[en] OBJECTIVES: The aim of this study was to investigate the relationship between medial cortical activation and the presence of self and consciousness in healthy subjects and patients with vegetative state and minimally conscious state using functional magnetic resonance imaging (fMRI). EXPERIMENT DESIGN: We first conducted two fMRI experiments in healthy subjects to identify brain regions specifically associated with self-perception through the use of different auditory stimuli that had different grades of self-relatedness. We then applied these regions as functional localizers to examine the relationship between neural activity changes during self-relatedness and consciousness level in the patients with disorders of consciousness (DOC). PRINCIPAL OBSERVATIONS: We demonstrated recruitment of various anterior medial cortical regions including the anterior cingulate cortex (ACC) in healthy subjects during auditory perception of self-related stimuli. We further showed that patients with DOC showed signal changes in the ACC during auditory perception of self-related stimuli. Finally, it was shown that these signal changes correlate with the level of consciousness in the patients with DOC. CONCLUSION: The degree of consciousness in patients with DOC was correlated with neural activity in the ACC induced by self-related stimuli. Our results not only shed light on the pathophysiology of DOC, but may also suggest a useful neural, and thus diagnostic, marker of the dysfunction of consciousness in vegetative patients.
Centre de recherche :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Neurologie
Auteur, co-auteur :
Qin, Pengmin
Di, Haibo
Liu, Yijun
Yu, Senming
Gong, Qiyong
Duncan, Niall
Weng, Xuchu
Laureys, Steven ; Université de Liège - ULiège > Coma Science Group > Centre de recherches du cyclotron - Département des sciences cliniques
Northoff, Georg
Langue du document :
Anglais
Titre :
Anterior cingulate activity and the self in disorders of consciousness.
Date de publication/diffusion :
2010
Titre du périodique :
Human Brain Mapping
ISSN :
1065-9471
eISSN :
1097-0193
Maison d'édition :
Wiley Liss, Inc., New York, Etats-Unis - New York
Volume/Tome :
31
Fascicule/Saison :
12
Pagination :
1993-2002
Peer reviewed :
Peer reviewed vérifié par ORBi
Organisme subsidiant :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
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