Malignant tumor; Diseases of the osteoarticular system; Radionuclide study; Bronchus disease; Lung disease; Respiratory disease; Glucose; Radiolabelling; Fluorite; Positron; Emission tomography; Sensitivity; Evaluation; Diagnosis; Bone; Metastasis; Non small cell carcinoma; Human; Bronchopulmonary; Tumeur maligne; Exploration radioisotopique; Système ostéoarticulaire pathologie; Bronche pathologie; Poumon pathologie; Appareil respiratoire pathologie; Marquage radioisotopique; Fluorine; Positon; Tomoscintigraphie; Sensibilité; Diagnostic; Os; Métastase; Carcinome non petite cellule; Homme; Bronchopulmonaire
Abstract :
[en] Despite advances in morphological imaging, some patients with lung cancer are found to have non resectable disease at surgery or die of recurrence within a year of surgery. At present, metastatic bone involvement is usually assessed using bone scintigraphy, which has a high sensitivity but a poor specificity. We have attempted to evaluate the utility of the fluorine-18 deoxyglucose positron emission tomography (FDG PET) for the detection of bone metastasis. One hundred and ten consecutive patients with histological diagnosis of non-small cell lung cancer (NSCLC) who underwent both FDG PET and bone scintigraphy were selected for this review. In this group, there were 43 patients with metastatic disease (stage IV). Among these. 21 (19% of total group) had one or several bone metastases confirmed by biopsy (n = 8) or radiographic techniques (n = 13). Radionuclide bone scanning correctly identified 54 out of 89 cases without osseous involvement and 19 out of 21 osseous involvements. On the other hand, FDG PET correctly identified the absence of osseous involvement in 87 out of 89 patients and the presence of bone metastasis in 19 out of 21 patients. Thus using PET there were two false-negative and two false-positive cases. PET and bone scanning had, respectively, an accuracy of 96% and 66% in the evaluation of osseous involvement in patients with NSCLC. In conclusion, our data suggest that whole-body FDG PET may be useful in detecting bone metastases in patients with known NSCLC.
Disciplines :
Oncology
Author, co-author :
Bury, Thierry ; Université de Liège - ULiège > Département des sciences de la motricité > Physiologie humaine et physiologie de l'effort physique
BARRETO, A.; Centre Hospitalier Universitaire de Liège - CHU > Nuclear Medicine
Daenen, Frédéric ; Centre Hospitalier Universitaire de Liège - CHU > Nuclear Medicine
BARTHELEMY, Nicole ; Centre Hospitalier Universitaire de Liège - CHU > Radiothérapie
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