Reference : Interleukin-6: An osteotropic factor influencing bone formation?
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
http://hdl.handle.net/2268/94562
Interleukin-6: An osteotropic factor influencing bone formation?
English
Franchimont, N. [> > > >]
Wertz, Sylvie mailto [Université de Liège - ULiège > > Gastro-Entérologie-Hépatologie >]
Malaise, Michel mailto [Université de Liège - ULiège > Département des sciences cliniques > Rhumatologie]
Nov-2005
BONE
Elsevier Science
37
5
601-606
Yes (verified by ORBi)
International
8756-3282
1873-2763
New York
NY
[en] interleukin-6 ; Bone formation ; Bone Resorption/physiopathology ; Cell Differentiation ; Cell Proliferation ; Humans ; Interleukin-6/physiology ; Leptin/physiology ; Osteoblasts/cytology/pathology/physiology ; Osteogenesis/physiology ; Receptors, Interleukin-6/physiology ; Signal Transduction
[en] Interleukin (IL)-6 has long been considered as an osteoresorptive factor. However, recent data indicate that IL-6 could influence bone formation in conditions of increased bone turnover. In this paper, the effects of IL-6 and its soluble receptor on osteoblast proliferation, differentiation and apoptosis are readdressed. A brief summary of IL-6 signaling after binding to its receptor is provided and hypotheses concerning IL-6 and the central control of bone formation are also highlighted. (c) 2005 Elsevier Inc. All rights reserved.
Researchers ; Professionals
http://hdl.handle.net/2268/94562
10.1016/j.bone.2005.06.002

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