Reference : Antibodies to laminin in Chagas' disease
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Antibodies to laminin in Chagas' disease
Szarfman, A. [ > > ]
Terranova, V. P. [ > > ]
Rennard, S. I. [ > > ]
Foidart, Jean-Michel mailto [Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement >]
de Fatima Lima, M. [ > > ]
Scheinman, J. L. [ > > ]
Martin, G. R. [ > > ]
Journal of Experimental Medicine
Rockefeller University Press
Yes (verified by ORBi)
New York
[en] We have found that sera from humans with Chagas' disease and Rhesus monkeys infected with Trypanosoma cruzi contain IgM and IgG antibodies, which react with structures in a variety of connective tissues. These antibodies react with laminin but not with various other purified connective tissue components like collagen types I, III, IV, and V, fibronectin, heparan sulfate (BM-1) proteoglycan, or chondronectin. The tissue-reacting antibodies were isolated by absorption to a laminin-Sepharose column. The bound fraction contained all the tissue-reacting antibodies. These antibodies strongly stained trypomastigotes and amastigotes, but weakly stained epimastigotes. These studies show that sera from T. cruzi-infected primates contain antilaminin antibodies, which may be produced by those host in response to a laminin-like molecule present in the parasite.

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