Dioxin; Municipal solid waste incinerator; Non-Hodgkin lymphoma; Organochlorines; Polychlorinated biphenyls
Abstract :
[en] Organochlorine chemicals may contribute to an increased risk of non-Hodgkin lymphoma (NHL) within nonoccupationally
exposed populations. Among these chemicals, dioxins and furans were mainly released by
municipal solid waste incinerators (MSWIs) until a recent past in France, a source of exposure that is of public
concern. We investigated organochlorines and the risk of NHL among neighbors of a French MSWI with high
levels of dioxin emissions (Besançon, France), using serum concentrations to assess exposure. The study area
consisted of three electoral wards, containing or surrounding the MSWI. Pesticides, dioxins, furans, and
polychlorinated biphenyls (PCBs) were measured in the serum of 34 newly diagnosed NHL cases (2003–
2005) and 34 controls. Risks of NHL associated with each lipid-corrected serum concentration were estimated
using exact logistic regression. The pesticides β-hexachlorocyclohexane (odds ratio [OR]=1.05, 95%
confidence interval [CI]=1.00–1.12, per 10 ng/g lipid) and p,p' dichloro-diphenyl-trichloroethane (DDT)
(OR=1.20, 95% CI=1.01-1.45, per 10 ng/g lipid) were associated with NHL risk. Evidence indicated an
increased NHL risk associated with cumulative WHO1998-toxic equivalency factor (TEQ) concentrations
(dioxins, OR=1.12, 95% CI=1.03–1.26; furans, OR=1.16, 95% CI=1.03–1.35; dioxin-like PCBs, OR=1.04,
95% CI=1.00–1.07; and total TEQ, OR=1.04, 95% CI=1.01–1.05), as well as with non dioxin-like PCBs
(OR=1.02, 95% CI=1.01–1.05, per 10 ng/g lipid). Most congener-specific associations were statistically
significant. This study provides strong and consistent support for an association between serum cumulative
WHO1998-TEQ concentrations, at levels experienced by people residing in the vicinity of a polluting MSWI, and
risk of NHL.
Research Center/Unit :
CART - Centre Interfacultaire d'Analyse des Résidus en Traces - ULiège
Disciplines :
Chemistry Public health, health care sciences & services
Author, co-author :
Viel, Jean-François
Floret, Nathalie
Deconinck, Eric
Focant, Jean-François ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie analytique, organique et biologique
De Pauw, Edwin ; Université de Liège - ULiège > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.)
Cahn, Jean-Yves
Language :
English
Title :
Increased risk of non-Hodgkin lymphoma and serum organochlorine concentrations among neighbors of a municipal solid waste incinerator
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Bibliography
Agopian J., Navarro J.M., Gac A.C., Lecluse Y., Briand M., Grenot P., et al. Agricultural pesticide exposure and the molecular connection to lymphomagenesis. J Exp Med 2009, 206:1473-1483.
Alexander D.D., Mink P.J., Adami H.O., Chang E.T., Cole P., Mandel J.S., et al. The non-Hodgkin lymphomas: A review of the epidemiologic literature. Int J Cancer 2007, 120(Suppl 12):1-39.
Baan R., Grosse Y., Strai K., Secretan S., El Ghissassi F., Bouvard V., et al. A review of human carcinogens-Part F: Chemical agents and related occupations. Lancet Oncol 2009, 10:1143-1144.
Baccarelli A., Hirt C., Pesatori A.C., Consonni D., Patterson D.G., Bertazzi P.A., et al. T(14;18) translocations in lymphocytes of healthy dioxin-exposed individuals from Seveso, Italy. Carcinogenesis 2006, 27:2001-2007.
Baris D., Kwak L.W., Rothman N., Wilson W., Manns A., Tarone R.E., et al. Blood levels of organochlorines before and after chemotherapy among non-Hodgkin's lymphoma patients. Cancer Epidemiol Biomark Prev 2000, 9:193-197.
Baris D., Zahm S.H. Epidemiology of lymphomas. Curr Opin Oncol 2000, 12:383-394.
Becher H., Flesch-Janys D., Kauppinen T., Kogevinas M., Steindorf K., Manz A., et al. Cancer mortality in German male workers exposed to phenoxy herbicides and dioxins. Cancer Causes Control 1996, 17:312-321.
Bertrand K.A., Spiegelman D., Aster J.C., Altshul L.M., Korrick S.A., Rodig S.J., et al. Plasma organochlorine levels and risk of non-Hodgkin lymphoma in a cohort of men. Epidemiology 2010, 21:172-180.
Bodner K.M., Collins J.J., Bloemen L.J., Carson M. Cancer risk for chemical workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Occup Environ Med 2003, 60:672-675.
Cantor K.P., Strickland P.T., Brock J.W., Bush D., Helzlsouer K., Needham L.L., et al. Risk of non-Hodgkin's lymphoma and prediagnostic serum organochlorines: β-hexachlorocyclohexane, chlordane/heptachlor-related compounds, dieldrin, and hexachlorobenzene. Environ Health Perspect 2003, 111:179-183.
Chiu B.C., Dave B.J., Blair A., Gapstur S.M., Zahm S.H., Weisenburger D.D. Agricultural pesticide use and risk of t(14;18)-defined subtypes of non-Hodgkin lymphoma. Blood 2006, 108:1363-1369.
