Diagnosis and monitoring of pregnancy in sheep: reality and perspectives

El Amiri, Bouchra; Karen, Aly; Cognié, Yves; Melo de Sousa, Noelita; Hornick, Jean-Luc; Szenci, Otto; Beckers, Jean-François

Request a copy

Article (Scientific journals)

Diagnosis and monitoring of pregnancy in sheep: reality and perspectives

El Amiri, Bouchra; Karen, Aly; Cognié, Yves et al.

2003 • In Productions Animales, 16 (2), p. 79-90

Peer Reviewed verified by ORBi

Permalink
https://hdl.handle.net/2268/9289

Files (1)Send to Details Statistics Bibliography Similar publications

Files

Full Text

ElAmiriB_ProdAnim_2003.pdf

Publisher postprint (292.52 kB)

Request a copy

All documents in ORBi are protected by a user license.

Send to

RIS BibTex APA Chicago Permalink X Linkedin

Details

Keywords :

diagnosis; sheep; pregnancy

Abstract :

[en] The present review aims at presenting different methods for pregnancy diagnosis. Since these methods are to be used in the herds, precocity, sensitivity, specificity, accuracy to predict pregnant and non-pregnant ewes, and the possibility to determine fetal numbers are carefully analysed. The progesterone assay is accurate as early as day 17th after fecundation; but the fertilization day must be precisely known. The pregnancy specific or associated glycoproteins (PSPB/PAG) assay is highly sensitive and specific at day 22 in blood and at day 32 in milk samples. However, this assay does not allow to predict the fetal number. The ultrasonography B-mode used on 30 days of gestation gives very good or excellent performance in terms of sensitivity and specificity depending on the practitioner. The method is also able to predict the real time fetal number.
[fr] Cet article décrit les différentes méthodes cliniques et de laboratoire utilisables pour établir le diagnostic de la gestation chez les ovins. Etant destinées à des applications dans les élevages, ces méthodes sont présentées en insistant sur la précocité de leur utilisation, sur les paramètres de sensibilité, de spécificité, d'exactitude de diagnostic positif, d'exactitude de diagnostic négatif et enfin sur leurs possibilités de dénombrement des foetus. La méthode la plus précoce est le dosage de la progestérone. Elle fournit dès le 17e jour des valeurs élevées d'exactitude mais nécessite de connaître exactement le moment de la fécondation. Le dosage des protéines spécifiques ou associées à la gestation (PSPB, PAG) est également une méthode précoce, le diagnostic étant obtenu dès le 22e jour pour un dosage dans le sang et le 32e jour pour un dosage dans le lait. Il présente d'excellentes performances de sensibilité et de spécificité, mais ne permet pas de dénombrer les foetus. Enfin, l'échographie mode-B, utilisable dès le 30e jour de gestation, donne, selon l'opérateur, de très bonnes à d'excellentes performances de sensibilité et de spécificité et permet de dénombrer les foetus en temps réel

Disciplines :

Veterinary medicine & animal health

Author, co-author :

El Amiri, Bouchra; Université de Liège - ULiège > Faculté de médecine vétérinaire

Karen, Aly

Cognié, Yves

Melo de Sousa, Noelita ; Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie de la reproduction

Hornick, Jean-Luc ; Université de Liège - ULiège > Département de productions animales > Nutrition des animaux domestiques

Szenci, Otto

Beckers, Jean-François ; Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie de la reproduction

Language :

French

Title :

Diagnosis and monitoring of pregnancy in sheep: reality and perspectives

Alternative titles :

[fr] Diagnostic et suivi de gestation chez la brebis : réalités et perspectives

Publication date :

2003

Journal title :

Productions Animales

ISSN :

0990-0632

eISSN :

1152-5428

Publisher :

Inst Natl Recherche Agronomique, Paris Cedex 07, France

Volume :

Issue :

Pages :

