Transcriptomic biomarkers of the response of hospitalized geriatric patients admitted with heart failure. Comparison to hospitalized geriatric patients with infectious diseases or hip fracture

Vo, Thi Kim Duy; de Saint-Hubert, Marie; Morrhaye, Gabriel; Godard, Patrice; Geenen, Vincent; Martens, Henri; Debacq-Chainiaux, Florence; Swine, Christian; Toussaint, Olivier

doi:10.1016/j.mad.2011.02.002

Article (Scientific journals)

Transcriptomic biomarkers of the response of hospitalized geriatric patients admitted with heart failure. Comparison to hospitalized geriatric patients with infectious diseases or hip fracture

Vo, Thi Kim Duy; de Saint-Hubert, Marie; Morrhaye, Gabriel et al.

2011 • In Mechanisms of Ageing and Development, 132, p. 131-139

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/87495

DOI
10.1016/j.mad.2011.02.002

PubMed
21335025

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Keywords :

Ageing; Gene expression; Heart failure; Inflammation; Immunosenescence; Oxidative stress

Abstract :

[en] The abundance of a preselection of transcripts involved in inflammation, immunosenescence and stress response was compared between PBMC of healthy aged donors and aged patients in acute phase of heart failure and at recovery. This study identified 22 transcripts differentially abundant in acute phase of heart failure versus healthy aged subjects. Transcripts involved in inflammation and oxidative stress weremore abundant. Those associated with T-cell functions were less abundant. The results were compared to two other major acute geriatric issues: infectious diseases and hip fracture. In acute phase, compared to healthy aged subjects, the abundance of 15/22 transcripts was also altered in both geriatric infectious diseases and hip fracture. Many variations had not vanished at the recovery phase. The abundance of CD28, CD69, LCK, HMOX1, TNFRSF1A transcripts, known to be altered in healthy aged versus healthy young subjects, was further affected in acute phase of the three geriatric diseases considered. The transcript levels of BCL2, CASP8, CCL5, DDIT3, EGR3, IL10RB, IL1R2, SERPINB2 and TIMP1 were affected in all three pathological conditions compared to healthy aged, but not versus healthy young subjects. In conclusion, this work provides critical targets for therapeutic research on geriatric heart failure, infectious diseases and hip fracture.

Disciplines :

Immunology & infectious disease
Geriatrics

Author, co-author :

Vo, Thi Kim Duy; Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Unité de recherche de biologie cellulaire

de Saint-Hubert, Marie; Université Catholique de Louvain - UCL > Gériatrie-Mont Godinne

Morrhaye, Gabriel; Université de Liège - ULiège > Centre d'Immunologie

Godard, Patrice; Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Unité de recherche de biologie cellulaire

Geenen, Vincent ; Université de Liège - ULiège > Centre d'immunologie

Martens, Henri ; Université de Liège - ULiège > Centre d'immunologie

Debacq-Chainiaux, Florence; Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Unité de recherche de biologie cellulaire

Swine, Christian; Université Catholique de Louvain - UCL > Gériatrie-Mont Godinne

Toussaint, Olivier; Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Unité de recherche de biologie cellulaire

Language :

English

Title :

Transcriptomic biomarkers of the response of hospitalized geriatric patients admitted with heart failure. Comparison to hospitalized geriatric patients with infectious diseases or hip fracture

Publication date :

2011

Journal title :

Mechanisms of Ageing and Development

ISSN :

0047-6374

Publisher :

Elsevier Science Ireland, Limerick, Ireland

Volume :

132

Pages :

131-139

Peer reviewed :

Peer Reviewed verified by ORBi

Name of the research project :

SENEGENE

Funders :

DGTRE - Région wallonne. Direction générale des Technologies, de la Recherche et de l'Énergie
F.R.S.-FNRS - Fonds de la Recherche Scientifique

