[en] The importance of estrogens in controlling brain and behavioral sexual differentiation in female rodents is an unresolved issue in the field of behavioral neuroendocrinology. Whereas, the current dogma states that the female brain develops independently of estradiol, many studies have hinted at possible roles of estrogen in female sexual differentiation. Accordingly, it has been proposed that alpha-fetoprotein, a fetal plasma protein that binds estrogens with high affinity, has more than a neuroprotective role and specifically delivers estrogens to target brain cells to ensure female differentiation. Here, we review new results obtained in aromatase and alpha-fetoprotein knockout mice showing that estrogens can have both feminizing and defeminizing effects on the developing neural mechanisms that control sexual behavior. We propose that the defeminizing action of estradiol normally occurs prenatally in males and is avoided in fetal females because of the protective actions of alpha-fetoprotein, whereas the feminizing action of estradiol normally occurs postnatally in genetic females.
Research Center/Unit :
Giga-Neurosciences - ULiège
Disciplines :
Neurology
Author, co-author :
Bakker, Julie ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau
Baum, M. J.
Language :
English
Title :
Role for Estradiol in Female-Typical Brain and Behavioral Sexual Differentiation
Publication date :
January 2008
Journal title :
Frontiers in Neuroendocrinology
ISSN :
0091-3022
eISSN :
1095-6808
Publisher :
Elsevier, Atlanta, United States - Florida
Volume :
29
Issue :
1
Pages :
1-16
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
NICHD - National Institutes of Health. Eunice Kennedy Shriver National Institute of Child Health and Human Development
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
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