Poster (Scientific congresses and symposiums)
Disseminated Penicillium marneffei infection contrated in China
Hayette, Marie-Pierre; Mukeba Tschialala, Didier; Meex, Cécile et al.
20072nd Pan african medical mycology conference PAMMS


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Keywords :
Penicillium marneffei; China; disseminated infection
Abstract :
[en] Penicillium marneffei infection is a rare fungal disease that cause significant disease in immunosuppressed patients. The geographical distribution of this dimorphic fungus is restricted to Asia, Southeast and Far East, where the disease is considered as an indicator of acquired immunodeficiency syndrome (AIDS). Case report. A 42-year old Congolese woman living in Lubumbashi was admitted at the university hospital of Liège for exploration of a general status impairment. She experienced for three months spiking fever, weight loss, productive cough with bloody expectorations and progressive dyspnoea. She reported also to have non-bloody mild diarrhoea with abdominal pain. The HIV antibody status was positive with a low CD4 T lymphocytes count (28/µl). Pulmonary infiltrates were visualized on chest radiography and the computed tomography revealed the presence of a severe pneumopathy characterised by bilateral micronodular lesions. Mediastinal polyadenopathies associated with hepato- and splenomegaly were also highlighted. Bronchoscopy was performed and bronchial aspirations revealed the presence of numerous leucocytes with the presence of intracellular Gram positive organisms suggestive of yeasts. Ziehl, Giemsa and Gomori-Grocott staining were also performed. Ziehl staining was negative. The morphological aspect given by Giemsa staining excluded infection and the PCR specific for T. gondii B1 gene was negative. However, Gomori-Grocott staining revealed the presence of intracellular oval, elongated, sausage-shaped cells with a single transverse septum (3 to 5 µm). Penicillium marneffei was isolated from blood culture and respiratory samples. Intraveinous amphotericin B treatment was administrated during 15 days followed by itraconazole oral administration (200 mg/j). The antimycotic treatment improved the patient condition and despite other clinical troubles she was prematurely discharged because of financial problems. Conclusion. Opportunistic agents involved in HIV-infected patients differ in Africa and Asia and it is important to be able to make a rapid diagnosis with the aid of an experienced laboratory.
Disciplines :
Immunology & infectious disease
Author, co-author :
Hayette, Marie-Pierre ;  Université de Liège - ULiège > Microbiologie médicale
Mukeba Tschialala, Didier;  Centre Hospitalier Universitaire de Liège - CHU > Maladies infectieuses et médecine interne générale
Meex, Cécile ;  Université de Liège - ULiège > Microbiologie médicale
Frippiat, Frédéric  ;  Université de Liège - ULiège > Maladies infectieuses et médecine interne générale - Direction médicale
Leonard, Philippe ;  Université de Liège - ULiège > Maladies infectieuses et médecine interne générale
Huynen, Pascale ;  Université de Liège - ULiège > Microbiologie médicale
Melin, Pierrette  ;  Université de Liège - ULiège > Microbiologie médicale
De Mol, Patrick ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale
Language :
Title :
Disseminated Penicillium marneffei infection contrated in China
Publication date :
Number of pages :
1,2 X 1
Event name :
2nd Pan african medical mycology conference PAMMS
Event organizer :
Dr. Hester Vismer, Medical research council (PROMEC Unit)
Event place :
Cape Town, South Africa, South Africa
Event date :
6-8 may 2007
Audience :
Available on ORBi :
since 11 January 2011


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