Article (Scientific journals)
Skin-lightening products revisited.
Petit, Ludivine; Pierard, Gérald
2003In International Journal of Cosmetic Science, 25 (4), p. 169-81
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Abstract :
[en] Skin colour typology depends on the amount and location of its chromophores. Among them, eumelanins derived from 5,6-dihydroxyindole-2-carboxylic acid (DHICA) and 5,6-dihydroxyindole (DHI), and phaeomelanins are of utmost importance. These biomolecules result from the multi-step enzymatic and non-enzymatic conversion of tyrosine into melanins. Pigmentation disorders are multiple and depend on alterations in the density in active melanocytes, and on specific abnormalities of any of the complex melanogenesis mechanisms. This review presents some of the main skin-lightening agents with respect to their mechanisms of action and side-effects. Some of the novel compounds may lead to new perspectives in the fields of dermatology and cosmetology. The methods commonly used to assess efficacy of skin-lightening products rely on in vitro models including cell-free enzymatic assays, melanocyte cultures and reconstructed epidermis bioassays. Animal models have little relevance. By contrast, human testing with the support of instrumental evaluations is the most informative.
Disciplines :
Dermatology
Author, co-author :
Petit, Ludivine;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Pierard, Gérald ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Language :
English
Title :
Skin-lightening products revisited.
Publication date :
2003
Journal title :
International Journal of Cosmetic Science
ISSN :
0142-5463
eISSN :
1467-2494
Publisher :
Blackwell Publishing, United Kingdom
Volume :
25
Issue :
4
Pages :
169-81
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 12 March 2009

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