[en] BACKGROUND: The endocrine control of sebaceous follicles is complex in women. During aging, a decline in sebum output is often experienced. However, some women report increased seborrhea after the menopause. OBJECTIVE: In this study, the follicular reservoir function was studied during the first decade following the menopause. METHODS: Four evaluations were made at 3-week intervals in two parallel age-matched groups of 50 postmenopausal women receiving hormone replacement therapy (HRT) or not. The Sebumeter served to measure the casual sebum level and the sebum excretion rate on the forehead. In addition, a Visioscan equipped with an ultraviolet-recording camera was used with and without lipid-sensitive tapes interposed between the camera and the skin surface. Follicular openings and sebum pore patterns were studied by image analysis. RESULTS: There was enormous diversity among individual values of sebum output at the skin surface. In untreated women, a significant decline in sebum excretion rate accompanied by an increase in both the sebum replacement time and the mean pore size were evidenced during the first decade after the menopause. The sebum excretion rate and casual level showed a wide range of interindividual differences early after the menopause. These physiological changes were less prominent in women receiving HRT. CONCLUSION: Postmenopausal aging affects the sebum production, but HRT does not significantly control the complex process of seborrhea. However, HRT mitigates the progressive enlargement of the openings of the sebum follicular reservoir.
Disciplines :
Dermatology
Author, co-author :
Pierard, Claudine ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Pierard, Gérald ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Language :
English
Title :
Postmenopausal aging of the sebaceous follicle: a comparison between women receiving hormone replacement therapy or not.
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Bibliography
Choudhry R., Hodgins M.B., Van Der Kwast T.H., Brinkmann A.O., Boersma W.J.A. (1992) Localisation of androgen receptors in human skin by immunohistochemistry: Implications for the hormonal regulation of hair growth, sebaceous glands and sweat glands. J Endocrinol 133:467-475.
Imperato-McGinley J., Gautier T., Cai L.Q., Yee B., Epstein J., Pochi P. (1993) The androgen control of sebum production: Studies of subjects with dihydrotestosterone deficiency and complete androgen insensibility. J Clin Endocrinol Metab 76:524-528.
Giltay E.J., Gooren L.J.G. (2000) Effects of sex steroid deprivation/administration on hair growth and skin sebum production in transsexual males and females. J Clin Endocrinol 85:2913-2921.
Deplewski D., Rosenfield R.L. (1999) Growth hormone and insulin-like growth factors have different effects on sebaceous cell growth and differentiation. Endocrinology 140:4089-4094.
Callens A., Vaillant L., Lecomte P., Berson M., Gall Y., Lorette G. (1996) Does hormonal skin aging exist? A study of the influence of different hormone therapy regimens on the skin of postmenopausal women using non-invasive measurement techniques. Dermatology 193:289-294.
Piérard G.E., Letawe C., Piérard-Franchimont C., Gaspard U. (1998) Analytic quantification of skin changes during climacteric aging and hormone replacement therapy. Women Aging and Health: Facts, Research and Intervention , Vellas B, Albarede JL, Garry PJ (eds): Geriatrics Ser. Paris, Serdi, New York, Springer; 167-176.
Pochi P.E., Strauss J.S., Downing D. (1979) Age-related changes in sebaceous gland activity. J Invest Dermatol 73:108-111.
Jacobsen E., Billings J.K., Frantz R.A., Kinney C.K., Stewart M.E., Downing D.T. (1985) Age-related changes in sebum secretion rate in men and women. J Invest Dermatol 85:483-485.
Downing D.T., Stewart M.E., Strauss J.S. (1986) Changes in sebum secretion and the sebaceous gland. Dermatol Clin 4:419-423.
Luderschmidt C., Kinderman D. (1987) Sebostasis of the aged. G Ital Chir Dermatol Oncol 2:192-200.
Piérard G.E., Pírard-Franchimont C., Lě T., Lapière C.M. (1987) Patterns of follicular sebum excretion rate during lifetime. Arch Dermatol Res 279.
Piérard G.E., Piérard-Franchimont C., Marks R., Paye M., Rogiers V. (2000) EEMCO guidance for the in vivo evaluation of skin greasiness. Skin Pharmacol Appl Physiol 13:372-389.
Piérard G.E. (1996) The quandary of climacteric skin ageing. Dermatology 193:273-274.
Piérard G.E., Letawe C., Dowlati A., Pírard-Franchimont C. (1995) Effect of hormone replacement therapy for menopause on the mechanical properties of skin. J Am Geriatr Soc 43:662-665.
Castelo-Branco C., Figueras F., Martinez de Osaba M.J., Vanrell J.A. (1998) Facial wrinkling in postmenopausal women: Effects of smoking status and hormone replacement therapy. Maturitas 29:75-86.
Piérard-Franchimont C., Cornil F., Dehavay J., Letot B., Deleixhe-Mauhin F., Piérard G.E. (1999) Climacteric skin ageing of the face: A prospective longitudinal intent-to-treat on the effect of oral hormone replacement therapy. Maturitas 32:87-93.
Piérard G.E., Piérard-Franchimont C., Vanderplaetsen S., Franchimont N., Gaspard U., Malaise M. (2001) Relationship between bone mass density and tensile strength of the skin in women. Eur J Clin Invest 31:731-735.
Paquet F., Piérard-Franchimont C., Fumal I., Goffin V., Paye M., Piérard G.E. (1998) Sensitive skin at menopause: Dew point and electrometric properties of the stratum corneum. Maturitas 28:221-227.
Piérard-Franchimont C., Gaspard U., Lacante P., Slachmuylders P., Piérard G.E. (2000) A quantitative biometrological assessment of acne and hormonal evaluation in young women using a triphasic low-dose oral contraceptive containing gestodene. Eur J Contracept Repr Health Care 5:275-286.
Piérard G.E., Cauwenbergh G. (1996) Modulation of sebum excretion from the follicular reservoir by a dichlorophenylimidazoldioxolan. Int J Cosmet Sci 18:219-228.
Piérard G.E., Ries G., Cauwenbergh G. (1998) New insight in the topical management of excessive sebum flow at the skin surface. Dermatology 196:126-129.
Piérard-Franchimont C., Martalo O., Richard A., Rougier A., Piérard G.E. (1999) Sebum rheology evaluated by two methods in vivo: Split-face study of the effect of a cosmetic formulation. Eur J Dermatol 9:455-457.
Bläuler M., Vaalasti A., Pauli S.L., Ylikomi T., Joensuu T., Tuohimaa P. (1997) Location of androgen receptor in human skin. J Invest Dermatol 97:264-268.
Liang T., Hoyer S., Yu R., Soltani K., Lorincz A.L., Hiipakka R.A., Liao S. (1993) Immunocytochemical localization of androgen receptors in human skin using monoclonal antibodies against the androgen receptor. J Invest Dermatol 100:663-666.
Thiboutot D., Knaggs H., Gilliland K., Lin G. (1998) Activity of 5α-reductase and 17β-hydroxysteroid dehydrogenase in the infrainfundibulum of subjects with and without acne vulgaris. Dermatology 196:38-42.
Plewig G., Kligman A.M. (1978) Proliferative activity of the sebaceous glands of the aged. J Invest Dermatol 70:314-317.
Guy R., Kealy T. (1998) Modeling the infundibulum in acne. Dermatology 196:32-37.
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