Reference : The role of the thymus in integrated evolution of the recombinase-dependent adaptive ...
Scientific journals : Article
Human health sciences : Multidisciplinary, general & others
Human health sciences : Immunology & infectious disease
Human health sciences : Endocrinology, metabolism & nutrition
The role of the thymus in integrated evolution of the recombinase-dependent adaptive immune response and the neuroendocrine system
Mottet, Marie mailto [Université de Liège - ULiège > > Centre d'immunologie >]
Goffinet, Lindsay [Université de Liège - ULiège > > Centre d'immunologie >]
Beckers, Alisson [Université de Liège - ULiège > Centre d'Immunologie > > >]
Bodart, Gwennaëlle mailto [Université de Liège - ULiège > > > Doct. sc. bioméd. & pharma. (Bologne)]
Morrhaye, Gabriel [Université de Liège - ULiège > Centre d'Immunologie > > >]
Kermani, Hamid [Université de Liège - ULiège > Centre d'Immunologie > > >]
RENARD-CHARLET, Jeanne de Chantal [Centre Hospitalier Universitaire de Liège - CHU > > Endocrinologie clinique >]
Martens, Henri mailto [Université de Liège - ULiège > > Centre d'immunologie >]
Geenen, Vincent mailto [Université de Liège - ULiège > > Centre d'immunologie >]
S. Karger
Neuroendocrinology of the thymus
Yes (verified by ORBi)
[en] Thymus ; Self-tolerance ; Neuroendocrine self-antigens ; Autoimmunity ; Evolution
[en] Before being able to react against infectious non-self antigens, the immune system has to be educated in recognition and tolerance of neuroendocrine self-proteins. This sophisticated educational process takes place only in the thymus. The development of an autoimmune response directed to neuroendocrine glands has been shown to result from a thymus dysfunction in programming immunological self-tolerance to neuroendocrine-related antigens. This thymus dysfunction leads to a breakdown of immune homeostasis with an enrichment of ‘forbidden’ self-reactive T cells and a deficiency in self-antigen specific natural regulatory T cells (nTreg) in the peripheral T-lymphocyte repertoire. A large number of neuroendocrine self-antigens are expressed by the thymic epithelium, under the control of the autoimmune regulator (AIRE) gene/protein in the medulla. Based on the close homology and cross-tolerance between thymic type 1 diabetes-related self-antigens and peripheral antigens targeted in β cells by autoimmunity, a novel type of vaccination is currently developed for prevention and cure of type 1 diabetes. If this approach were found to be effective in reprogramming immunological tolerance that is absent or broken in this disease, it could pave the way for the design of negative/tolerogenic self-vaccines against other endocrine and organ-specific autoimmune disorders.
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Fonds Léon Fredericq ; Région wallonne : Direction générale des Technologies, de la Recherche et de l'Energie - DGTRE ; Union Européenne = European Union - UE = EU ; European Association for the Study of Diabetes (EASD) ; Juvenile Diabetes Research Federation (JDRF, New York)
Tolediab - Eurothymaide
Researchers ; Professionals ; Students

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