79-90

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 19 March 2009

Statistics

Number of views

281 (1 by ULiège)

Number of downloads

2 (0 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

Bibliography

Aiumlamai S., Fredriksson G., Nilsfors L., 1992. Real-time ultrasonography for determining the gestational age of ewes. Vet. Rec., 131, 560-562.
Borjesson D.L., Boyce W.M., Gardner I.A., Deforge J., Lasley B., 1996. Pregnancy detection in Bighorn sheep (Ovis canadensis) using a fecal-based enzyme immunoassay. J. Wildl. Dis., 32, 67-74.
Bosc M.J., 1971. Etude d'un diagnostic de gestation par ultrasons et effet Doppler chez la brebis. Ann. Zootech., 20, 107-110.
Bretzlaff K., Edwards J., Forrest D., Nuti L., 1993. Ultrasonographic determination of pregnancy in small ruminants. Vet. Med., 88, 12-24.
Buckrell B.C., Bonnett B.N., Johnson W.H., 1986. The use of real-time ultrasound rectally for early pregnancy diagnosis in sheep. Theriogenology, 25, 665-673.
Butler J.E., Hamilton W.C., Sasser R.G., Ruder C.A., Hass G.M., Williams R.R., 1982. Detection and partial characterization of two bovine pregnancy-specific proteins. Biol. Reprod., 26, 925-933.
Butler W.R., Fullenkamp S.M., Cappiello L.A., Handwerger S., 1981. The relationship between breed and litter size in sheep and maternal serum concentrations of placental lactogen, estradiol and progesterone. J. Anim. Sci., 53, 1077-1081.
Chan J.S., Robertson H.A., Friesen H.G., 1976. The purification and characterization of ovine placental lactogen. Endocrinology, 98, 65-76.
Chan J.S.D., Robertson H.A., Friesen H.G., 1978. Maternal and fetal concentration of ovine placental lactogen measured by RIA. Endocrinology, 102, 1606-1613.
Chan J.S., Nie Z.R., Seidah N.G., Chretien M., 1986. Purification of ovine placental lactogen (oPL) using high-performance liquid chromatography. Evidence for two forms of oPL. FEBS Lett., 199, 259-264.
Chauhan F.S., Waziri M.A., 1991. Evaluation of rectal-abdominal palpation technique and hormonal diagnosis of pregnancy in small ruminant. Indian J. Anim. Reprod., 12, 63-67.
Colosi P., Thordarson G., Hellmiss R., Singh K., Forsyth I.A., Gluckman P., Wood W.I., 1989. Cloning and expression of ovine placental lactogen. Mol. Endocrinol., 3, 1462-1469.
Cunningham N.F., Symons A.M., Saba N., 1975. Levels of progesterone, LH and FSH in the plasma of sheep during the oestrous cycle. J. Reprod. Fertil., 45, 177-180.
Davey C.G., 1986. An evaluation of pregnancy testing in sheep using a real-time ultrasound scanner. Aust. Vet. J., 63, 347-348.
Deas D.W., 1977. Pregnancy diagnosis in the ewe by an ultrasonic rectal probe. Vet. Rec., 101, 113-115.
Delalhaut P., Beckers J.F., Ectors F., 1979. Effet de l'azide de sodium sur la dégradation de la progestérone dans des échantillons de sang total chez les bovines. Ann. Méd. Vét., 123, 567-572.
Derivaux J., Ectors F., 1980. Physiopathologie de la gestation et obstétrique vétérinaire. Les Editions du Point Vétérinaire, Maisons-Alfort, France, 31-45.
Dobson H., Davies D., Ward W.R., Winter A.C., Humblot P., 1993. Pregnancy specific protein B, oestrone sulphate and echography as possible indices of embryonic death and fetal number in prolific ewes. J. Reprod. Fertil., 12 (abstr), 29.
