fMRI; hippocampus; Magnetic Resonance Imaging; medial prefrontal cortex; memory
Abstract :
[en] After encoding, memory traces are initially fragile and have to be reinforced to become permanent. The initial steps of this process occur at a cellular level within minutes or hours. Besides this rapid synaptic consolidation, systems consolidation occurs within a time frame of days to years. For declarative memory, the latter is presumed to rely on an interaction between different brain regions, in particular the hippocampus and the medial prefrontal cortex (mPFC). Specifically, sleep has been proposed to provide a setting that supports such systems consolidation processes, leading to a transfer and perhaps transformation of memories. Using functional MRI, we show that postlearning sleep enhances hippocampal responses during recall of word pairs 48 h after learning, indicating intrahippocampal memory processing during sleep. At the same time, sleep induces a memory-related functional connectivity between the hippocampus and the mPFC. Six months after learning, memories activated the mPFC more strongly when they were encoded before sleep, showing that sleep leads to long-lasting changes in the representation of memories on a systems level.
Disciplines :
Neurology Radiology, nuclear medicine & imaging
Author, co-author :
Gais, Steffen
Albouy, Geneviève ; Université de Liège - ULiège > Centre de recherches du cyclotron
Boly, Mélanie ; Université de Liège - ULiège > Centre de Recherches du Cyclotron > Neurologie
Dang Vu, Thien Thanh ; Université de Liège - ULiège > Centre de recherche du cyclotron
Darsaud, Annabelle ; Université de Liège - ULiège > Centre de recherche du cyclotron
Desseilles, Martin ; Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie et psychologie médicale
Rauchs, Geneviève
Schabus, Manuel ; Université de Liège - ULiège > Centre de recherche du cyclotron
Sterpenich, Virginie ; Université de Liège - ULiège > Centre de recherches du cyclotron
Vandewalle, Gilles ; Université de Liège - ULiège > Centre de recherches du cyclotron
Maquet, Pierre ; Université de Liège - ULiège > Centre de recherches du cyclotron
Peigneux, Philippe ; Université de Liège - ULiège > Centre de Recherches du Cyclotron > Département des sciences cognitives
Language :
English
Title :
Sleep transforms the cerebral trace of declarative memories
Publication date :
2007
Journal title :
Proceedings of the National Academy of Sciences of the United States of America
ISSN :
0027-8424
eISSN :
1091-6490
Publisher :
Natl Acad Sciences, Washington, United States - District of Columbia
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE] FMRE - Fondation Médicale Reine Elisabeth [BE] Erwin Schro¨dinger fellowship of the Austrian Science Fund DFG - Deutsche Forschungsgemeinschaft [DE]
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