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Adib-Conquy M., Adrie C., Fitting C., Gattolliat O., Beyaert R., Cavaillon J.M. Up-regulation of MyD88s and SIGIRR, molecules inhibiting Toll-like receptor signaling, in monocytes from septic patients. Crit. Care Med. 2006, 34:2377-2385.
Andreassen M., Raymond I., Kistorp C., Hildebrandt P., Faber J., Kristensen L.O. IGF1 as predictor of all cause mortality and cardiovascular disease in an elderly population. Eur. J. Endocrinol. 2009, 160:25-31.
Barton P.J., Birks E.J., Felkin L.E., Cullen M.E., Koban M.U., Yacoub M.H. Increased expression of extracellular matrix regulators TIMP1 and MMP1 in deteriorating heart failure. J. Heart Lung Transpl. 2003, 22:738-744.
Benjamini Y., Hochberg Y. Controlling the false discovery rate. a practical and powerful approach to multiple testing (Methodological). J. Roy. Stat. Soc. Ser. B 1995, 57:289-300.
Buchman A.S., Wilson R.S., Bienias J.L., Bennett D.A. Change in frailty and risk of death in older persons. Exp. Aging Res. 2009, 35:61-82.
Calabrese V., Cornelius C., Mancuso C., Pennisi G., Calafato S., Bellia F., Bates T.E., Giuffrida Stella A.M., Schapira T., Dinkova Kostova A.T., Rizzarelli E. Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity. Neurochem. Res. 2008, 33:2444-2471.
Cawthon R.M. Telomere measurement by quantitative PCR. Nucleic Acids Res. 2002, 30:e47.
Chandra R.K. Nutritional regulation of immunity and risk of illness. Indian J. Pediatr. 1989, 56:607-611.
Chowdhury G., Guengerich F.P. Tandem mass spectrometry-based detection of c4'-oxidized abasic sites at specific positions in DNA fragments. Chem. Res. Toxicol. 2009, 22:1310-1319.
Colotta F., Saccani S., Giri J.G., Dower S.K., Sims J.E., Introna M., Mantovani A. Regulated expression and release of the IL-1 decoy receptor in human mononuclear phagocytes. J. Immunol. 1996, 156:2534-2541.
de Saint-Hubert, M., Jamart, J., Morrhaye, G., Martens, H.J., Geenen, V., Vo, T.K., Toussaint, O., Swine, C., 2010. Serum Il-6 and IGF-1 improve the clinical prediction of functional decline after hospitalization in older patients. Aging Clin. Exp. Res. May 6. [Epub ahead of print], doi:10.3275/7028.
Debacq-Chainiaux F., Pascal T., Boilan E., Bastin C., Bauwens E., Toussaint O. Screening of senescence-associated genes with specific DNA array reveals the role of IGFBP-3 in premature senescence of human diploid fibroblasts. Free Radic. Biol. Med. 2008, 44:1817-1832.
Dierick J.F., Wenders F., Chainiaux F., Remacle J., Fisher A.B., Toussaint O. Retrovirally mediated overexpression of peroxiredoxin VI increases the survival of WI-38 human diploid fibroblasts exposed to cytotoxic doses of tert-butylhydroperoxide and UVB. Biogerontology 2003, 4:125-131.
El Yousfi M., Mercier S., Breuille D., Denis P., Papet I., Mirand P.P., Obled C. The inflammatory response to vaccination is altered in the elderly. Mech. Ageing Dev. 2005, 126:874-881.
Epel E.S., Blackburn E.H., Lin J., Dhabhar F.S., Adler N.E., Morrow J.D., Cawthon R.M. Accelerated telomere shortening in response to life stress. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:17312-17315.
