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Article (Scientific journals)

Interleukin-6: An osteotropic factor influencing bone formation?

Franchimont, N.; Wertz, Sylvie; Malaise, Michel

2005 • In BONE, 37 (5), p. 601-606

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https://hdl.handle.net/2268/94562

DOI
10.1016/j.bone.2005.06.002

PubMed
16112634

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Keywords :

interleukin-6; Bone formation; Bone Resorption/physiopathology; Cell Differentiation; Cell Proliferation; Humans; Interleukin-6/physiology; Leptin/physiology; Osteoblasts/cytology/pathology/physiology; Osteogenesis/physiology; Receptors, Interleukin-6/physiology; Signal Transduction

Abstract :

[en] Interleukin (IL)-6 has long been considered as an osteoresorptive factor. However, recent data indicate that IL-6 could influence bone formation in conditions of increased bone turnover. In this paper, the effects of IL-6 and its soluble receptor on osteoblast proliferation, differentiation and apoptosis are readdressed. A brief summary of IL-6 signaling after binding to its receptor is provided and hypotheses concerning IL-6 and the central control of bone formation are also highlighted. (c) 2005 Elsevier Inc. All rights reserved.

Disciplines :

Endocrinology, metabolism & nutrition

Author, co-author :

Franchimont, N.

Wertz, Sylvie ; Université de Liège - ULiège > Gastro-Entérologie-Hépatologie

Malaise, Michel ; Université de Liège - ULiège > Département des sciences cliniques > Rhumatologie

Language :

English

Title :

Interleukin-6: An osteotropic factor influencing bone formation?

Publication date :

November 2005

Journal title :

BONE

ISSN :

8756-3282

eISSN :

1873-2763

Publisher :

Elsevier Science, New York, United States - New York

Volume :

37

Issue :

5

Pages :

601-606

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 29 June 2011

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Scopus citations^®

164

Scopus citations^®
without self-citations

163

OpenCitations

141

OpenAlex citations

183

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