[en] Canine sino-nasal aspergillosis is a common cause of chronic nasal discharge. The pathogenesis of the disease is not well understood but factors associated to the fungus and to the host are implicated. Even if computed tomography and magnetic resonance imaging have been proved valuable in differentiating sino-nasal aspergillosis from neoplasia, the definitive diagnosis of the disease requires visualisation of the fungus either by rhinoscopy, cytology or histology. The best treatment involves topical administration of antifungal drugs. The long-term prognosis is guarded to good. [fr] L’aspergillose naso-sinusale est une cause fréquente de jetage nasal chez le chien. La pathogénie de la maladie n’est pas bien comprise mais résulte de facteurs liés au champignon et à l’hôte. Même si les techniques d’imagerie en coupe (scanner ou tomodensitométrie et imagerie par résonance magnétique) sont très utiles pour différencier l’aspergillose d’une tumeur des cavités nasales, le diagnostic définitif de la maladie requiert la visualisation du champignon lors de l’examen rhinoscopique, cytologique ou histologique. Le traitement le plus efficace consiste en l’utilisation d’agents anti-fongiques par voie topique. Le pronostic de l’affection à long terme est réservé à bon.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Peeters, Dominique ; Université de Liège - ULiège > Clinique des petits animaux
Clercx, Cécile ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Pathologie médicale des petits animaux
AMITANI R., TAYLOR G., ELEZIS E.N., LLEWELLYN-JONES C., MITCHELL J., KUZE F., COLE P.J., WILSON R. Purification and characterization of factors produced by Aspergillus fumigatus which affect human ciliated respiratory epithelium. Infect. Immun., 1995, 63, 3266-3271.
BARRETT R.E., HOFFER R.E., SCHULTZ R.D. Treatment and immunological evaluation of 3 cases of canine aspergillosis. J. Am. Anim. Hosp. Assoc., 1977, 13, 328-334.
BURK R.L. Computed tomographic imaging of nasal disease in 100 dogs. Vet. Radiol. Ultrasound, 1992, 33, 177-180.
CAULKETT N., LEW L., FRIES C. Upper-airway obstruction and prolonged recovery from anesthesia following intranasal clotrimazole administration. J. Am. Anim. Hosp. Assoc., 1997, 33, 264-267.
CHAPARAS S.D., MORGAN P.A., HOLOBAUGH P., KIM S.J. Inhibition of cellular immunity by products of Aspergillus fumigatus. J. Med. Vet. Mycol., 1986, 24, 67-76.
CODNER E.C., LURUS A.G., MILLER J.B., GAVIN P.R., GALLINA A., BARBEE D.D. Comparison of computed tomography with radiography as a noninvasive diagnostic technique for chronic nasal disease in dogs. J. Am. Vet. Med. Assoc., 1993, 202, 1106-1110.
CUSUMANO V., COSTA G.B., SEMINARA S. Effect of aflatoxins on rat peritoneal macrophages. Appl. Environ. Microbiol., 1990, 56, 3482-3484.
DAVIDSON A.P., PAPPAGIANIS D. Treatment of nasal aspergillosis with topical clotrimazole. In: Kirk R., Bonagura J. (Eds.), Current veterinary therapy. WB Saunders: Philadelphia, 1995, 899-901.
DAY M.J., PENHALE W.J. An immunohistochemical study of canine disseminated aspergillosis. Aust. Vet. J., 1991, 68, 383-386.
EICHNER R.D., AL SALAMI M., WOOD P.R., MULLBACHER A. The effect of gliotoxin upon macrophage function. Int. J. Immunopharmacol., 1986, 8, 789-797.
GIBBS C., LANE J.G., DENNY H.R. Radiological features of intra-nasal lesions in the dog: A review of 100 cases. J. Small Anim. Pract., 1979, 20, 515-535.
HAMILOS D.L., LUND V.J. Etiology of chronic rhinosinusitis: The role of fungus. Ann. Otol. Rhinol. Laryngol. Suppl., 2004, 193, 27-31.
HARVEY C.E. Nasal aspergillosis and penicilliosis in dogs: Results of treatment with thiabendazole. J. Am. Vet. Med. Assoc., 1984, 184, 48-50.
