Machine perfusion versus cold storage for preservation of kidneys from expanded criteria donors after brain death

[en] The purpose of this study was to analyze the possible effects of machine perfusion (MP) versus cold storage (CS) on delayed graft function (DGF) and early graft survival in expanded criteria donor kidneys (ECD). As part of the previously reported international randomized controlled trial 91 consecutive heartbeating deceased ECDs – defined according to the United Network of Organ Sharing definition – were included in the study. From each donor one kidney was randomized to MP and the contralateral kidney to CS. All recipients were followed for 1 year. The primary endpoint was DGF. Secondary endpoints included primary nonfunction and graft survival. DGF occurred in 27 patients in the CS group (29.7%) and in 20 patients in the MP group (22%). Using the logistic regression model MP significantly reduced the risk of DGF compared with CS (OR 0.460, P = 0.047). The incidence of nonfunction in the CS group (12%) was four times higher than in the MP group (3%) (P = 0.04). One-year graft survival was significantly higher in machine perfused kidneys compared with cold stored kidneys (92.3% vs. 80.2%, P = 0.02). In the present study, MP preservation clearly reduced the risk of DGF and improved 1-year graft survival and function in ECD kidneys.

Disciplines :

Surgery

Author, co-author :

Treckmann, Jürgen

Moers, Cyril

Smits, Jacqueline M

Gallinat, Anja

Maathuis, Mark-Hugo J

van Kasterop-Kutz, Margitta

Jochmans, Ina

Homan van der Heide, Jaap J

SQUIFFLET, Jean-Paul ; Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation

van Heurn, Ernest

More authors (6 more)

Language :

English

Title :

Machine perfusion versus cold storage for preservation of kidneys from expanded criteria donors after brain death

Publication date :

2011

Journal title :

Transplant International

ISSN :

0934-0874

eISSN :

1432-2277

Publisher :

Springer International, Heidelberg, Germany

Volume :

Pages :

548-554

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 07 June 2011

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Scopus citations^®

189

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144

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171

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213

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