[en] Migraine patients show interictally a strong intensity dependence of auditory evoked cortical potentials (IDAP) and a lack of habituation of evoked potentials. Photic drive on high-frequency flash stimulation is another well-known interictal feature in migraineurs, associated with alpha-rhythm hyper-synchronisation. We compared therefore the influence of light stimulation on IDAP in healthy volunteers (HV) and migraine patients. A continuous flash stimulation was delivered during the recording of auditory evoked potentials at suprathreshold increasing stimulation intensities. IDAP was measured as the amplitude/stimulus intensity function (ASF) slope. In HV, the ASF slope decreased during flash stimulation, whereas, on average, there was no significant change in migraineurs. A closer analysis of migraineurs disclosed two subgroups of patients with no detectable clinical differences: one, the largest, in which the ASF slope was normal at baseline, but increased during light stimulation, the other with an increased ASF slope at rest and a decrease during light interference. Visual sensory overload is able to increase IDAP in the majority of migraineurs, which contrasts with HV. We hypothesise that this could be due to hyper-synchronisation of the alpha rhythm because of photic drive and possibly thalamo-cortical dysfunction. A minority of migraineurs have, like HV, an IDAP reduction during light interference. They are, however, characterised, unlike most HV, by a high IDAP at baseline. Besides underscoring the pathophysiological heterogeneity of migraine, these results suggest that light interference might improve the phenotyping of migraine patients who have a normal IDAP in the resting condition.
Disciplines :
Neurosciences & behavior Neurology
Author, co-author :
Ambrosini, Anna
Coppola, Gianluca
Gerardy, Pierre-Yves
Pierelli, Francesco
Schoenen, Jean ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie
Language :
English
Title :
Intensity dependence of auditory evoked potentials during light interference in migraine.
Publication date :
2011
Journal title :
Neuroscience Letters
ISSN :
0304-3940
eISSN :
1872-7972
Publisher :
Elsevier, Netherlands
Volume :
492
Issue :
2
Pages :
80-3
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
Bibliography
Afra J., Proietti Cecchini A., Sándor P.S., Schoenen J. Comparison of visual and auditory evoked cortical potentials in migraine patients between attacks. Clin. Neurophysiol. 2000, 111:1124-1129.
Ambrosini A., De Pasqua V., Afra J., Sandor P.S., Schoenen J. Reduced gating of middle-latency auditory evoked potentials (P50) in migraine patients: another indication of abnormal sensory processing?. Neurosci. Lett. 2001, 306:132-134.
Ambrosini A., Rossi P., De Pasqua V., Pierelli F., Schoenen J. Lack of habituation causes high intensity dependence of auditory evoked cortical potentials in migraine. Brain 2003, 126:2009-2015.
Ambrosini A., Schoenen J. Electrophysiological response patterns of primary sensory cortices in migraine. J. Headache Pain 2006, 7:377-388. Review.
Coppola G., Ambrosini A., Di Clemente L., Magis D., Fumal A., Gérard P., Pierelli F., Schoenen J. Interictal abnormalities of gamma band activity in visual evoked responses in migraine: an indication of thalamocortical dysrhythmia?. Cephalalgia 2007, 27:1360-1367.
Coppola G., Vandenheede M., Di Clemente L., Ambrosini A., Fumal A., De Pasqua V., Schoenen J. Somatosensory evoked high-frequency oscillations reflecting thalamo-cortical activity are decreased in migraine patients between attacks. Brain 2005, 128:98-103.
Costa J., Valls-Sole J., Valldeoriola F., Rumia J. Subcortical interactions between somatosensory stimuli of different modalities and their temporal profile. J. Neurophysiol. 2008, 100:1610-1621.
de Tommaso M., Marinazzo D., Guido M., Libro G., Stramaglia S., Nitti L., Lattanti G., Angelini L., Pellicoro M. Visually evoked phase synchronization changes of alpha rhythm in migraine: correlations with clinical features. Int. J. Psychophysiol. 2005, 57:203-210.
Edgar J.C., Miller G.A., Moses S.N., Thoma R.J., Huang M.-X., Hanlon F.M., Weisend M.P., Sherwood A., Bustillo J., Adler L.E., Canive J.M. Cross-modal generality of the gating deficit. Psychophysiology 2005, 42:318-327.
Golla F.L., Winter A.L. Analysis of cerebral responses to flicker in patients complaining of episodic headache. Electroencephalogr. Clin. Neurophysiol. 1959, 11:539-549.
