Increased Sister Chromatid Exchange Frequencies Observed in a Cohort of Inhabitants of a Village Located at the Boundary of an Industrial Dumping Ground: Phase I
Laurent, C.; Lakhanisky, T.; Jadot, P.et al.
1993 • In Cancer Epidemiology, Biomarkers and Prevention, 2 (4, Jul-Aug), p. 355-62
[en] Since the mid-eighties, a sand pit located at the boundary of Mellery, a small village in Belgium, has been used as a dumping ground for industrial waste. After a particularly dry summer, many people complained of very foul smells coming from the dumping ground. An analysis of the environmental atmosphere detected alkanes and chlorinated saturated and unsaturated hydrocarbons in various concentrations. Consequently, the Belgian Ministry of the Environment requested additional measurements from the dumping site and the surrounding regions. Given the hazards and possible ill health effects associated with simultaneous exposure to low levels of many chemicals, biomarkers of personal exposure were measured in a representative group of people living in this village. The cytogenetic consequences of daily exposure to a mixture of genotoxicants were measured by the Sister Chromatid Exchange assay. The study included a group of 51 environmentally exposed persons (including 11 children) and 52 controls. A significant increase in Sister Chromatid Exchange frequency was detected among the inhabitants of the village compared to that of the control group, especially among the children living in Mellery as compared to the matched control children.
Disciplines :
Biochimie, biophysique & biologie moléculaire
Auteur, co-auteur :
Laurent, C.
Lakhanisky, T.
Jadot, P.
Joris, I.
Ottogali, M.
Planard, C.
Bazzoni, D.
Foidart, Jean-Michel ; Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement
Ros, Y.
Langue du document :
Anglais
Titre :
Increased Sister Chromatid Exchange Frequencies Observed in a Cohort of Inhabitants of a Village Located at the Boundary of an Industrial Dumping Ground: Phase I
Date de publication/diffusion :
1993
Titre du périodique :
Cancer Epidemiology, Biomarkers and Prevention
ISSN :
1055-9965
eISSN :
1538-7755
Maison d'édition :
American Association for Cancer Research, Inc. (AACR), Birmingham, Etats-Unis - Alabama
Carrano, A. V., and D. H. Moore. The rationale and methodology for quantifying sister chromatid exchanges in human. In: D. E. Buetow, I. L. Cameron, G. M. Padilla, and A. M. Zimmerman (eds.), Mutagenicity: New Horizons in Genetic Toxicology, pp. 268–299. New York: Academic Press, 1982.
Carrano, A. V. SCE as an indicator of human exposure. In: B. A. Bridges (ed), Bandbury Report 13: Indicators of Genotoxic Exposure, pp. 307–318. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory, 1982.
Sorsa, M. Monitoring of sister chromatid exchanges and micronuclei as biological endpoints. In: A. Berlin, N. Draper, K. Hemminki, and H. Vainio, (eds.), Monitoring Human Exposure to Carinogenic and Mutagenic Agents, 339–349. IARC Scientific Pub. No. 59. Lyon, France: International Agency for Research on Cancer, 1984.
Laurent, C. Les Échanges entre Chromatides-Soeurs (SCEs), Test de Mutagenèse Appliqué en Médecine Préventive et dans le Domaine de la Santé Publique (thesis). University of Liège, Belgium, Faculty of Medicine. Thèse de Doctorat en Sciences Biomédicales Expérimentales, 1986.
Carrano, A. V., and Natarajan, A. T. Considerations for population monitoring using cytogenetic techniques. Mutat. Res., 3: 379–407, 1988.
Laurent, C. Application of the sister chromatid exchanges methodology for biomonitoring human exposed to environmental mutagens. In: C. Maiam led.), Environmental Mutagens, Carcinogens and Teratogens: Principles and Short Term Assay, pp. 246–273. Star Press, 1991.
Ciccioli, P., Bertoni, C., Brancaleoni, E., Fratarcangeli, R., and Bruner, F. Evaluation of organic polluants in the open air of the atmospheres and industrial sites using graphitized carbon black traps and gas chromatographic-mass spectrometric analysis with specific detectors. Chromatography, 126: 757–770, 1976.
Hutte, R. S., Williams, E. I., Staehelin, I., Hawthorne, S. B., Barkley, R. M., and Sievers, R. E. Chromatographic analysis of organic compounds in the atmosphere. I. Chromatog., 302: 173–179, 1984.
Perry, P., and Wolff, S. New Giemsa method for the differential stainingofsisterchromatids. Nature (Lond.), 251: 156–158, 1974.
Laurent, C., Frederic, I., and Leonard, A. Y. Sister chromatid exchanges frequency in workers exposed to high levels of ethylene oxide, in a hospital sterilization service. Int. Archrttccup. Environ. Health, 54: 33–43, 1984.
Gu, Z. W., Sèle, B., and Chmara, D. Effets du trichloréthyléne et ses métabolites sur le taux d’échanges entre chromatides-soeurs. Ann. Genet., 36: 276–280, 1981.