Ferrucci L., Harris T.B., Guralnik J.M., Tracy R.P., Corti M.C., Cohen H.J., Penninx B., Pahor M., Wallace R., Havlik R.J. Serum IL-6 level and the development of disability in older persons. J. Am. Geriatr. Soc. 1999, 47:639-646.
Folstein M.F., Folstein S.E., McHugh P.R. " Mini-mental state" A practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 1975, 12:189-198.
Forman D.E., Rich M.W. Heart failure in the elderly. Congest Heart Fail. 2003, 9:311-321. discussion 309-310; quiz 322-313.
Gabay C., Kushner I. Acute-phase proteins and other systemic responses to inflammation. N. Engl. J. Med. 1999, 340:448-454.
Goldberg A.L., Akopian T.N., Kisselev A.F., Lee D.H., Rohrwild M. New insights into the mechanisms and importance of the proteasome in intracellular protein degradation. Biol. Chem. 1997, 378:131-140.
Gong Y., Hua Y., Keep R.F., Hoff J.T., Xi G. Intracerebral hemorrhage: effects of aging on brain edema and neurological deficits. Stroke 2004, 35:2571-2575.
Heinrich P.C., Castell J.V., Andus T. Interleukin-6 and the acute phase response. Biochem. J. 1990, 265:621-636.
Hori R., Kashiba M., Toma T., Yachie A., Goda N., Makino N., Soejima A., Nagasawa T., Nakabayashi K., Suematsu M. Gene transfection of H25A mutant heme oxygenase-1 protects cells against hydroperoxide-induced cytotoxicity. J. Biol. Chem. 2002, 277:10712-10718.
Huppert F.A., Solomou W., O'Connor S., Morgan K., Sussams P., Brayne C. Aging and lymphocyte subpopulations: whole-blood analysis of immune markers in a large population sample of healthy elderly individuals. Exp. Gerontol. 1998, 33:593-600.
Katz S., Ford A.B., Moskowitz R.W., Jackson B.A., Jaffe M.W. Studies of illness in the aged: the Index of Adl: a standardized measure of biological and psychosocial function. JAMA 1963, 185:914-919.
Kisselev A.F., Goldberg A.L. Proteasome inhibitors: from research tools to drug candidates. Chem. Biol. 2001, 8:739-758.
Lakatta E.G. Age-associated cardiovascular changes in health: impact on cardiovascular disease in older persons. Heart Fail. Rev. 2002, 7:29-49.
Laughlin G.A., Barrett-Connor E., Criqui M.H., Kritz-Silverstein D. The prospective association of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-1 levels with all cause and cardiovascular disease mortality in older adults: the Rancho Bernardo Study. J. Clin. Endocrinol. Metab. 2004, 89:114-120.
Lawton M.P., Brody E.M. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 1969, 9:179-186.
Lee Y.K., Manalo D., Liu A.Y. Heat shock response, heat shock transcription factor and cell aging. Biol. Signals 1996, 5:180-191.
Leng S., Chaves P., Koenig K., Walston J. Serum interleukin-6 and hemoglobin as physiological correlates in the geriatric syndrome of frailty: a pilot study. J. Am. Geriatr. Soc. 2002, 50:1268-1271.
Leri A., Franco S., Zacheo A., Barlucchi L., Chimenti S., Limana F., Nadal-Ginard B., Kajstura J., Anversa P., Blasco M.A. Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation. Embo J. 2003, 22:131-139.
Li Y.Y., Feldman A.M., Sun Y., McTiernan C.F. Differential expression of tissue inhibitors of metalloproteinases in the failing human heart. Circulation 1998, 98:1728-1734.
Meyers M.B., Fischer A., Sun Y.J., Lopes C.M., Rohacs T., Nakamura T.Y., Zhou Y.Y., Lee P.C., Altschuld R.A., McCune S.A., Coetzee W.A., Fishman G.I. Sorcin regulates excitation-contraction coupling in the heart. J. Biol. Chem. 2003, 278:28865-28871.