Doize F., Vaillancourt D., Carabin H., Belanger D., 1997. Determination of gestational age in sheep and goats using transrectal ultrasonographic measurement of placentomes. Theriogenology, 48, 449-460.
Dwyer R.J., Robertson H.A., 1980. Oestrogen sulphatase and sulphotransferase activities in the endometrium of the sow and ewe during pregnancy. J. Reprod. Fertil., 60,187-191.
El Amiri B., Remy B., Sousa N.M., Joris B., Ottiers N.G., Perenyi Z., Mboko H.B., Beckers J.F., 2003. Isolation and partial characterization of three pregnancy-associated glycoproteins from the ewe placenta. Mol. Reprod. Dev., 64, 199-206.
Ford E.J.H., Clark J.W., Gallup A.L., 1963. The detection of fetal numbers in sheep by means of X-rays. Vet. Rec., 75, 958-960.
Fowler D.G., Wilkins J.F., 1984. Diagnosis of pregnancy and number of the fetuses in sheep by real-time ultrasonic imaging. 1. Effect of number of fetuses, stage of gestation, operator and breed of ewe on accuracy of diagnosis. Livest. Prod. Sci., 11, 437-450.
Fraser A.F., Nagaratnam V., Calli-Cott R.B., 1970. A correlation between heart rate and age in the sheep fœtus and its use in predicting the birth date. Trop. Anim. Health and Prod., 2, 65.
Gajewski Z., Beckers J.F., Melo De Sousa N., Thun R., Sulon J., 1999. Determination of pregnancy associated glycoprotein concentrations in sheep: A retrospective study. Advances Cell Biol., 26 (Suppl. 12), 89-96.
Garcia A., Neary M.K., Kelly G.R., Pierson R.A., 1993. Accuracy of ultrasonography in early pregnancy diagnosis in the ewe. Theriogenology, 39, 847-861.
Gearhart M.A, Wingfield W.E., Knight A.P., Smith J.A., Dargatz D.A., Boon J.A., Stokes C.A., 1988. Real-time ultrasonography for determining pregnancy status and viable fetal numbers in ewes. Theriogenology, 30, 323-337.
Gogolin-Ewens K.J., Lee C.S., Mercer W.R., Moseby A.M., Brandon M.R., 1986. Characterization of a sheep trophoblast-derived antigen first appearing at implantation. Placenta, 7, 243-255.
González B.A., Santiago M.J., Lopez S.A., 1998. Estimation of fetal development in Manchega dairy ewes by transrectal ultrasonographic measurements. Small Rumin. Res., 27, 243-250.
Grace N.D., Beach A.D., Quinlivan T.D., Ward B., 1989. Multiple pregnancy diagnosis of using real time ultrasonic body scanner and video-fluoroscopy systems. Proc. N.Z. Soc. Anim. Prod., 49, 107-111.
Haibel G.K., Perkins N.R., 1989. Real-time ultrasonic biparietal diameter of second trimester Suffolk and Finn sheep fetuses and prediction of gestational age. Theriogenology, 32, 863-869.
Hulet C.V., 1972. A rectal-abdominal palpation technique for diagnosing pregnancy in the ewe. J. Anim. Sci., 35, 814-818.
Hulet C.V., 1973. Determining fetal numbers in pregnant ewes. J. Anim. Sci., 36, 325-330.
Illera J.C., Gracia O., Silvan G., Illera M.J., Munro C.J., Illera M., 2000. Assessment of fetal number and fetal viability throughout pregnancy in Manchega ewe. Proc. 14th Intl Cong. Anim. Reprod., Stockholm, 2, 181.
Jardon C., 1988. Utilisation actuelle du diagnostic de gestation, en élevage, chez la brebis. Rec. Méd. Vét., 164, 135-140.
