[en] The influence of somatic growth and genetic selection on the whole blood oxygen equilibrium curve (OEC) was measured under standard conditions in double-muscled and dairy calves during their first 3 mo of life. Crossbreed animals were also investigated. Hemoglobin, 2,3-diphosphoglycerate (DPG), Cl, and Pi concentrations were also measured. The percentage of fetal hemoglobin (HbF) was determined. The influence of exogenous Cl, Pi, and pH on the OEC was also assessed. The PO2 at 50% hemoglobin saturation (P50) increased during somatic growth, probably because of the increase in DPG recorded in double-muscled neonates and to the progressive disappearance of HbF in both breeds. The oxygen exchange fraction (OEF%) was used to assess the combined influence of the OEC shift and OEC shape changes on blood oxygen desaturation under standard conditions, when the PO2 decreases within a physiological range. The OEF% showed an increase during the first month, then a stabilization. The effects of Cl, Pi, and pH in Friesian calves were similar as in adult cattle. Double-muscled neonates had a lower P50, OEF% values, and DPG concentrations and higher hemoglobin and Cl concentrations than Friesian neonates. The Pi concentration and the percentage of HbF were similar in both breeds. The pH and the Cl concentration had significantly less effect on the OEC in double-muscled than in Friesian calves. Crossbreed animals exhibited intermediate parameter values, between those recorded for double-muscled and Friesian calves. All differences between breeds progressively disappeared during the first month. These data show that blood function changes markedly in calves during the first month of life and that genetic selection can alter blood function.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Gustin, Pascal ; Université de Liège - ULiège > Département de sciences fonctionnelles > Pharmacologie, pharmacothérapie et toxicologie
Lessire, Françoise ; Université de Liège - ULiège > Département clinique des animaux de production (DCP) > Médecine interne des équidés, des ruminants et des porcs
Cambier, Carole ; Université de Liège - ULiège > Département de sciences fonctionnelles > Département de sciences fonctionnelles
Katz, V.
Ansay, Michel ; Université de Liège - ULiège > Services généraux (Faculté de médecine vétérinaire) > Relations académiques et scientifiques (Méd. vétérinaire)
Frans, A.
Clerbaux, T.
Language :
English
Title :
Influence of Age and Breed on the Binding of Oxygen to Red Blood Cells of Bovine Calves
Publication date :
1997
Journal title :
Journal of Applied Physiology
ISSN :
8750-7587
eISSN :
1522-1601
Publisher :
American Physiological Society, United States - Maryland
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
Bibliography
Amiconi, G., E. Antonini, M. Brunori, J. Wyman, and L. Zolla. Interaction of hemoglobin with salts: effects on the functional properties of human hemoglobin. J. Mol. Biol. 152: 111-129, 1981.
Bard, H., J. C. Fouron, A. M. Grothe, M. A. Soukini, and A. Cornet. The adaptation of the fetal red blood cells of newborn lambs to extrauterine life: the role of 2,3-diphosphoglycerate and adult hemoglobin. Pediatr. Res. 10: 823-825, 1976.
Bard, H., J. C. Fouron, J. E. Robillard, A. Cornet, and M. A. Soukini. Red cell oxygen affinity in fetal sheep: role of 2,3-DPG and adult hemoglobin. J. Appl. Physiol. 45: 7-10, 1978.
Breepoel, P. M. Proton Binding Studies on Hemoglobin of Cows and Eel and the Interaction With Organic Phosphates (PhD thesis). Nijmegen, Holland: University of Nijmegen, 1978.
Breepoel, P. M., F. Kreuzer, and M. Hazevoet. Interaction of organic phosphates with bovine hemoglobin I. Oxylabile and phosphate-labile proton binding. Pflügers Arch. 389: 219-225, 1981.
Breepoel, P. M., F. Kreuzer, and M. Hazevoet. Interaction of organic phosphates with bovine hemoglobin II. Oxygen binding equilibria of newborn and adult hemoglobin. Pflügers Arch. 389: 227-235, 1981.
Clerbaux, T., R. Fesler, and J. Bourgeois. A dynamic method for continuous recording of the whole blood oxyhemoglobin dissociation curve at constant temperature, pH, and PCO2. Med. Lab. Technol. 30: 1-9, 1973.
Clerbaux, T., P. Gustin, B. Detry, M. L. Cao, and A. Frans. Comparative study of the oxyhaemoglobin dissociation curve of four mammals: man, dog, horse and cattle. Comp. Biochem. Physiol. A Physiol. 106: 687-694, 1993.
