Article (Scientific journals)
Effects of chronic obesity and weight loss on plasma ghrelin and leptin concentrations in dogs.
Jeusette, Isabelle C; Detilleux, Johann; Shibata, Haruki et al.
2005In Research in Veterinary Science, 79 (2), p. 169-75
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Keywords :
Animals; Blood Glucose; Dog Diseases/blood/physiopathology; Dogs; Female; Ghrelin; Insulin/blood; Leptin/blood; Male; Obesity/blood/physiopathology/veterinary; Peptide Hormones/blood; Weight Loss/physiology
Abstract :
[en] The objective of this study was to evaluate, in dogs, the effects of obesity and weight loss on plasma total ghrelin and leptin concentrations. Twenty-four Beagle dogs, 12 control lean and 12 obese dogs of both genders and aged between 1 and 9 years, were used for the experiments. Mean body weight was 12.7+/-0.7 kg for the lean group and 21.9+/-0.8 kg for the obese group. The trial was divided into three phases. During phase 1, all 24 Beagle dogs were fed a maintenance diet. During phase 2, the obese dogs were submitted to a weight loss protocol with a high protein-low energy diet. The weight loss protocol ended once dogs reached optimal body weight. During phase 3, the dogs that were submitted to the weight loss protocol were maintained at their optimal body weight for 6 months. Plasma total ghrelin, leptin, insulin and glucose concentrations were measured to evaluate the effects of obesity and weight loss on these parameters in dogs. Body weight, body condition score, thoracic and pelvic perimeters, and ingested food amounts were also recorded during the study. Obese dogs demonstrated a significant decrease in plasma ghrelin and a significant increase in plasma leptin and insulin concentrations when compared with control dogs. During weight loss, significant increases in plasma total ghrelin and glucose and significant decreases in plasma leptin and insulin were observed. The increase in plasma ghrelin concentrations seemed to be transient. Body weight and the morphometric parameters correlated positively with leptin concentrations and negatively with total ghrelin concentrations. These results suggest that ghrelin and leptin could play a role in dogs in the adaptation to a positive or negative energy balance, as observed in humans.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Jeusette, Isabelle C
Detilleux, Johann ;  Université de Liège - ULiège > Département de productions animales > Génétique quantitative - Epidémiologie et santé publique
Shibata, Haruki
Saito, Masayuki
Honjoh, Tsutomu
Delobel, Agathe
Istasse, Louis ;  Université de Liège - ULiège > Département de productions animales > Nutrition des animaux domestiques
Diez, Marianne ;  Université de Liège - ULiège > Département de productions animales > Nutrition des animaux domestiques
Language :
English
Title :
Effects of chronic obesity and weight loss on plasma ghrelin and leptin concentrations in dogs.
Publication date :
2005
Journal title :
Research in Veterinary Science
ISSN :
0034-5288
eISSN :
1532-2661
Publisher :
British Veterinary Association, London, United Kingdom
Volume :
79
Issue :
2
Pages :
169-75
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
ULiège - Université de Liège [BE]
Available on ORBi :
since 11 March 2009

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