KOTHARY M.H., CHASE T., JR., MACMILLAN J.D. Correlation of elastase production by some strains of Aspergillus fumigatus with ability to cause pulmonary invasive aspergillosis in mice. Infect. Immun., 1984, 43, 320-325.
LEGENDRE A., TOAL R. Diagnosis and treatment of fungal diseases of the respiratory system. In: Kirk R., Bonagura J. (Eds.), Current veterinary therapy. WB Saunders: Philadelphia, 2000, 815-819.
MATHEWS K. Fungal rhinitis. In: King L. (Ed.), Textbook of respiratory disease in dogs and cats. Saunders: St Louis, 2004, 284-293.
MATHEWS K.G., KOBLIK P.D., RICHARDSON E.F., DAVIDSON A.P., PAPPAGIANIS D. Computed tomographic assessment of noninvasive intranasal infusions in dogs with fungal rhinitis. Vet. Surg., 1996, 25, 309-319.
MATHEWS K.G., DAVIDSON A.P., KOBLIK P.D., RICHARDSON E.F., KOMTEBEDDE J., PAPPAGIANIS D., HECTOR R.F., KASS P.H. Comparison of topical administration of clotrimazole through surgically placed versus nonsurgically placed catheters for treatment of nasal aspergillosis in dogs: 60 cases (1990-1996). J. Am. Vet. Med. Assoc., 1998, 213, 501-506.
MCCULLOUGH S.M., MCKIERNAN B.C., GRODSKY B.S. Endoscopically placed tubes for administration of enilconazole for treatment of nasal aspergillosis in dogs. J. Am. Vet. Med. Assoc., 1998, 212, 67-69.
MONOD M., PARIS S., SARFATI J., JATON-OGAY K., AVE P., LATGE J.P. Virulence of alkaline protease-deficient mutants of Aspergillus fumigatus. FEMS Microbiol. Lett., 1993, 106, 39-46.
PARK R.D., BECK E.R., LECOUTEUR R.A. Comparison of computed tomography and radiography for detecting changes induced by malignant nasal neoplasia in dogs. J. Am. Vet. Med. Assoc., 1992, 201, 1720-1724.
PENALVER M.C., O'CONNOR J.E., MARTINEZ J.P., GIL M.L. Binding of human fibronectin to Aspergillus fumigatus conidia. Infect. Immun., 1996, 64, 1146-1153.
REBAR A.H., HAWKINS E.C., DENICOLA D.B. Cytologic evaluation of the respiratory tract. Vet. Clin. North Am. Small Anim. Pract., 1992, 22, 1065-1085.
SAUNDERS J.H., ZONDERLAND J.L., CLERCX C., GIELEN I., SNAPS F.R., SULLIVAN M., VANBREE H., DONDELINGER R.F. Computed tomographic findings in 35 dogs with nasal aspergillosis. Vet. Radiol. Ultrasound, 2002, 43, 5-9.
SAUNDERS J.H., VAN BREE H. Comparison of radiography and computed tomography for the diagnosis of canine nasal aspergillosis. Vet. Radiol. Ultrasound, 2003a, 44, 414-419.
SAUNDERS J.H., VAN BREE H. Diagnostic modalities of canine nasal aspergillosis. Vlaams Dier. Tijd., 2003b, 72, 399-408.
SAUNDERS J.H., VAN BREE H., GIELEN I., DE ROOSTER H. Diagnostic value of computed tomography in dogs with chronic nasal disease. Vet. Radiol. Ultrasound, 2003, 44, 409-413.
SAUNDERS J.H., CLERCX C., SNAPS F.R., SULLIVAN M., VANBREE H., DONDELINGER R.F. Radiographic, magnetic resonance, computed tomographic and rhinoscopic features of canine nasal aspergillosis. J. Am. Vet. Med. Assoc., 2004, 225, 1703-1712.
SCHUBERT M.S. Allergic fungal sinusitis: Pathogenesis and management strategies. Drugs, 2004, 64, 363-374.
SCHULLER S., CLERCX C. Long-term outcome in dogs with sinonasal aspergillosis treated with intranasal infusion of enilconazole. In: Proceedings of the 14th ECVIM Congress. Barcelona: 2004:194.
SHARP N.J., SULLIVAN M. Use of ketoconazole in the treatment of canine nasal aspergillosis. J. Am. Vet. Med. Assoc., 1989, 194, 782-786.
