[en] Self-assembly of nonionic amphiphilic poly(ethylene oxide)-b-poly(ε-caprolactone) (PEO-b-PCL) and poly(ethylene oxide)-b-poly(γ-methyl-ε-caprolactone) (PEO-b-PMCL) has been studied in water by dynamic light scattering (DLS). The aqueous solutions have been prepared by three methods, i.e., dialysis of solutions in a common organic solvent against water, rapid addition of water to organic solutions, and rapid addition of organic solutions into water. Several common organic solvents have been used: tetrahydrofuran (THF), dimethylformamide (DMF), dimethylacetamide (DMAc) and dimethylsulfoxide (DMSO). The dialysis method is not reproducible and leads to very large and polydispersed particles (~1µm). In contrast, nanoparticles are formed by the two other methods with a low polydispersity and a size in the 30-10 nm range, depending on the organic solvent used. The particle size increases when the concentration in the organic solvent is decreased. The effect of temperature and length of the hydrophobic block has also been studied.
Research Center/Unit :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Chemistry Materials science & engineering
Author, co-author :
Vangeyte, Patrick; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Gautier, Sandrine; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Jérôme, Robert ; Center for Education and Research on Macromolecules (CERM) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Language :
English
Title :
About the methods of preparation of poly(ethylene oxide)-b-poly(epsilon-caprolactone) nanoparticles in water. Analysis by dynamic light scattering
Publication date :
02 August 2004
Journal title :
Colloids and Surfaces A: Physicochemical and Engineering Aspects
BELSPO - SPP Politique scientifique - Service Public Fédéral de Programmation Politique scientifique FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture
Commentary :
The authors acknowledge Colloids and Surfaces A : Physicochemical and Engineering Aspects (Elsevier) for allowing them to archive this paper.
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