Nudging epidermal field cancerogenesis by imiquimod.

Administration, Topical; Aged; Aminoquinolines/therapeutic use; Antineoplastic Agents/therapeutic use; Biopsy; Bowen's Disease/drug therapy/pathology; Carcinoma, Basal Cell/drug therapy/pathology; Humans; Keratinocytes/drug effects; Middle Aged; Neoplasms, Multiple Primary/drug therapy/pathology; Skin/pathology; Skin Neoplasms/drug therapy/pathology; Treatment Outcome

Abstract :

[en] BACKGROUND: The coexistence of malignancies close to each other on the skin has been occasionally reported. The concept of field cancerogenesis applies to such cases. Given the purported mechanism of action of imiquimod, it should not be surprising that this treatment could inhibit epidermal field cancerogenesis. AIM: To assess the effect of imiquimod applied twice weekly on incipient bowenoid changes disclosed in the vicinity of basal cell carcinomas. MATERIALS AND METHOD: Biopsies were taken before treatment and after 4-6 weeks and 12 weeks of imiquimod treatment. RESULTS: Large atypical bowenoid keratinocytes and dyskeratotic cells were cleared in time while factor-XIIIa-positive dermal dendrocytes appeared boosted and admixed with a brisk lymphocytic infiltration. CONCLUSION: Epidermal field cancerogenesis appears to be controlled by imiquimod. Dermal dendrocytes might play a pivotal role in this regression phenomenon.

Disciplines :

Dermatology

Author, co-author :

Uhoda, Isabelle; Centre Hospitalier Régional de Huy > Dermatologie

Quatresooz, Pascale ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Pierard, Claudine ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Pierard, Gérald ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Language :

English

Title :

Nudging epidermal field cancerogenesis by imiquimod.

Publication date :

2003

Journal title :

Dermatology

ISSN :

1018-8665

eISSN :

1421-9832

Publisher :

S. Karger, Basel, Switzerland

Volume :

206

Issue :

Pages :

357-60

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 11 March 2009

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