Miller M.D., Paradis C.F., Houck P.R., Mazumdar S., Stack J.A., Rifai A.H., Mulsant B., Reynolds C.F. Rating chronic medical illness burden in geropsychiatric practice and research: application of the Cumulative Illness Rating Scale. Psychiatry Res. 1992, 41:237-248.
Oh H., Wang S.C., Prahash A., Sano M., Moravec C.S., Taffet G.E., Michael L.H., Youker K.A., Entman M.L., Schneider M.D. Telomere attrition and Chk2 activation in human heart failure. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:5378-5383.
Pascal T., Debacq-Chainiaux F., Boilan E., Ninane N., Raes M., Toussaint O. Heme oxygenase-1 and interleukin-11 are overexpressed in stress-induced premature senescence of human WI-38 fibroblasts induced by tert-butylhydroperoxide and ethanol. Biogerontology 2007, 8:409-422.
Patterson T.A., Lobenhofer E.K., Fulmer-Smentek S.B., Collins P.J., Chu T.M., Bao W., Fang H., Kawasaki E.S., Hager J., Tikhonova I.R., Walker S.J., Zhang L., Hurban P., de Longueville F., Fuscoe J.C., Tong W., Shi L., Wolfinger R.D. Performance comparison of one-color and two-color platforms within the MicroArray Quality Control (MAQC) project. Nat. Biotechnol. 2006, 24:1140-1150.
Phrommintikul A., Chattipakorn N. Roles of cardiac ryanodine receptor in heart failure and sudden cardiac death. Int. J. Cardiol. 2006, 112:142-152.
Schocken D.D. Epidemiology and risk factors for heart failure in the elderly. Clin. Geriatr. Med. 2000, 16:407-418.
Shi L., Reid L.H., Jones W.D., Shippy R., Warrington J.A., Baker S.C., Collins P.J., de Longueville F., Kawasaki E.S., Lee K.Y., Luo Y., Sun Y.A., Willey J.C., Setterquist R.A., Fischer G.M., Tong W., Dragan Y.P., Dix D.J., Frueh F.W., Goodsaid F.M., Herman D., Jensen R.V., Johnson C.D., Lobenhofer E.K., Puri R.K., Schrf U., Thierry-Mieg J., Wang C., Wilson M., Wolber P.K., Zhang L., Amur S., Bao W., Barbacioru C.C., Lucas A.B., Bertholet V., Boysen C., Bromley B., Brown D., Brunner A., Canales R., Cao X.M., Cebula T.A., Chen J.J., Cheng J., Chu T.M., Chudin E., Corson J., Corton J.C., Croner L.J., Davies C., Davison T.S., Delenstarr G., Deng X., Dorris D., Eklund A.C., Fan X.H., Fang H., Fulmer-Smentek S., Fuscoe J.C., Gallagher K., Ge W., Guo L., Guo X., Hager J., Haje P.K., Han J., Han T., Harbottle H.C., Harris S.C., Hatchwell E., Hauser C.A., Hester S., Hong H., Hurban P., Jackson S.A., Ji H., Knight C.R., Kuo W.P., LeClerc J.E., Levy S., Li Q.Z., Liu C., Liu Y., Lombardi M.J., Ma Y., Magnuson S.R., Maqsodi B., McDaniel T., Mei N., Myklebost O., Ning B., Novoradovskaya N., Orr M.S., Osborn T.W., Papallo A., Patterson T.A., Perkins R.G., Peters E.H., Peterson R., Philips K.L., Pine P.S., Pusztai L., Qian F., Ren H., Rosen M., Rosenzweig B.A., Samaha R.R., Schena M., Schroth G.P., Shchegrova S., Smith D.D., Staedtler F., Su Z., Sun H., Szallasi Z., Tezak Z., Thierry-Mieg D., Thompson K.L., Tikhonova I., Turpaz Y., Vallanat B., Van C., Walker S.J., Wang S.J., Wang Y., Wolfinger R., Wong A., Wu J., Xiao C., Xie Q., Xu J., Yang W., Zhang L., Zhong S., Zong Y., Slikker W. The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements. Nat. Biotechnol. 2006, 24:1151-1161.
