Adaptation, Physiological/*physiology; Adult; Brain/*physiology; Female; Humans; Learning/*physiology; Magnetic Resonance Imaging; Male; Motor Activity/*physiology; Motor Skills/*physiology; Neuronal Plasticity/*physiology; Sleep/physiology; Wakefulness/physiology
Abstract :
[en] This study aimed to investigate, through functional MRI (fMRI), the neuronal substrates associated with the consolidation process of two motor skills: motor sequence learning (MSL) and motor adaptation (MA). Four groups of young healthy individuals were assigned to either (i) a night/sleep condition, in which they were scanned while practicing a finger sequence learning task or an eight-target adaptation pointing task in the evening (test) and were scanned again 12 h later in the morning (retest) or (ii) a day/awake condition, in which they were scanned on the MSL or the MA tasks in the morning and were rescanned 12 h later in the evening. As expected and consistent with the behavioral results, the functional data revealed increased test-retest changes of activity in the striatum for the night/sleep group compared with the day/awake group in the MSL task. By contrast, the results of the MA task did not show any difference in test-retest activity between the night/sleep and day/awake groups. When the two MA task groups were combined, however, increased test-retest activity was found in lobule VI of the cerebellar cortex. Together, these findings highlight the presence of both functional and structural dissociations reflecting the off-line consolidation processes of MSL and MA. They suggest that MSL consolidation is sleep dependent and reflected by a differential increase of neural activity within the corticostriatal system, whereas MA consolidation necessitates either a period of daytime or sleep and is associated with increased neuronal activity within the corticocerebellar system.
Disciplines :
Radiology, nuclear medicine & imaging
Author, co-author :
Debas, K.
Carrier, J.
Orban, Patricia ; Universitéde Liège > Centre de Recherches du Cyclotron
Barakat, M.
Lungu, O.
Vandewalle, Gilles ; Université de Liège - ULiège > Centre de recherches du cyclotron
Hadj Tahar, A.
Bellec, P.
Karni, A.
Ungerleider, L. G.
Benali, H.
Doyon, J.
Language :
English
Title :
Brain plasticity related to the consolidation of motor sequence learning and motor adaptation
Publication date :
2010
Journal title :
Proceedings of the National Academy of Sciences of the United States of America
ISSN :
0027-8424
eISSN :
1091-6490
Publisher :
National Academy of Sciences, Washington, United States - District of Columbia
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