Effectors of Inflammation in Actinic Prurigo

Arrese, J. E.; Dominguez-Soto, L.; Hojyo-Tomoka, M. T.; Vega-Memije, E.; Cortes-Franco, R.; Guevara, E.; Pierard, Gérald

doi:10.1067/mjd.2001.113477

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Effectors of Inflammation in Actinic Prurigo

Arrese, J. E.; Dominguez-Soto, L.; Hojyo-Tomoka, M. T. et al.

2001 • In Journal of the American Academy of Dermatology, 44 (6), p. 957-61

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https://hdl.handle.net/2268/88005

DOI
10.1067/mjd.2001.113477

PubMed
11369907

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Abstract :

[en] BACKGROUND: Actinic prurigo is a specific familial photodermatosis of uncertain pathogenesis. OBJECTIVE: Our purpose was to investigate the immunohistologic presentation of actinic prurigo to explore the involved pathomechanisms. METHODS: The present immunohistochemical study was performed on biopsy specimens from 20 Mexican patients presenting with a severe and perennial form of the disease. RESULTS: The dense inflammatory infiltrate was composed predominantly of helper T type 1 lymphocytes admixed with scattered B-cell lymphoid follicles and numerous dermal dendrocytes. Keratinocytes contained abundant tumor necrosis factor-alpha and calprotectin. CONCLUSION: In subjects genetically predisposed to actinic prurigo, ultraviolet light may trigger excessive tumor necrosis factor-alpha production by keratinocytes whose sustained release in turn exerts its proinflammatory activity and deleterious epidermal effects. Such a cascade of events is in line with the therapeutic benefit already reported when thalidomide is used to treat actinic prurigo.

Disciplines :

Dermatology

Author, co-author :

Arrese, J. E.

Dominguez-Soto, L.

Hojyo-Tomoka, M. T.

Vega-Memije, E.

Cortes-Franco, R.

Guevara, E.

Pierard, Gérald ; Université de Liège - ULiège > Département des sciences cliniques > Dermatopathologie

Language :

English

Title :

Effectors of Inflammation in Actinic Prurigo

Publication date :

June 2001

Journal title :

Journal of the American Academy of Dermatology

ISSN :

0190-9622

eISSN :

1097-6787

Publisher :

Mosby, United States - New York

Volume :

Issue :

Pages :

957-61

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 31 March 2011

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