Smyth G.K., Yang Y.H., Speed T. Statistical issues in cDNA microarray data analysis. Methods Mol. Biol. 2003, 224:111-136.
Song B., Scheuner D., Ron D., Pennathur S., Kaufman R.J. Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. J. Clin. Invest. 2008, 118:3378-3389.
Thomas C.V., Coker M.L., Zellner J.L., Handy J.R., Crumbley A.J., Spinale F.G. Increased matrix metalloproteinase activity and selective upregulation in LV myocardium from patients with end-stage dilated cardiomyopathy. Circulation 1998, 97:1708-1715.
Vaes B., de Ruijter W., Gussekloo J., Degryse J. The accuracy of plasma natriuretic peptide levels for diagnosis of cardiac dysfunction and chronic heart failure in community-dwelling elderly: a systematic review. Age Ageing 2009, 38:655-662.
Vallejo A.N. CD28 extinction in human T cells: altered functions and the program of T-cell senescence. Immunol Rev 2005, 205:158-169.
van der Harst P., van der Steege G., de Boer R.A., Voors A.A., Hall A.S., Mulder M.J., van Gilst W.H., van Veldhuisen D.J. Telomere length of circulating leukocytes is decreased in patients with chronic heart failure. J. Am. Coll. Cardiol. 2007, 49:1459-1464.
Vasan R.S., Sullivan L.M., D'Agostino R.B., Roubenoff R., Harris T., Sawyer D.B., Levy D., Wilson P.W. Serum insulin-like growth factor I and risk for heart failure in elderly individuals without a previous myocardial infarction: the Framingham Heart Study. Ann. Intern. Med. 2003, 139:642-648.
Vo T.K., Godard P., de Saint-Hubert M., Morrhaye G., Bauwens E., Debacq-Chainiaux F., Glupczynski Y., Swine C., Geenen V., Martens H.J., Toussaint O. Transcriptomic biomarkers of human ageing in peripheral blood mononuclear cell total RNA. Exp. Gerontol. 2010, 45:188-194.
Vo T.K., Godard P., de Saint-Hubert M., Morrhaye G., Swine C., Geenen V., Martens H.J., Debacq-Chainiaux F., Toussaint O. Transcriptomic biomarkers of the response of hospitalized geriatric patients with infectious diseases. Immun. Ageing 2010, 7:9.
Vo, T.K., Godard, P., de Saint-Hubert, M., Morrhaye, G., Debacq-Chainiaux, F., Swine, C., Geenen, V., Martens, H.J., Toussaint, O., 2010c. Transcriptomic biomarkers of human ageing in peripheral blood mononuclear cell total RNA. II. Hip fracture in hospitalized geriatric patients compared to healthy aged controls. Exp. Gerontol. Nov 11, [Epub ahead of print], doi:10.1016/j.exger.2010.10.012.
Wang N., Whang I., Lee J.S., Lee J. Molecular characterization and expression analysis of a heat shock protein 90 gene from disk abalone (Haliotis discus). Mol. Biol. Rep. 2010, [Epub ahead of print], doi:10.1007/s11033-010-9972-x.
Wong M.M., Fish E.N. Chemokines: attractive mediators of the immune response. Semin. Immunol. 2003, 15:5-14.
Yaffe K., Lindquist K., Kluse M., Cawthon R., Harris T., Hsueh W.C., Simonsick E.M., Kuller L., Li R., Ayonayon H.N., Rubin S.M., Cummings S.R. Telomere length and cognitive function in community-dwelling elders: Findings from the Health ABC Study. Neurobiol Aging. 2009, [Epub ahead of print] doi:10.1016/j.neurobiolaging.2009.12.006.
Yoshie O., Imai T., Nomiyama H. Chemokines in immunity. Adv. Immunol. 2001, 78:57-110.
Zheng Y., Zha Y., Gajewski T.F. Molecular regulation of T-cell anergy. EMBO Rep. 2008, 9:50-55.