SHARP N.J. Canine nasal aspergillosis-penicilliosis. In: Greene C. (Ed.), Infectious diseases of the dog and the cat. WB Saunders: Philadelphia, 1998, 404-409.
SHARP N.J.H. Nasal aspergillosis. In: Kirk R. (Ed.), Current veterinary therapy. WB Saunders: Philadelphia, 1989, 1106-1109.
SHARP N.J.H., HARVEY C.E., OBRIEN J.A. Treatment of canine nasal aspergillosis penicilliosis with fluconazole (uk-49,858). J. Small Anim. Pract., 1991a, 32, 513-516.
SHARP N.J.H., HARVEY C.E., SULLIVAN M. Canine nasal aspergillosis and penicilliosis. Comp. Cont. Educ., 1991b, 13, 41.
SHARP N.J.H., SULLIVAN M., HARVEY C.E., WEBB T. Treatment of canine nasal aspergillosis with enilconazole. J. Vet. Intern. Med., 1993, 7, 40-43.
SMITH S.A., ANDREWS G., BILLER D.S. Management of nasal aspergillosis in a dog with a single, noninvasive intranasal infusion of clotrimazole. J. Am. Anim. Hosp. Assoc., 1998, 34, 487-492.
SULLIVAN M., LEE R., JAKOVLJEVIC S., SHARP N.J. The radiological features of aspergillosis of the nasal cavity and frontal sinuses in the dog. J. Small Anim. Pract., 1986, 27, 167-180.
SULLIVAN M., LEE R., SKAE C.A. The radiological features of 60 cases of intranasal neoplasia in the dog. J. Small Anim. Pract., 1987, 28, 575-586.
TASKER S., KNOTTENBELT C.M., MUNRO E.A., STONEHEWER J., SIMPSON J.W., MACKIN A.J. Aetiology and diagnosis of persistent nasal disease in the dog: A retrospective study of 42 cases. J. Small Anim. Pract., 1999, 40, 473-478.
TOMEE J.F., WIERENGA A.T., HIEMSTRA P.S., KAUFFMAN H.K. Proteases from Aspergillus fumigatus induce release of proinflammatory cytokines and cell detachment in airway epithelial cell lines. J. Infect. Dis., 1997, 176, 300-303.
TRONCHIN G., ESNAULT K., RENIER G., FILMON R., CHABASSE D., BOUCHARA J.P. Expression and identification of a laminin-binding protein in Aspergillus fumigatus conidia. Infect. Immun., 1997, 65, 9-15.
URI N., COHEN-KEREM R., ELMALAH I., DOWECK I., GREENBERG E. Classification of fungal sinusitis in immunocompetent patients. Otolaryngol. Head Neck Surg., 2003, 129, 372-378.
WINDSOR R.C., JOHNSON L.R., HERRGESELL E.J., DE COCK H.E. Idiopathic lymphoplasmacytic rhinitis in dogs: 37 cases (1997-2002). J. Am. Vet. Med. Assoc., 2004, 224, 1952-1957.
ZONDERLAND J.L., STORK C.K., SAUNDERS J.H., HAMAIDE A.J., BALLIGAND M.H., CLERCX C.M. Intranasal infusion of enilconazole for treatment of sinonasal aspergillosis in dogs. J. Am. Vet. Med. Assoc., 2002, 221, 1421-1425.
Similar publications
Sorry the service is unavailable at the moment. Please try again later.
This website uses cookies to improve user experience. Read more
Save & Close
Accept all
Decline all
Show detailsHide details
Cookie declaration
About cookies
Strictly necessary
Performance
Strictly necessary cookies allow core website functionality such as user login and account management. The website cannot be used properly without strictly necessary cookies.
This cookie is used by Cookie-Script.com service to remember visitor cookie consent preferences. It is necessary for Cookie-Script.com cookie banner to work properly.
Performance cookies are used to see how visitors use the website, eg. analytics cookies. Those cookies cannot be used to directly identify a certain visitor.
Used to store the attribution information, the referrer initially used to visit the website
Cookies are small text files that are placed on your computer by websites that you visit. Websites use cookies to help users navigate efficiently and perform certain functions. Cookies that are required for the website to operate properly are allowed to be set without your permission. All other cookies need to be approved before they can be set in the browser.
You can change your consent to cookie usage at any time on our Privacy Policy page.
