estradiol; progesterone; pheromone; sexual differentiation; Fos expression
Abstract :
[en] Previously [D.W. Wesson, M. Keller, Q. Douhard, M.J. Baum, J. Bakker, Enhanced urinary odor discrimination in female aromatase knockout mice, Horm. Behav. 49 (2006) 580-586] female aromatase knock out mice successfully learned to discriminate in a food-motivated go/no-go task between urinary volatiles from ovariectomized female mice treated with estradiol as opposed to estradiol plus progesterone whereas wild type females failed to learn this odor discrimination. We asked whether this behavioral difference is reflected in the ability of these two types of urinary volatiles to differentially stimulate Fos expression in juxtaglomerular cells (an index of glomerular activation) of the main olfactory bulb (MOB) in wild type versus ArKO female mice. Statistically significant differences in the profiles of MOB glomerular activation were seen in ovariectomized, estrogen-treated ArKO as well as WT female subjects following exposure to urinary volatiles from ovariectomized females given estradiol alone as opposed to estradiol plus progesterone. Therefore, previously observed differences between females of the two genotypes in their behavioral responses to these odors must reflect differential processing in more central segments of the olfactory pathway instead of in the MOB. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
Research center :
Giga-Neurosciences - ULiège
Disciplines :
Neurosciences & behavior
Author, co-author :
Martel, K. L.
Keller, Matthieu ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau
Douhard, Quentin ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau
Bakker, Julie ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau
Baum, M. J.
Language :
English
Title :
Comparison of urinary odor-induced glomerular activation in the main olfactory bulb of aromatase knock-out and wild type female mice
Publication date :
27 June 2007
Journal title :
Neuroscience Letters
ISSN :
0304-3940
eISSN :
1872-7972
Publisher :
Elsevier Ireland Ltd, Clare, Ireland
Volume :
421
Issue :
2
Pages :
101-105
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
NICHD - National Institutes of Health. Eunice Kennedy Shriver National Institute of Child Health and Human Development [US-MD] [US-MD]
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