Headache Classification Subcommittee of the International Headache Society The International Classification of Headache Disorders - 2nd Edition. Cephalalgia 2004, 24(Suppl. 1):1-160.
Hegerl U., Juckel G. Intensity dependence of auditory evoked potentials as an indicator of central serotonergic neurotransmission: a new hypothesis. Biol. Psychiatry 1993, 33:173-187. Review.
Jin Y., Potkin S.G. P50 changes with visual interference in normal subjects: a sensory distraction model for schizophrenia. Clin. Electroencephalogr. 1996, 27:151-154.
Koch S.P., Koendgen S., Bourayou R., Steinbrink J., Obrig H. Individual alpha-frequency correlates with amplitude of visual evoked potential and hemodynamic response. NeuroImage 2008, 41:233-242.
Lebib R., Papo D., de Bode S., Baudonnière P.M. Evidence of a visual-to-auditory cross-modal sensory gating phenomenon as reflected by the human P50 event-related brain potential modulation. Neurosci. Lett. 2003, 341:185-188.
Lopes da Silva F. Neural mechanisms underlying brain waves: from neural membranes to networks. Electroencephalogr. Clin. Neurophysiol. 1991, 79:81-93.
McCormick D.A., Bal T. Sensory gating mechanisms of the thalamus. Curr. Opin. Neurobiol. 1994, 4:550-556.
Pfurtscheller G., Lopes da Silva F.H. Event-related EEG/MEG synchronization and desynchronization: basic principles. Clin. Neurophysiol. 1999, 110:1842-1857.
Pum M.E., Huston J.P., De Souza Silva M.A., Müller C.P. Visual sensory-motor gating by serotonin activation in the medial prefrontal and occipital, but not in the rhinal, cortices in rats. Neuroscience 2008, 153:361-372.
Schoenen J Deficient habituation of evoked potentials in migraine: a link between brain biology, behaviour and trigeminovascular activation?. Biomed. Pharmacother. 1996, 50:71-78.
Siniatchkin M., Kropp P., Gerber W.D. What kind of habituation is impaired in migraine patients?. Cephalalgia 2003, 23:511-518.
Thut G., Theoret A., Pfennig J., Ives F., Kampmann G., Northoff G., Pascual-Leone A. Differential effects of low-frequency rTMS at the occipital pole on visual-induced alpha desynchronization and visual evoked potentials. NeuroImage 2003, 18:334-347.
Wang W., Timsit-Berthier M., Schoenen J. Intensity dependence of auditory evoked potentials is pronounced in migraine: an indication of cortical potentiation and low serotonergic neurotransmission?. Neurology 1996, 46:1404-1409.
Wutzler A., Winter C., Kitzrow W., Uhl I., Wolf R.J., Heinz A., Juckel G. Loudness dependence of auditory evoked potentials as indicator of central serotonergic neurotransmission: simultaneous electrophysiological recordings and in vivo microdialysis in the rat primary auditory cortex. Neuropsychopharmacology 2008, 33:3176-3181.
Antal A., Arlt S., Nitsche M.A., Chadaide Z., Paulus W. Higher variability of phosphene thresholds in migraineurs than in controls: a consecutive transcranial magnetic stimulation study. Cephalalgia 2006, 26:865-870.
Bjørk M.H., Stovner L.J., Nilsen B.M., Stjern M., Hagen K., Sand T. The occipital alpha rhythm related to the "migraine cycle" and headache burden: a blinded, controlled longitudinal study. Clin. Neurophysiol. 2009, 120:464-471.
This website uses cookies to improve user experience. Read more
Save & Close
Accept all
Decline all
Show detailsHide details
Cookie declaration
About cookies
Strictly necessary
Performance
Strictly necessary cookies allow core website functionality such as user login and account management. The website cannot be used properly without strictly necessary cookies.
This cookie is used by Cookie-Script.com service to remember visitor cookie consent preferences. It is necessary for Cookie-Script.com cookie banner to work properly.
Performance cookies are used to see how visitors use the website, eg. analytics cookies. Those cookies cannot be used to directly identify a certain visitor.
Used to store the attribution information, the referrer initially used to visit the website
Cookies are small text files that are placed on your computer by websites that you visit. Websites use cookies to help users navigate efficiently and perform certain functions. Cookies that are required for the website to operate properly are allowed to be set without your permission. All other cookies need to be approved before they can be set in the browser.
You can change your consent to cookie usage at any time on our Privacy Policy page.