Jardon C., De Montigny G., Andre D., Corteel J.M., Baril G., Cognié Y., Botero-Herrera O., Humblot P., 1984. Les méthodes de diagnostic de gestation applicables aux ovins et aux caprins. IXe Journées Rech. ovine et caprine, Inra-Itovic, Paris, 452-473.
Kalkan C., Cetin H., Kaygusuzoglu E., Yilmaz B., Ciftci M., Yidiz H., Yildiz A., Deveci H., Apaydin A.M., Ocal H., 1996. An investigation on plasma progesterone levels during pregnancy and parturition in the Ivesi sheep. Acta. Vet. Hung., 44, 335-340.
Karen A., Kovács P., Beckers J.F., Szenci O., 2001. Review article pregnancy diagnosis in sheep: review of the most practical methods. Acta. Vet. Brno, 70, 115-126.
Karen A., Beckers J.F., Sulon J., Sousa N.M., Szabados, K., Reczigel J., Szenci O., 2003. Early pregnancy diagnosis in sheep by progesterone and pregnancy-associated glyco-protein tests. Theriogenology, 59, 1941-1948.
Kelly R.W., Newnham J.P., 1989. Estimation of gestational age in Merino ewes by ultrasound measurement of fetal head size. Aust. J. Agric. Res., 40, 1293-1299.
Laplanche, A., Com-Nougue, C., Flamant, R., 1987. Méthodes de statistiques appliquées à la recherche clinique. Ed. Flamarion Méd. Sci., Paris.
Levy I., Emew P., Mialot JP., 1990. Echographie et gestion des troupeaux ovins. Rec.Méd. Vét., 166, 751-764.
Lindahl I.L., 1971. Pregnancy diagnosis in the ewe by intrarectal Doppler. J. Anim. Sci., 32, 922-925.
Linzell J.L., Heap R.B., 1968. A comparison of progesterone metabolism in the pregnant sheep and goat: sources of production and an estimation of uptake by some target organs. J. Endocrinol., 41, 433-438.
Logue N.D., Hall J.T., McRoberts S., Waterhouse H., 1987. Real-time ultrasonic scanning in sheep: The results of first year of its application on farms in south-west Scotland. Vet. Rec., 121, 146-149.
Mac Farlane J.S., 1973. Diagnosis pregnancy. Vet Rec., 93, 270.
Madel A.J., 1983. Detection of pregnancy in ewe lambs by A-mode ultrasound. Vet. Rec., 112, 11-12.
Martal J., Djiane J., 1975. Purification of a lactogenic hormone in sheep placenta. Biochem. Biophys. Res. Commun., 65, 770-778.
Martal J., Djiane J., Dubois M.P., 1977. Immunofluorescent localization of ovine placental lactogen. Cell Tissue Res., 184, 427-433.
Meredith M.J., Madani M.O.K., 1980. The detection of pregnancy in sheep by A-mode ultrasound. Br. Vet. J., 136, 325-330.
Mialot J.P, Levy I., Grimard B., 1991. L'échographie dans la gestion de la reproduction chez les bovins. Rec. Méd. Vét., 167, 21-31.
Morgan L., 1973. Pregnancy detection in ewes. A new tecnic. N.Z. J. Agric., 126, 15-17.
Ranilla M.J., Sulon J., Carro M.D., Mantecon A.R., Beckers J.F., 1994. Plasmatic profiles of pregnancy-associated glycoprotein and progesterone levels during gestation in Churra and Merino sheep. Theriogenology, 42, 537-545.
Ranilla M.J., Sulon J., Mantecon A.R., Beckers J.F., Carro A.D., 1997. Plasma pregnancy- associated glycoprotein and progesterone concentrations in pregnant Assaf ewes carrying single and twin lambs. Small Rumin. Res., 24, 125-131.
Robertson H.A., Chan J.S.D., Riesen H.G., 1980. The use of a pregnancy-specific antigen, chorionic somatomammotrophin, as an indicator of pregnancy in sheep. J. Reprod. Fert., 58, 279-281.
