Article (Scientific journals)
Are the creatinine-based equations accurate to estimate glomerular filtration rate in african american populations ?
DELANAYE, Pierre; MARIAT, Christophe; MAILLARD, Nicolas et al.
2011In Clinical Journal of the American Society of Nephrology, 6, p. 906-912
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Abstract :
[en] Regarding the high prevalence of African American patients with ESRD, it is important to estimate the prevalence of early stages of chronic kidney disease in this specific population. Because serum creatinine concentration is dependent on muscular mass, an ethnic factor has to be applied to creatinine-based equations. Such ethnic factors have been proposed in the Modification of Diet in Renal Disease (MDRD) study equation and in the more recent Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations. This review analyzes how these correction factors have been developed and how they have, or have not, been validated in external populations. It will be demonstrated that the African American factor in the MDRD study equation is accurate in African American chronic kidney disease (CKD) patients. However, it will be shown that this factor is probably too high for subjects with a GFR of >60 ml/min per 1.73 m2, leading to an underestimation of the prevalence of CKD in the global African American population. It will also be confirmed that this ethnic factor is not accurate in African (non-American) subjects. Lastly, the lack of true external validation of the new CKD-EPI equations will be discussed. Additional trials seem necessary in American African and African populations to better estimate GFR and apprehend the true prevalence of CKD in this population with a high renal risk.
Disciplines :
Urology & nephrology
Laboratory medicine & medical technology
Author, co-author :
DELANAYE, Pierre  ;  Centre Hospitalier Universitaire de Liège - CHU > Néphrologie
MARIAT, Christophe
MAILLARD, Nicolas
KRZESINSKI, Jean-Marie ;  Centre Hospitalier Universitaire de Liège - CHU > Néphrologie
CAVALIER, Etienne  ;  Centre Hospitalier Universitaire de Liège - CHU > Chimie médicale
Language :
English
Title :
Are the creatinine-based equations accurate to estimate glomerular filtration rate in african american populations ?
Publication date :
April 2011
Journal title :
Clinical Journal of the American Society of Nephrology
ISSN :
1555-9041
eISSN :
1555-905X
Publisher :
American Society of Nephrology
Volume :
6
Pages :
906-912
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 04 April 2011

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