Article (Scientific journals)
Cognitive deficits in patients with chronic fatigue syndrome compared to those with major depressive disorder and healthy controls
Constant, Eric; Adam, Stéphane; Gillain, Benoît et al.
2011In Clinical Neurology and Neurosurgery, 113 (4), p. 295-302
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Keywords :
Chronic Fatigue Syndrom; Cognitive deficit; Depression
Abstract :
[en] Object: It is frequently reported that cognitive complaints accompany the chronic fatigue syndrome (CFS). However, studies on cognition in CFS have yielded conflicting results. The neuropsychological literature on this subject is plagued by methodological difficulties, including, for example, the existence of comorbid depression, which is also associated with cognitive impairments. Patients and Methods: Twenty-five patients with CFS, 25 patients with major depressive disorder (MDD), and 25 healthy control subjects were given standardized tests of attention, working memory, and verbal and visual episodic memory, and were also tested for effects related to lack of effort/simulation, suggestibility, and fatigue. Results: Patients with CFS had slower phasic alertness, and also had impaired working, visual and verbal episodic memory compared to controls. They were, however, no more sensitive than the other groups to suggestibility or to fatigue induced during the cognitive session. Cognitive impairments in MDD patients were strongly associated with depression and subjective fatigue; in patients with CFS, there was a weaker correlation between cognition and depression (and no correlation with fatigue). Conclusions: This study confirms the presence of an objective impairment in attention and memory in patients with CFS but with good mobilization of effort and without exaggerated suggestibility.
Disciplines :
Neurosciences & behavior
Author, co-author :
Constant, Eric
Adam, Stéphane  ;  Université de Liège - ULiège > Département de personne et société > Psychologie de la sénescence
Gillain, Benoît
Lambert, Michel
Masquelier, Etienne
Seron, Xavier
Language :
English
Title :
Cognitive deficits in patients with chronic fatigue syndrome compared to those with major depressive disorder and healthy controls
Publication date :
May 2011
Journal title :
Clinical Neurology and Neurosurgery
ISSN :
0303-8467
eISSN :
1872-6968
Publisher :
Elsevier, Amsterdam, Netherlands
Volume :
113
Issue :
4
Pages :
295-302
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 21 April 2011

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