donation; expanded donor pool; kidney; organ pradervation and procurement; outcome
Abstract :
[en] The purpose of this study was to analyze the possible effects of machine perfusion
(MP) versus cold storage (CS) on delayed graft function (DGF) and early
graft survival in expanded criteria donor kidneys (ECD). As part of the previously
reported international randomized controlled trial 91 consecutive heartbeating
deceased ECDs – defined according to the United Network of Organ
Sharing definition – were included in the study. From each donor one kidney
was randomized to MP and the contralateral kidney to CS. All recipients were
followed for 1 year. The primary endpoint was DGF. Secondary endpoints
included primary nonfunction and graft survival. DGF occurred in 27 patients
in the CS group (29.7%) and in 20 patients in the MP group (22%). Using the
logistic regression model MP significantly reduced the risk of DGF compared
with CS (OR 0.460, P = 0.047). The incidence of nonfunction in the CS group
(12%) was four times higher than in the MP group (3%) (P = 0.04). One-year
graft survival was significantly higher in machine perfused kidneys compared
with cold stored kidneys (92.3% vs. 80.2%, P = 0.02). In the present study,
MP preservation clearly reduced the risk of DGF and improved 1-year graft
survival and function in ECD kidneys.
Disciplines :
Surgery
Author, co-author :
Treckmann, Jürgen
Moers, Cyril
Smits, Jacqueline M
Gallinat, Anja
Maathuis, Mark-Hugo J
van Kasterop-Kutz, Margitta
Jochmans, Ina
Homan van der Heide, Jaap J
SQUIFFLET, Jean-Paul ; Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
Bibliography
Port FK, Bragg-Gresham JL, Metzger RA, et al. Donor characteristics associated with reduced graft survival: an approach to expanding the pool of kidney donors. Transplantation 2002; 74: 1281.
Metzger RA, Delmonico FL, Feng S, Port FK, Wynn JJ, Merion RM,. Expanded criteria donors for kidney transplantation. Am J Transplant 2003; 3 (Suppl. 4): 114.
Pascual J, Zamora J, Pirsch JD,. A systematic review of kidney transplantation from expanded criteria donors. Am J Kidney Dis 2008; 52: 553.
Daly PJ, Power RE, Healy DA, Hickey DP, Fitzpatrick JM, Watson RW,. Delayed graft function: a dilemma in renal transplantation. BJU Int 2005; 96: 498.
McLaren AJ, Jassem W, Gray DW, Fuggle SV, Welsh KI, Morris PJ,. Delayed graft function: risk factors and the relative effects of early function and acute rejection on long-term survival in cadaveric renal transplantation. Clin Transplant 1999; 13: 266.
Troppmann C, Gillingham KJ, Benedetti E, et al. Delayed graft function, acute rejection, and outcome after cadaver renal transplantation. The multivariate analysis. Transplantation 1995; 59: 962.
Ojo AO, Hanson JA, Meier-Kriesche H, et al. Survival in recipients of marginal cadaveric donor kidneys compared with other recipients and wait-listed transplant candidates. J Am Soc Nephrol 2001; 12: 589.
Wight J, Chilcott J, Holmes M, Brewer N,. The clinical and cost-effectiveness of pulsatile machine perfusion versus cold storage of kidneys for transplantation retrieved from heart-beating and non-heart-beating donors. Health Technol Assess 2003; 7: 1.
Wight JP, Chilcott JB, Holmes MW, Brewer N,. Pulsatile machine perfusion vs. cold storage of kidneys for transplantation: a rapid and systematic review. Clin Transplant 2003; 17: 293.
Moers C, Smits JM, Maathuis MH, et al. Machine perfusion or cold storage in deceased-donor kidney transplantation. N Engl J Med 2009; 360: 7.
Polyak MM, Arrington BO, Stubenbord WT, et al. The influence of pulsatile preservation on renal transplantation in the 1990s. Transplantation 2000; 69: 249.
Boom H, de Fijter J,. Delayed graft function in renal transplantation. Transplant Rev 2004; 18: 139.
Saidi RF, Elias N, Kawai T, et al. Outcome of kidney transplantation using expanded criteria donors and donation after cardiac death kidneys: realities and costs. Am J Transplant 2007; 7: 2769.
Moore J, Tan K, Cockwell P, et al. Predicting early renal allograft function using clinical variables. Nephrol Dial Transplant 2007; 22: 2669.
Buchanan PM, Lentine KL, Burroughs TE, Schnitzler MA, Salvalaggio PR,. Association of lower costs of pulsatile machine perfusion in renal transplantation from expanded criteria donors. Am J Transplant 2008; 8: 2391.
Matsuoka L, Shah T, Aswad S, et al. Pulsatile perfusion reduces the incidence of delayed graft function in expanded criteria donor kidney transplantation. Am J Transplant 2006; 6: 1473.
Stratta RJ, Moore PS, Farney AC, et al. Influence of pulsatile perfusion preservation on outcomes in kidney transplantation from expanded criteria donors. J Am Coll Surg 2007; 204: 873; discussion 82.
Jochmans I, Moers C, Smits JM, et al. Renal resistance during machine perfusion is a risk factor for delayed graft function and poorer graft survival. Am J Transplant 2010; 10 (Suppl 4): 107.
Polyak MM, Arrington BO, Kapur S, Stubenbord WT, Kinkhabwala M,. Calcium ion concentration of machine perfusate predicts early graft function in expanded criteria donor kidneys. Transpl Int 1999; 12: 378.
Polyak M, Boykin J, Arrington B, Stubenbord WT, Kinkhabwala M,. Pulsatile preservation characteristics predict early graft function in extended criteria donor kidneys. Transplant Proc 1997; 29: 3582.
Hosgood SA, Yang B, Bagul A, Mohamed IH, Nicholson ML,. A comparison of hypothermic machine perfusion versus static cold storage in an experimental model of renal ischemia reperfusion injury. Transplantation 2010; 89: 830.
Yuan X, Theruvath AJ, Ge X, et al. Machine perfusion or cold storage in organ transplantation: indication, mechanisms, and future perspectives. Transpl Int 2010; 23: 561.
Nyberg SL, Baskin-Bey ES, Kremers W, Prieto M, Henry ML, Stegall MD,. Improving the prediction of donor kidney quality: deceased donor score and resistive indices. Transplantation 2005; 80: 925.
Similar publications
Sorry the service is unavailable at the moment. Please try again later.
This website uses cookies to improve user experience. Read more
Save & Close
Accept all
Decline all
Show detailsHide details
Cookie declaration
About cookies
Strictly necessary
Performance
Strictly necessary cookies allow core website functionality such as user login and account management. The website cannot be used properly without strictly necessary cookies.
This cookie is used by Cookie-Script.com service to remember visitor cookie consent preferences. It is necessary for Cookie-Script.com cookie banner to work properly.
Performance cookies are used to see how visitors use the website, eg. analytics cookies. Those cookies cannot be used to directly identify a certain visitor.
Used to store the attribution information, the referrer initially used to visit the website
Cookies are small text files that are placed on your computer by websites that you visit. Websites use cookies to help users navigate efficiently and perform certain functions. Cookies that are required for the website to operate properly are allowed to be set without your permission. All other cookies need to be approved before they can be set in the browser.
You can change your consent to cookie usage at any time on our Privacy Policy page.
