan and rabbit erythrocytes as well as a receptor for iC3b. J Immunol 134:3307-3315.
Fries L.F., Brickman C.M., Frank M.M. (1983) Monocyte receptors for the Fc portion of IgG increase in number in autoimmune hemolytic anemia and other hemolytic states and are decreased by glucocorticoid therapy. J Immunol 131:1240-1245.
Schreiber A.D., Chien P., Tomaski A., Cines D.B. (1987) Effect of danazol in immune thrombocytopenia purpura. N Engl J Med 316:503-508.
Friedman D., Nettl F., Schreiber A.D. (1985) Effect of estradiol and steroid analogues on the clearance of immunoglobulin G-coated erythrocytes. J Clin Invest 75:162-167.
Scheidegger J.J. (1955) Une microméthode de l'immunoélectrophorèse. Int Arch Allergy Appl Immunol 7:103-110.
Laemmli U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
Malaise M.G., Foidart J.B., Hauwaert C., Mahieu P., Franchimont P. (1985) In vivo studies on the mononuclear phagocyte system Fc receptor function in rheumatoid arthritis. Correlations with clinical and immunological variables. J Rheumatol 12:33-42.
Ekins R.P. (1974) Radioimmunoassay and saturation analysis. Br Med Bull 30:3-11.
Malaise M.G., Franchimont P., Houssier C., Closset J., Hennen G., Mahieu P.R. (1986) In vitro studies on the Fc-receptor function of mononuclear phagocytes in rheumatoid arthritis: Relation between the Fc-receptor blockade and the concanavalin A-binding capacity of autologous immunoglobulin G. J Clin Immunol 6:442-456.
Hoyoux C., Foidart J.B., Rigo P., Mahieu P., Geubelle F. (1984) Effect of methylprednisolone on the Fc-receptor function of human reticuloendothelial system in vivo. Eur J Clin Invest 14:60-66.
Kurlander R.J. (1980) Reversible and irreversible loss of Fc-receptor function of human monocytes as a consequence of interaction with immunoglobulin G. J Clin Invest 66:773-781.
Abraon N., Gelfand E.W., Jandl J.H., Rosen F.S. (1970) The interaction between human monocytes and red cells. Specificity for IgG subclasses and IgG fragments. J Exp Med 132:1207-1215.
van Loghem J.J., van der Meulen E.W., Fleer A., van der Hart M.I., von dem Borne A.E., Engelfriet C.P. The importance of Fc receptor for red cell destruction under the influence of noncomplement binding antibodies in human blood groups. 5th International Convocation of Immunology , Karger AG, Buffalo, NY, Basel; 1977, 75-84.
Sivam G., Cohen, Dodd R.C., Gray T.K. (1987) 17β-Estradiol inhibits the oxydative metabolism of U937 cells indirectly via lymphocytes. Endocrinology 121:853-857.
Stanworth D.R., Turner M.W. (1986) Immunochemical analysis of human and rabbit immunoglobulins and their subunits. Handbook of Experimental Immunology: Immunochemistry, Vol 1 , D.M., Weir, Blackwell Scientific, Oxford; 1-46.
Parekh R.B., Dwek R.A., Sutton B.J., Fernandes D.L., Leung A., Stanworth D., Rademacher T.W., Mizuochi T., Taniguchi T., Matsuta K., Takeuchi F., Nagano Y., Miyamoto T., Kobata A. (1985) Association of rheumatoid arthritis and primary osteoarthritis with changes in the glycosylation pattern of total serum IgG. Nature 316:452-457.
.
Willia R.C., Osterland C.K., Margherita S., Tokuda S., Messner R.P. (1973) Studies of biologic and serologic activities of rabbit-IgG antibody depleted of carbohydrate residues. J Immunol 111:1690-1698.
Koide N., Nose M., Muramatsu T. (1977) Recognition of IgG by Fc receptor and complement: Effects of glycosidase digestion. Biochem Biophys Res Commun 75:838-844.
Nose M., Wigzell H. (1983) Biological significance of carbohydrate chains on monoclonal antibodies. Proc Natl Acad Sci USA 80:6632-6636.
Miyazaki J.I., Appella E., Zhao H., Forman J., Ozato K. (1986) Expression and function of a nonglycosylated major histocompatibility class I antigen. J Exp Med 163:856-871.
Cronin M.E. (1985) Rheumatic aspects of endocrinopathies. Arthritis and Allied Conditions , D.J., McCarty, Lea & Febiger, Philadelphia; 1607-1623.