Increased risk of non-Hodgkin lymphoma and serum organochlorine concentrations among neighbors of a municipal solid waste incinerator

Viel, Jean-François; Floret, Nathalie; Deconinck, Eric; Focant, Jean-François; De Pauw, Edwin; Cahn, Jean-Yves

doi:10.1016/j.envint.2010.11.009

Article (Scientific journals)

Increased risk of non-Hodgkin lymphoma and serum organochlorine concentrations among neighbors of a municipal solid waste incinerator

Viel, Jean-François; Floret, Nathalie; Deconinck, Eric et al.

2011 • In Environment International, 37 (2), p. 449-453

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/82655

DOI
10.1016/j.envint.2010.11.009

PubMed
21167603

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Keywords :

Dioxin; Municipal solid waste incinerator; Non-Hodgkin lymphoma; Organochlorines; Polychlorinated biphenyls

Abstract :

[en] Organochlorine chemicals may contribute to an increased risk of non-Hodgkin lymphoma (NHL) within nonoccupationally exposed populations. Among these chemicals, dioxins and furans were mainly released by municipal solid waste incinerators (MSWIs) until a recent past in France, a source of exposure that is of public concern. We investigated organochlorines and the risk of NHL among neighbors of a French MSWI with high levels of dioxin emissions (Besançon, France), using serum concentrations to assess exposure. The study area consisted of three electoral wards, containing or surrounding the MSWI. Pesticides, dioxins, furans, and polychlorinated biphenyls (PCBs) were measured in the serum of 34 newly diagnosed NHL cases (2003– 2005) and 34 controls. Risks of NHL associated with each lipid-corrected serum concentration were estimated using exact logistic regression. The pesticides β-hexachlorocyclohexane (odds ratio [OR]=1.05, 95% confidence interval [CI]=1.00–1.12, per 10 ng/g lipid) and p,p' dichloro-diphenyl-trichloroethane (DDT) (OR=1.20, 95% CI=1.01-1.45, per 10 ng/g lipid) were associated with NHL risk. Evidence indicated an increased NHL risk associated with cumulative WHO1998-toxic equivalency factor (TEQ) concentrations (dioxins, OR=1.12, 95% CI=1.03–1.26; furans, OR=1.16, 95% CI=1.03–1.35; dioxin-like PCBs, OR=1.04, 95% CI=1.00–1.07; and total TEQ, OR=1.04, 95% CI=1.01–1.05), as well as with non dioxin-like PCBs (OR=1.02, 95% CI=1.01–1.05, per 10 ng/g lipid). Most congener-specific associations were statistically significant. This study provides strong and consistent support for an association between serum cumulative WHO1998-TEQ concentrations, at levels experienced by people residing in the vicinity of a polluting MSWI, and risk of NHL.

Research Center/Unit :

CART - Centre Interfacultaire d'Analyse des Résidus en Traces - ULiège

Disciplines :

Chemistry
Public health, health care sciences & services

Author, co-author :

Viel, Jean-François

Floret, Nathalie

Deconinck, Eric

Focant, Jean-François ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie analytique, organique et biologique

De Pauw, Edwin ; Université de Liège - ULiège > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.)

Cahn, Jean-Yves

Language :

English

Title :

Increased risk of non-Hodgkin lymphoma and serum organochlorine concentrations among neighbors of a municipal solid waste incinerator

Publication date :

February 2011

Journal title :

Environment International

ISSN :

0160-4120

eISSN :

1873-6750

Publisher :

Pergamon, Tarrytown, United States - New York

Volume :

Issue :

Pages :

449-453

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 21 January 2011

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