Are the creatinine-based equations accurate to estimate glomerular filtration rate in african american populations ?

Regarding the high prevalence of African American patients with ESRD, it is important to estimate the prevalence
of early stages of chronic kidney disease in this specific population. Because serum creatinine concentration
is dependent on muscular mass, an ethnic factor has to be applied to creatinine-based equations. Such
ethnic factors have been proposed in the Modification of Diet in Renal Disease (MDRD) study equation and
in the more recent Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations. This review analyzes
how these correction factors have been developed and how they have, or have not, been validated in
external populations. It will be demonstrated that the African American factor in the MDRD study equation is
accurate in African American chronic kidney disease (CKD) patients. However, it will be shown that this factor
is probably too high for subjects with a GFR of >60 ml/min per 1.73 m2, leading to an underestimation
of the prevalence of CKD in the global African American population. It will also be confirmed that this ethnic
factor is not accurate in African (non-American) subjects. Lastly, the lack of true external validation of the
new CKD-EPI equations will be discussed. Additional trials seem necessary in American African and African
populations to better estimate GFR and apprehend the true prevalence of CKD in this population with a high
renal risk.