Imiquimod-responsive basal cell carcinomas and factor XIIIa-enriched dendrocytes.

Adjuvants, Immunologic/administration & dosage; Administration, Topical; Aged; Aminoquinolines/administration & dosage; Carcinoma, Basal Cell/drug therapy/immunology; Dendritic Cells/immunology; Facial Neoplasms/drug therapy; Factor XIIIa/immunology; Humans; Immunohistochemistry; Middle Aged; Skin Neoplasms/drug therapy/immunology

Abstract :

[en] Dermal dendrocytes (DDs) are dendritic cells that exhibit immunoreactivity for factor XIIIa, and are frequently found in conjunction with basal cell carcinomas (BCCs). Imiquimod was applied to 12 superficial BCCs every 3 days for 8 weeks. One week after completion of treatment, seven lesions appeared to have resolved, while five displayed evidence of residual BCC. Prior to initiation of treatment, the seven imiquimod-responsive BCCs were surrounded by numerous DDs, whereas the five imiquimod-resistant BCCs had fewer DDs next to them at the time of entry into the study. It appears that the pretreatment density in DDs may affect the efficacy of imiquimod in eradicating skin tumours.

Disciplines :

Dermatology

Author, co-author :

Quatresooz, Pascale ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Pierard, Gérald ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Language :

English

Title :

Imiquimod-responsive basal cell carcinomas and factor XIIIa-enriched dendrocytes.

Publication date :

2003

Journal title :

Clinical and Experimental Dermatology

ISSN :

0307-6938

eISSN :

1365-2230

Publisher :

Blackwell Publishing, Oxford, United Kingdom

Volume :

28 Suppl 1

Pages :

27-9

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 12 March 2009

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Bibliography

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