Knuutila, S., and Mäki, J. An increased frequency ot chromosomal changes and SCEs in culture blood lymphocytes of 12 subjects vaccinated against smallpox. Hum. Genet., 41: 89–96, 1978.
Kelsey, K. T., Christiani, D. C., and Wiencke, I. K. Bimodal distribution of sensitivity to SCE induction by diepoxybutane in human lymphocytes. II relationship to baseline SCEs frequency. Mutat. Res., 248: 27–33, 1991.
Wauters, E., Lenelle, Y., Verduyn, C., and Thiers, C. Pollution de l’air venant de la décharge des “Sablières réunies” à Mellery. Institute of Hygiene and Epidemiology Report: Section Air, pp. 1–18, 1991.
Lambert, B., and Lindblad, A. Increased frequency of sister chromatid exchanges in cigarette smokers. Hereditas, 88: 147–149, 1978.
Bala, Krishna, Murthy, and Prema. Frequency of sister chromatid exchange in cigarette smokers. Hum. Genet., 52: 343–348, 1979.
Lambert, B., Lindblad, A., Holmberg, K., and Francesconi, D. In: S. Wolf (ed.), Sister Chromatid Exchange, pp. 149–182. New York: John Wiley and Sons, 1982.
Sarto, S., Faccioli, M. C., Cominato, I., and Levis, A. C. Aging and smoking increase the frequency of sister chromatid exchanges in man. Mutat. Res., 144: 183–187, 1985.
Sarto, F., Mustari, L., Mazzotti, D., Tomanin, R., and Levis, A. G. Variations of SCEs frequencies of ex-smokers. Mutat. Res., 192: 157–162, 1987.
Hollander, D. H., Tockman, S. M., Liang, Y. V., Borgaonkar, D. S., and Frost, I. K. SCE in the peripheral blood oI cigarette smokers and in lung cancer patients and the effect of chemotherapy. Hum. Genet., 44: 165–168, 1978.
Carry, V. F., Hozier, J., lacobs, D., Wade, R. L., and Gray, D. G. Ethylene oxide: evidence of human chromosomal effects. Environ. Mutagen., 1: 375–382, 1979.
Hedner, K., Hogstedt, B., Kolnig, A. M., Vendel, M., Strombeek, B., and Mittelman, F. SCE and chromosome aberrations in relation to smoking in 91 individuals. Hereditas, 98: 77–81, 1983.
Laurent, C. SCE increases after an accidental acute inhalation exposure to Eto and recovery to normal after 2 years. Mutat. Res., 204: 711–717, 1988.
Livingston, G. K., Cannon, L. A., Bishop, U. T., Jhonson, P., and Fineman, R. M. Sister chromatid exchange: variation by age. sex, smoking and breast cancer status. Cancer Genet. Cytogenet., 9: 289–299, 1983.
Husum, B., Wulf, H. C., and Niebuhr, E. Sister chromatid exchange frequency correlates with age, sex and cigarette smoking in a 5-year material of 553 healthy adults. Hereditas, 105: 17–21, 1986.
WuIf, H. C., Kousgaard, N., and Niebuhr, E. Sister chromatid exchange in childhood in relation to age and sex. Mutat. Res., 174: 309–312, 1986.
Bender, M. A., Preston, R. I., Leonard, B. E., Pyatt, B. E., Gooch, P. C., and Shelby, M. D. Chromosomal aberrations and sister chromatid exchange frequencies in peripheral blood lymphocytes of a large human population sample. Mutat. Res., 204: 421–433, 1988.
Laurent, C. A sensitive approach for biomonitoring human exposed to mutagens: the sister chromatid exchanges methodology. Ziekenhuis Farmacie, 5: 147–152, 1989.
Hsu, T. C., Spitz, M. R., and Schantz, S. P. Mutagen sensitivity: a biological marker of cancer susceptibility. Cancer Epidemiol., Biomarkers & Prey., 1: 83–89, 1991.
Bender, M. A., and Setlow, R. B. Variation in cytogenetic response of lymphocytes from a normal human population to challenge with various mutagens. Banff, Canada: Proceedings of the American Association on Cancer Research Special Conference: Cellular Response to Environmental DNA Damage, 1991.
Albertini, R. J. The emerging picture of somatic mutations in human. Banff, Canada: Proceedings of the American Association on Cancer Research Special Conference: Cellular Response to Environmental DNA Damage, 1991.
Brögger, A., Hagmar, L., Hansteen, I., Heim, S., Hogstedt, B., Knudsen, L., Lambert, B., Linnainmaa, K., Mitelman, F., Nordensen, I., Reuterwall, C., Salomaa, S., Skerfving, S., and Sorsa, M. An inter-Nordic prospective study on cytogenetic endpoints and cancer risk. Cancer Genet. Cytogenet., 45: 85–92, 1990.