Dawson, R. B., T. J. Ellis, C. E. Swiggins, and D. W. Spurlok. The function of human hemoglobin; salts effects. Vox Sang. 20: 388-396, 1971.
Fesler, R., T. Clerbaux, and L. Brasseur. A microcomputerized oxyhemoglobin dissociation curve analyzer for clinical use. Comput. Cardiol. IEEE 79-87724: 379-382, 1979.
Fronticelli, C., E. Bucci, and C. Orth. Solvent regulation of oxygen affinity in hemoglobin. Sensitivity of bovine hemoglobin to chloride ions. J. Biol. Chem. 259: 10841-10844, 1984.
Gustin, P. Spécificités Fonctionnelles du Système Respiratoire des Bovins Hyperviandeux (PhD thesis). Liège, Belgium: Université de Liège, 1989.
Gustin, P., M. Bakima, T. Art, P. Lekeux, and F. Lomba. Pulmonary function values and growth in Belgian White and Blue double-muscled cattle. Res. Vet. Sci. 45: 405-410, 1988.
Gustin, P., T. Clerbaux, E. Willems, P. Lekeux, F. Lomba, and A. Frans. Oxygen transport properties of blood in two different bovine breeds. Comp. Biochem. Physiol. A Physiol. 89: 553-558, 1988.
Gustin, P., B. Detry, M. L. Cao, F. Chenut, A. Robert, M. Ansay, A. Frans, and T. Clerbaux. Chloride and inorganic phosphate modulate binding of oxygen to bovine red blood cells. J. Appl. Physiol. 77: 202-208, 1994.
Gustin, P., A. Dhem, F. Lomba, and P. Lekeux. Cardiopulmonary function values in double-muscled cattle during muscular exercise. Vet. Res. Commun. 12: 407-416, 1988.
Hubbert, W. T., and W. J. Miller. Developmental polymorphisn in bovine hemoglobin. Am. J. Vet. Res. 32: 1723-1730, 1971.
Lee, C. K., G. V. Odell, F. P. Eliot, I. L. Anderson, and E. W. Jones. Postnatal loss of bovine fetal hemoglobin. Am. J. Vet. Res. 32: 1039-1044, 1971.
McGillivray, S. R., G. P. Searcy, and V. M. Hirsch. Serum iron, total iron binding capacity, plasma copper and hemoglobin types in anemic and poikilocytic calves. Can. J. Comp. Med. 49: 286-290, 1985.
Smith, R. C., G. J. Garbutt, R. E. Isaacks, and D. R. Harkness. Oxygen binding of fetal and adult bovine hemoglobin in the presence of organic phosphates and uric acid riboside. Hemoglobin 3: 47-55, 1979.
Tisdall, M., and J. P. Crowley. The pattern of disappearance of foetal haemoglobin in young calves. Res. Vet. Sci. 12: 583-584, 1971.
Yoder, R. D., A. Seidenfeld, W. Lopez, and K. Suwa. Measurement of oxyhemoglobin dissociation curves with computational data reductions. Comput. Biomed. Res. 6: 14-26, 1973.
Zinkl, J., and J. J. Kaneko. Erythrocytic enzymes and glycolytic intermediates in the normal bovine and in bovine erythrocytic porphyria. Comp. Biochem. Physiol. A Physiol. 45: 693-704, 1973.
Similar publications
Sorry the service is unavailable at the moment. Please try again later.
This website uses cookies to improve user experience. Read more
Save & Close
Accept all
Decline all
Show detailsHide details
Cookie declaration
About cookies
Strictly necessary
Performance
Strictly necessary cookies allow core website functionality such as user login and account management. The website cannot be used properly without strictly necessary cookies.
This cookie is used by Cookie-Script.com service to remember visitor cookie consent preferences. It is necessary for Cookie-Script.com cookie banner to work properly.
Performance cookies are used to see how visitors use the website, eg. analytics cookies. Those cookies cannot be used to directly identify a certain visitor.
Used to store the attribution information, the referrer initially used to visit the website
Cookies are small text files that are placed on your computer by websites that you visit. Websites use cookies to help users navigate efficiently and perform certain functions. Cookies that are required for the website to operate properly are allowed to be set without your permission. All other cookies need to be approved before they can be set in the browser.
You can change your consent to cookie usage at any time on our Privacy Policy page.