Reference : Immune response and antigen recognition in non-pregnant ewes experimentally infected ...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
Immune response and antigen recognition in non-pregnant ewes experimentally infected with Neospora caninum tachyzoites.
Rettigner, Chantal [Université de Liège - ULiège > Faculté de Médecine Vétérinaire > > >]
Lasri, Saadia [> > > >]
De Meerschman, Francois [> > > >]
Focant, Charles mailto [Université de Liège - ULiège > Département des sciences de la vie > Biologie et génétique moléculaire >]
Beckers, Jean-François mailto [Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie de la reproduction >]
Losson, Bertrand mailto [Université de Liège - ULiège > Département des maladies infectieuses et parasitaires > Parasitologie et pathologie des maladies parasitaires >]
Veterinary Parasitology
Yes (verified by ORBi)
The Netherlands
[en] Acute Disease ; Animals ; Antibodies, Protozoan/biosynthesis/blood ; Antigen-Antibody Reactions ; Antigens, Protozoan/diagnostic use/immunology ; Blotting, Western/veterinary ; Coccidiosis/diagnosis/immunology/veterinary ; Female ; Immunity, Cellular ; Immunoglobulin G/biosynthesis/blood ; Immunoglobulin M/biosynthesis/blood ; Lymphocyte Activation ; Molecular Weight ; Neospora/immunology ; Sheep ; Sheep Diseases/diagnosis/immunology
[en] The cellular and humoral responses as well as the antigen recognition during the acute stage of a Neospora caninum (NC) infection were investigated in non-pregnant ewes. The experimentally infected ewes developed specific lymphoproliferative and humoral responses within 2 weeks post-infection (PI). The magnitude of the cellular response showed large variations between animals. A significant decrease in the proliferative response to Con A mitogen and N. caninum, Toxoplasma gondii (TG) antigens was recorded on day 21 post-infection (PI). The humoral response and the pattern of antigen recognition were similar among infected ewes. Proteins of 44, 42, 40, 39 and 28 kDa were intensively recognized by the infected animals during the experiment. The 42 and 28 kDa antigens should be considered as useful for the diagnostic of N. caninum infection, as the intensity of recognition infection of the other antigens had decreased markedly 8 weeks post-infection. For some antigens a sequential recognition was recorded. The 59, 54 and 38-37 kDa proteins were frequently recognized by infected sera during the first weeks of the infection, but recognition of these antigens was absent or rare at the end of the experiment. These antigens could be related to the acute stage of the infection.
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