Royal L., Tainturier D., 1976. Mise au point sur les procédés modernes de diagnostic de gestation chez la brebis. Rev. Méd. Vét., 127, 1009-1034.
Russel A.J.F., Goddard P.J., 1995. Small ruminant reproductive ultrasonography. In: Goddard P.G. ed), Veterinary ultrasonography, 257-274. CAB International, Wallingford, UK.
Schrick F.N., Inskeep E.K., 1993. Determination of early pregnancy in ewes utilizing transrectal ultrasonography. Theriogenology., 40, 295-306.
Sergeev L., Kleemann D.O., Walker S.K., Smith D.H., Grosser T.I., Mann T., Seamark R.F., 1990. Real-time ultrasound imaging for predicting ovine fetal age. Theriogenology, 34, 593-601.
Shemesh M., Ayalon N., Mazor T., 1979. Early pregnancy diagnosis in the ewe, based on milk progesterone levels. J. Reprod. Fertil., 56, 301-304.
Taverne M.A.M., Lavoir M.C., Van Oord R., Van Der Weyden G.C., 1985. Accuracy of pregnancy diagnosis and prediction of fetal numbers in sheep with linear-array real-time ultrasound scanning. The Vet. Quart., 7, 256-263.
Taylor M.J., Jenkin G., Robinson J.S, Thorburn G.D., Friesen H., Chan J.S., 1980. Concentrations of placental lactogen in chronically catheterized ewes and fetuses in late pregnancy. J. Endocrinol., 85, 27-34.
Trapp M.J., Slyter A.L., 1983. Pregnancy diagnosis in the ewe. J. Anim. Sci., 57, 1-5.
Tsang C.P.W., 1978. Plasma levels of œstrone sulfate, free estrogens and progesterone in the pregnant ewe throughout gestation. Theriogenology, 10, 97-110.
Turner C.B., Hindson J.C., 1975. Assessment of a method of manual pregnancy diagnosis in the ewe. Vet. Rec., 96, 56-58.
Tyrrell R.N., Plant J.W., 1979. Rectal damage in ewes following pregnancy diagnosis by rectal-abdominal palpation. J. Anim. Sci., 48, 348-350.
Warren W.C., Liang R., Krivi G.G., Siegel N.R., Anthony R.V., 1990. Purification and structural characterization of ovine placental lactogen. J. Endocrinol., 126, 141-149.
Watt B.R., Andreson G.A., Campell I.P., 1984. A comparison of six methods used for detecting pregnancy in sheep. Aust. Vet. J., 61, 377-382.
Wenham G., Robinson J.J., 1972. Radiographic pregnancy diagnosis in sheep. J. Agric. Sci. (Camb.), 78, 233-238.
White I.R., Russel A.J.F., Fowler D.G., 1984. Real-time ultrasonic scanning in the diagnosis of pregnancy and the determination of fetal numbers in sheep. Vet. Rec., 115, 140-143.
Willard J.M., White D.R., Wesson C.A.R., Stellflug J., Sasser R.G., 1995. Detection of fetal twins in sheep using radioimmunoassay for pregnancy-specific protein B. J. Anim. Sci., 73, 960-966.
Worsfold A.I., Chamings R.J., Booth J.M., 1986. Measurement of œstrone sulfate in sheep as a possible indicator of pregnancy and the number of viable fetuses present. Br. Vet. J., 142, 195-197.
Zoli A.P., Beckers J.F., Ectors F., 1990. Isolation of a ovine pregnancy specific protein. Theriogenology, 33, 366.
Zoli A.P., Beckers J.F., Wouters-Ballman P., Closset J., Falmagne P., Ectors F., 1991. Purification and characterization of a bovine pregnancy-associated glycoprotein. Biol. Reprod., 45, 1-10.
Zoli A.P., Beckers J.F., Ectors F., 1995. Isolement et caractérisation partielle d'une glycoprotéine associée à la gestation chez la brebis. Ann. Méd. Vét., 139, 177-184.