Cocco P., Brennan P., Ibba A., de Sanjosé Llongueras S., Maynadié M., Nieters A., et al. Plasma polychlorobiphenyl and organochlorine pesticide level and risk of major lymphoma subtypes. Occup Environ Med 2008, 65:132-140.
Consonni D., Pesatori A.C., Zocchetti C., Sindaco R., D'Oro L.C., Rubagotti M., et al. Mortality in a population exposed to dioxin after the Seveso, Italy, accident in 1976: 25years of follow-up. Am J Epidemiol 2008, 167:847-858.
De Roos A.J., Hartge P., Lubin J.H., Colt J.S., Davis S., Cerhan J.R., et al. Persistent organochlorine chemicals in plasma and the risk of non-Hodgkin's lymphoma. Cancer Res 2005, 65:11214-11226.
Dich J., Zahm S.H., Hanberg A., Adami H.O. Pesticides and cancer. Cancer Causes Control 1997, 8:420-443.
Engel L.S., Laden F., Andersen A., Strickland P.T., Blair A., Needham L.L., et al. Polychlorinated biphenyl levels in peripheral blood and non-Hodgkin's lymphoma: a report from three cohorts. Cancer Res 2007, 67:5545-5552.
Fisher S.G., Fisher R.I. The epidemiology of non-Hodgkin's lymphoma. Oncogene 2004, 23:6524-6534.
Floret N., Mauny F., Challier B., Arveux P., Cahn J.Y., Viel J.F. Dioxin emissions from a solid waste incinerator and risk of non-Hodgkin lymphoma. Epidemiology 2003, 14:392-398.
Focant J.F., Eppe G., Massart A.C., Scholl G., Pirard C., De Pauw E. High-throughput biomonitoring of dioxins and polychlorinated biphenyls at the sub-picogram level in human serum. J Chromatogr A 2006, 1130:97-107.
Frery N., Zeghnoun A., Sarter H., Falq G., Pascal M., Bérat B., et al. National study on serum dioxins and PCB levels among people living around municipal solid waste incinerators 2009, French Institute for Public Health Surveillance, Saint Maurice, France, [accessed 21 September 2010]. http://www.invs.sante.fr/publications/2009/impregnation_dioxines_uiom/impregnation_dioxines_uiom.pdf.
Hardell L., van Bavel B., Lindström G., Fredriksson M., Hagberg H., Liljegren G., et al. Higher concentrations of specific polychlorinated biphenyl congeners in adipose tissue from non-Hodgkin's lymphoma patients compared with controls without a malignant disease. Int J Oncol 1996, 9:603-608.
Hardell K., Carlberg M., Hardell L., Björnfoth H., Ericson Jogsten I., Eriksson M., et al. Concentrations of organohalogen compounds and titres of antibodies to Epstein-Barr virus antigens and the risk for non-Hodgkin lymphoma. Oncol Rep 2009, 21:1567-1576.
Hardell L., Eriksson M. Is the decline of the increasing incidence of non-Hodgkin lymphoma in Sweden and other countries a result of cancer preventive measures?. Environ Health Perspect 2003, 111:1704-1706.
Hardell L., Eriksson M., Lindström G., van Bavel B., Linde A., Carlberg M., et al. Case control study on concentrations of organohalogen compounds and titers of antibodies to Epstein-Barr virus antigens in the etiology of non-Hodgkin lymphoma. Leuk Lymphoma 2001, 42:619-629.
Hooiveld M., Heederik D.J., Kogevinas M., Boffetta P., Needham L.L., Patterson D.G., et al. Second follow-up of a Dutch cohort occupationally exposed to phenoxy herbicides, chlorophenols, and contaminants. Am J Epidemiol 1998, 147:891-901.
Kogevinas M., Becher H., Benn T., Bertazzi P.A., Boffetta P., Bueno-de-Mesquita H.B., et al. Cancer mortality in workers exposed to chlorophenoxy herbicides, chlorophenols and dioxins: An expanded and updated international cohort study. Am J Epidemiol 1997, 145:1061-1075.
Rothman N., Cantor K.P., Blair A., Bush D., Brock J.W., Helzlsouer K., et al. A nested case control study of non-Hodgkin lymphoma and serum organochlorine residues. Lancet 1997, 350:240-244.
Safe S. Toxicology, structure-function relationship, and human and environmental health impacts of polychlorinated biphenyls: Progress and problems. Environ Health Perspect 1993, 100:259-268.
Schisterman E.F., Whitcomb B.W., Louis G.M., Louis T.A. Lipid adjustment in the analysis of environmental contaminants and human health risks. Environ Health Perspect 2005, 113:853-857.
Schroeder J.C., Olshan A.F., Baric R., Dent G.A., Weinberg C.R., Yount B., et al. Agricultural risk factors for t(14;18) subtypes of non-Hodgkin's lymphoma. Epidemiology 2001, 12:701-709.
Spinelli J.J., Ng C.H., Weber J.P. Organochlorines and risk of non-Hodgkin lymphoma. Int J Cancer 2007, 121:2767-2775.
Viel J.F., Arveux P., Baverel J., Cahn J.Y. Soft-tissue sarcoma and non-Hodgkin's lymphoma clusters around a municipal solid waste incinerator with high dioxin emission levels. Am J Epidemiol 2000, 152:13-19.
Viel J.F., Daniau C., Goria S., Fabre P., de Crouy-Chanel P., Sauleau E.A., et al. Risk for non Hodgkin's lymphoma in the vicinity of French municipal solid waste incinerators. Environ Health 2008, 7:51.
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